This collection showcases the journal articles and other publications authored by faculty and researchers in the Division of Pulmonary and Allergy in the Department of Pediatrics at the University of Massachusetts Medical School.

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Publications from 2018

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Editing out five Serpina1 paralogs to create a mouse model of genetic emphysema, Florie Borel, Huaming Sun, Marina Zieger, Andrew Cox, Brynn Cardozo, Weiying Li, Gabriella Oliveira, Airiel Davis, Alisha Gruntman, Terence R. Flotte, Michael H. Brodsky, Andrew M. Hoffman, Mai K. Elmallah, and Christian Mueller

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Recombinant Adeno-Associated Virus-Based Gene Therapy for Disorders Detected by Newborn Screening: Inherent Limitations of This Approach, Terence R. Flotte

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Severe Toxicity in Nonhuman Primates and Piglets with Systemic High-Dose Administration of Adeno-Associated Virus Serotype 9-Like Vectors: Putting Patients First, Terence R. Flotte and Hildegard Buning

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Aerobic Glycolysis Is Essential for Normal Rod Function and Controls Secondary Cone Death in Retinitis Pigmentosa, Lolita Petit, Shan Ma, Joris Cipi, Shun-Yun Cheng, Marina Zieger, Nissim Hay, and Claudio Punzo

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Aerobic Glycolysis Is Essential for Normal Rod Function and Controls Secondary Cone Death in Retinitis Pigmentosa, Lolita Petit, Shan Ma, Joris Cipi, Shun-Yun Cheng, Marina Zieger, Nissim Hay, and Claudio Punzo

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In vivo genome editing partially restores alpha1-antitrypsin in a murine model of AAT deficiency, Chun-Qing Song, Dan Wang, Tingting Jiang, Kevin O'Connor, Qiushi Tang, Lingling Cai, Xiangrui Li, Zhiping Weng, Hao Yin, Guangping Gao, Christian Mueller, Terence R. Flotte, and Wen Xue

Publications from 2017

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It is Time for Zero Tolerance for Sexual Harassment in Academic Medicine, Carol K. Bates, Reshma Jagsi, Lynn K. Gordon, Elizabeth Travis, Archana Chatterjee, Marin Gillis, Olivia Means, Linda Chaudron, Rebecca Ganetzky, Martha Gulati, Barbara Fivush, Poonam Sharma, Amelia Grover, Diana Lautenberger, and Terence R. Flotte

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Design, Cloning, and In Vitro Screening of Artificial miRNAs to Silence Alpha-1 Antitrypsin, Florie Borel and Christian Mueller

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Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of alpha-1 Antitrypsin Deficiency, Florie Borel, Qiushi Tang, Gwladys Gernoux, Cynthia Greer, Ziqiong Wang, Adi Barzel, Mark A. Kay, Leonard D. Shultz, Dale L. Greiner, Terence R. Flotte, Michael A. Brehm, and Christian Mueller

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Quantification of Z-AAT by a Z-Specific "Sandwich" ELISA, Florie Borel, Qiushi Tang, and Christian Mueller

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Class I-restricted T-cell responses to a polymorphic peptide in a gene therapy clinical trial for alpha-1-antitrypsin deficiency, Roberto Calcedo, Suryanarayan Somanathan, Qiuyue Qin, Michael R. Betts, Andrew J. Rech, Robert H. Vonderheide, Christian Mueller, Terence R. Flotte, and James M. Wilson

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Quantification of Murine AAT by Direct ELISA, Andrew Cox and Christian Mueller

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Gene Therapy with an Adeno-Associated Viral Vector Expressing Human Interleukin-2 Alters Immune System Homeostasis in Humanized Mice, Philip A. Durost, Ken-Edwin Aryee, Fatima Manzoor, Roland M. Tisch, Christian Mueller, Agata Jurczyk, Leonard D. Shultz, and Michael A. Brehm

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Pediatric Obstructive Sleep Apnea in High-Risk Populations: Clinical Implications, Mai K. Elmallah, Evan Bailey, Michelle Trivedi, Ted M. Kremer, and Lawrence M. Rhein

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A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD, Rustam Esanov, Gabriela Toro Cabrera, Nadja S. Andrade, Tania F. Gendron, Robert H. Brown Jr., Michael Benatar, Claes Wahlestedt, Christian Mueller, and Zane Zeier

