Sweat testing infants detected by cystic fibrosis newborn screening
Department of Pediatrics; New England Newborn Screening Program
Age Factors; Algorithms; Chlorides; Cystic Fibrosis; DNA Mutational Analysis; Decision Trees; Early Diagnosis; False Negative Reactions; False Positive Reactions; Follow-Up Studies; Humans; Infant, Newborn; Iontophoresis; Linear Models; Massachusetts; Muscarinic Agonists; Neonatal Screening; Patient Selection; Pilocarpine; Reference Values; Referral and Consultation; Risk Factors; Sweat
Allergy and Immunology | Pediatrics | Respiratory Tract Diseases
OBJECTIVE: Describe and define limitations of early pilocarpine iontophoresis (sweat testing) for cystic fibrosis (CF) newborn screening (NBS).
STUDY DESIGN: Population-based results from follow-up of CF NBS-positive newborns.
RESULTS: Insufficient quantity of sweat is more likely if the sweat test is done too early, but testing is generally successful after 2 weeks of age. Sweat chloride levels drop over the first weeks of life. CF carriers have higher sweat chloride concentrations than non-carriers.
CONCLUSIONS: Sweat testing can be performed effectively after 2 weeks of age for CF NBS-positive newborns. Earlier testing has a higher risk of insufficient sweat for completing testing.
DOI of Published Version
J Pediatr. 2005 Sep;147(3 Suppl):S69-72. Link to article on publisher's site
The Journal of pediatrics
Parad RB, Comeau AM, Dorkin HL, Dovey M, Gerstle R, Martin T, O'Sullivan BP. (2005). Sweat testing infants detected by cystic fibrosis newborn screening. Pulmonary and Allergy. https://doi.org/10.1016/j.jpeds.2005.08.015. Retrieved from https://escholarship.umassmed.edu/peds_pulmonary/9