N-CoR-HDAC corepressor complexes: roles in transcriptional regulation by nuclear hormone receptors
Department of Cell and Developmental Biology
Medical Subject Headings
Animals; Chromatin; DNA-Binding Proteins; *Gene Expression Regulation; HeLa Cells; Histone Deacetylases; Humans; Nuclear Proteins; Nuclear Receptor Co-Repressor 1; Nuclear Receptor Co-Repressor 2; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; *Transcription, Genetic; Xenopus laevis
Cell Biology | Developmental Biology | Molecular Biology | Molecular Genetics
Many nuclear hormone receptors (NHRs) actively repress the expression of their primary response genes through the recruitment of transcriptional corepressor complexes to regulated promoters. N-CoR and the highly related SMRT were originally isolated and characterized by their ability to interact exclusivelywith the unliganded forms of NHRs and confer transcriptional repression. Recently, both the N-CoR and SMRT corepressors have been found to exist in vivo in multiple, distinct macromolecular complexes. While these corepressor complexes differ in overall composition, a general theme is that they contain histone deacetylase enzymatic activity. Several of these complexes contain additional transcriptional corepressor proteins with functional ties to chromatin structure. Together, these data suggest that modulation of chromatin structure plays a central role in N-CoR mediated transcriptional repression from unliganded NHRs.
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Citation: Curr Top Microbiol Immunol. 2003;274:237-68.
Jones, Peter L. and Shi, Y.-B., "N-CoR-HDAC corepressor complexes: roles in transcriptional regulation by nuclear hormone receptors" (2003). Peter Jones Lab Publications. 2.