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Adeno-Associated Virus-Human Bocavirus 1 Chimeric Vectors: Ferreting Out Their Role in Airway Gene Therapy, Terence R. Flotte

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Empty Adeno-Associated Virus Capsids: Contaminant or Natural Decoy, Terence R. Flotte

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European Society of Gene and Cell Therapy (ESGCT) at 25: A Gene Therapy Community at Its Prime and on the Move, Terence R. Flotte

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Gene Therapy for Alcoholism and Other Substance Use Disorders, Terence R. Flotte

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One More Controversy: Adeno-Associated Virus in Stem Cells, Terence R. Flotte

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Sleeping Beauty Awakens New Interest, Terence R. Flotte

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The Negative Effects of Immigration Restrictions on the Gene Therapy Community, Terence R. Flotte

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Therapeutic Advances in Germany and Beyond, Terence R. Flotte

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The Science Policy Implications of a Trump Presidency, Terence R. Flotte

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The Gene Therapy Resource Program: A Decade of Dedication to Translational Research by the National Heart, Lung, and Blood Institute, Terence R. Flotte, Eric Daniels, Janet Benson, Jenee M. Bevett-Rose, Kenneth Cornetta, Margaret Diggins, Julie Johnston, Susan Sepelak, Johannes C. M. van der Loo, James M. Wilson, and Cheryl L. McDonald

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Regulatory and Exhausted T Cell Responses to AAV Capsid, Gwladys Gernoux, James M. Wilson, and Christian Mueller

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Systemic gene delivery transduces the enteric nervous system of guinea pigs and cynomolgus macaques, S. E. Gombash, C. J. Cowley, J. A. Fitzgerald, C. A. Lepak, M. G. Neides, K. Hook, L. J. Todd, G-D Wang, Christian Mueller, B. K. Kaspar, E. C. Bielefeld, A. J. Fischer, J. D. Wood, and K. D. Foust

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Therapeutics: Gene Therapy for Alpha-1 Antitrypsin Deficiency, Alisha Gruntman and Terence R. Flotte

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Central Role of IL-23 and IL-17 Producing Eosinophils as Immunomodulatory Effector Cells in Acute Pulmonary Aspergillosis and Allergic Asthma, Evelyn V. Santos Guerra, Chrono K. Lee, Charles A. Specht, Bhawna Yadav, Haibin Huang, Ali Akalin, Jun R. Huh, Christian Mueller, and Stuart M. Levitz

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Pathophysiology of Alpha-1 Antitrypsin Lung Disease, Michael Kalfopoulos, Kaitlyn Wetmore, and Mai K. Elmallah

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Gene Therapy 2017: Progress and Future Directions, Allison M. Keeler, Mai K. Elmallah, and Terence R. Flotte

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Airway smooth muscle dysfunction in Pompe (Gaa-/-) mice, Allison M. Keeler, Donghai Lui, Marina Zieger, Lang Xiong, Jeffrey Salemi, Karl D. Bellve, Barry J. Byrne, David D. Fuller, Ronghua ZhuGe, and Mai K. Elmallah

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5 Year Expression and Neutrophil Defect Repair after Gene Therapy in Alpha-1 Antitrypsin Deficiency, Christian Mueller, Gwladys Gernoux, Alisha M. Gruntman, Florie Borel, Emer P. Reeves, Roberto Calcedo, Farshid N. Rouhani, Anthony Yachnis, Margaret Humphries, Martha Campbell-Thompson, Louis M. Messina, Jeffrey D. Chulay, Bruce Trapnell, James M. Wilson, Noel G. McElvaney, and Terence R. Flotte

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Safe and Efficient Silencing with a Pol II, but Not a Pol lII, Promoter Expressing an Artificial miRNA Targeting Human Huntingtin, Edith L. Pfister, Kathryn O. Chase, Huaming Sun, Lori A. Kennington, Faith Conroy, Emily S. Johnson, Rachael Miller, Florie Borel, Neil Aronin, and Christian Mueller

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Artificial miRNAs reduce human mutant Huntingtin throughout the striatum in a transgenic sheep model of Huntington's disease, Edith L. Pfister, Natalie Dinardo, Erica Mondo, Florie Borel, Faith Conroy, Gwladys Gernoux, Lori A. Kennington, Richard P. Moser, Miguel Sena-Esteves, Guangping Gao, Christian Mueller, and Neil Aronin

