Title
Functional CpG methylation system in a social insect
UMMS Affiliation
Department of Cell and Developmental Biology
Publication Date
10-28-2006
Document Type
Article
Subjects
Amino Acid Sequence; Animals; Base Composition; Bees; Computational Biology; DNA; DNA (Cytosine-5-)-Methyltransferase; *DNA Methylation; DNA-Binding Proteins; Dinucleoside Phosphates; Genes, Insect; Genome, Insect; Insect Proteins; Molecular Sequence Data
Disciplines
Bioinformatics | Cell Biology | Developmental Biology | Molecular Biology | Molecular Genetics
Abstract
DNA methylation systems are well characterized in vertebrates, but methylation in Drosophila melanogaster and other invertebrates remains controversial. Using the recently sequenced honey bee genome, we present a bioinformatic, molecular, and biochemical characterization of a functional DNA methylation system in an insect. We report on catalytically active orthologs of the vertebrate DNA methyltransferases Dnmt1 and Dnmt3a and b, two isoforms that contain a methyl-DNA binding domain, genomic 5-methyl-deoxycytosine, and CpG-methylated genes. The honey bee provides an opportunity to study the roles of methylation in social contexts.
DOI of Published Version
10.1126/science.1135213
Source
Science. 2006 Oct 27;314(5799):645-7. Link to article on publisher's site
Journal/Book/Conference Title
Science (New York, N.Y.)
Related Resources
PubMed ID
17068262
Repository Citation
Wang, Ying; Jorda, Mireia; Jones, Peter L.; Maleszka, Ryszard; Ling, Xu; Robertson, Hugh M.; Mizzen, Craig A.; Peinado, Miguel A.; and Robinson, Gene E., "Functional CpG methylation system in a social insect" (2006). Peter Jones Lab Publications. 6.
https://escholarship.umassmed.edu/peterjones/6
Comments
At the time of publication, Peter Jones was not yet affiliated with the University of Massachusetts Medical School.