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Restrictive Lung Disease in the Cu/Zn Superoxide-Dismutase 1 G93A Amyotrophic Lateral Sclerosis Mouse Model, Lorelei Stoica, Allison M. Keeler, Lang Xiong, Michael Kalfopoulos, Kaitlyn Desrochers, Robert H. Brown Jr., Miguel Sena-Esteves, Terence R. Flotte, and Mai K. Elmallah

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Quantification of Total Human Alpha-1 Antitrypsin by Sandwich ELISA, Qiushi Tang, Alisha Gruntman, and Terence R. Flotte

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Pediatric Obstructive Sleep Apnea and Asthma: Clinical Implications, Michelle Trivedi, Mai K. Elmallah, Evan Bailey, Ted M. Kremer, and Lawrence M. Rhein

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School nurse asthma program reduces healthcare utilization in children with persistent asthma, Michelle Trivedi, Janki Patel, Darleen M. Lessard, Ted M. Kremer, Nancy Byatt, Wanda Phipatanakul, Lori Pbert, and Robert J. Goldberg

Publications from 2016

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Therapeutic rAAVrh10 Mediated SOD1 Silencing in Adult SOD1(G93A) Mice and Nonhuman Primates, Florie Borel, Gwladys Gernoux, Brynn Cardozo, Jake P. Metterville, Gabriela Toro Cabrera, Lina Song, Qin Su, Guang Ping Gao, Mai K. Elmallah, Robert H. Brown Jr., and Christian Mueller

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Self-Complementary Adeno-Associated Virus Vectors Improve Transduction Efficiency of Corneal Endothelial Cells, Anja K. Gruenert, Marta Czugala, Christian Mueller, Marco Schmeer, Martin Schleef, Friedrich E. Kruse, and Thomas A. Fuchsluger

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Does the Mutant CAG Expansion in Huntingtin mRNA Interfere with Exonucleolytic Cleavage of its First Exon, Wanzhao Liu, Edith L. Pfister, Lori A. Kennington, Kathryn O. Chase, Christian Mueller, Marian DiFiglia, and Neil Aronin

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Development of rAAV2-CFTR: History of the First rAAV Vector Product to be Used in Humans, Heather S. Loring, Mai K. Elmallah, and Terence R. Flotte

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Adeno-associated virus-delivered artificial microRNA extends survival and delays paralysis in an amyotrophic lateral sclerosis mouse model, Lorelei Stoica, Sophia H. Todeasa, Gabriela Toro Cabrera, Johnny Salameh, Mai K. Elmallah, Christian Mueller, Robert H. Brown Jr., and Miguel Sena-Esteves

Publications from 2015

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Targeted gene delivery to the enteric nervous system using AAV: a comparison across serotypes and capsid mutants, Matthew J. Benskey, Nathan C. Kuhn, James J. Galligan, Joanna Garcia, Shannon E. Boye, William W. Hauswirth, Christian Mueller, Sanford L. Boye, and Fredric P. Manfredsson

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Adeno-Associated Virus Type 2 and Hepatocellular Carcinoma, Kenneth I. Berns, Barry J. Byrne, Terence R. Flotte, Guang Ping Gao, William W. Hauswirth, Roland W. Herzog, Nicholas Muzyczka, Thierry VandenDriessche, Xiao Xiao, Sergei Zolotukhin, and Arun Srivastava

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Delivery of Adeno-Associated Virus Gene Therapy by Intravascular Limb Infusion Methods, Alisha Gruntman and Terence R. Flotte

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Progress with Recombinant Adeno-Associated Virus Vectors for Gene Therapy of Alpha-1 Antitrypsin Deficiency, Alisha Gruntman and Terence R. Flotte

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Stability and compatibility of recombinant adeno-associated virus under conditions commonly encountered in human gene therapy trials, Alisha Gruntman, Lin Su, Qin Su, Guangping Gao, Christian Mueller, and Terence R. Flotte

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Hereditary mucoepithelial dysplasia and severe respiratory distress, Mahmoud Halawa, Mutasim N. Abu-Hasan, and Mai K. Elmallah

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Efficient and Targeted Transduction of Nonhuman Primate Liver With Systemically Delivered Optimized AAV3B Vectors, Shaoyong Li, Li Zhong, Mengxin Li, Qin Su, Ran He, Qiushi Tang, Dale L. Greiner, Michael A. Brehm, Terence R. Flotte, Christian Mueller, and Guangping Gao

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Current status of gene therapy for alpha-1 antitrypsin deficiency, Heather S. Loring and Terence R. Flotte

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Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice, Owen M. Peters, Gabriela Toro Cabrera, Helene Tran, Jeanne E. McKeon, Jake P. Metterville, Alexandra Weiss, Nicholas Wightman, Johnny Salameh, Huaming Sun, Zachary Kennedy, Ziqiang Lin, Fen-Biao Gao, Peter Sapp, Daryl Bosco, Christian Mueller, and Robert H. Brown Jr.

Publications from 2013

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A single intravenous rAAV injection as late as P20 achieves efficacious and sustained CNS Gene therapy in canavan mice, Seemin Seher Ahmed, Huapeng Li, Chunyan Cao, Elif M. Sikoglu, Andrew R. Denninger, Qin Su, Samuel Eaton, Ana A. Liso Navarro, Jun Xie, Sylvia Szucs, Hongwei Zhang, Constance M. Moore, Daniel A. Kirschner, Thomas N. Seyfried, Terence R. Flotte, Reuben Matalon, and Guangping Gao

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Gene transfer in the liver using recombinant adeno-associated virus, Seemin Seher Ahmed, Jia Li, Jonathan G. Godwin, Guangping Gao, and Li Zhong

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Birth of a new therapeutic platform: 47 years of adeno-associated virus biology from virus discovery to licensed gene therapy, Terence R. Flotte

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Gene transfer in skeletal and cardiac muscle using recombinant adeno-associated virus, Alisha M. Gruntman, Lawrence T. Bish, Christian Mueller, H. Lee Sweeney, Terence R. Flotte, and Guangping Gao

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Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expression, Christian Mueller, Jeffrey D. Chulay, Bruce C. Trapnell, Margaret Humphries, Brenna Carey, Robert A. Sandhaus, Noel G. McElvaney, Louis M. Messina, Qiushi Tang, Farshid N. Rouhani, Martha Campbell-Thompson, Ann Dongtao Fu, Anthony Yachnis, David R. Knop, Guo-Jie Ye, Mark Brantly, Roberto Calcedo, Suryanarayan Somanathan, Lee P. Richman, Robert H. Vonderheide, Maigan A. Hulme, Todd M. Brusko, James M. Wilson, and Terence R. Flotte

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Gene-based therapy for alpha-1 antitrypsin deficiency, Christian Mueller and Terence R. Flotte

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Evolution of pancreatic function during the first year in infants with cystic fibrosis, Brian P. O'Sullivan, Dawn Baker, Katherine G. Leung, George W. Reed, Susan S. Baker, and Drucy Borowitz

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Infection control in cystic fibrosis: share and share alike, Brian P. O'Sullivan and Christopher M. Sassetti

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Translating the genomics revolution: the need for an international gene therapy consortium for monogenic diseases, Jacques P. Tremblay, Terence R. Flotte, and Guangping Gao

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Finding the striatum in sheep: use of a multi-modal guided approach for convection enhanced delivery, I. M. J. van der Bom, Richard P. Moser, Guangping Gao, Erica Mondo, Denice O'Connell, Matthew J. Gounis, Sarah McGowan, J. Chaurette, N. Bishop, Miguel Sena-Esteves, Christian Mueller, and Neil Aronin

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Recombinant adeno-associated virus integration sites in murine liver after ornithine transcarbamylase gene correction, Li Zhong, Nirav Malani, Mengxin Li, Troy Brady, Jun Xie, Peter Bell, Shaoyong Li, Haven Jones, James M. Wilson, Terence R. Flotte, Frederic D. Bushman, and Guangping Gao

Publications from 2012

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Induction of Group IVC Phospholipase A2 in Allergic Asthma: Transcriptional Regulation by TNF-α in Bronchoepithelial Cells, Justin S. Bickford, Kimberly J. Newsom, John-David Herlihy, Christian Mueller, Benjamin Keeler, Xiaolei Qiu, Jewell N. Walters, Nan Su, Shannon M. Wallet, Terence R. Flotte, and Harry S. Nick

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Gene transfer in the lung using recombinant adeno-associated virus, Alisha Gruntman, Christian Mueller, Terence R. Flotte, and Guangping Gao

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rAAV9 airway delivery results in effective knockdown of mutant alpha 1-antitrypsin in the liver while upregulating wildtype alpha 1-antitrypsin in the lung, Alisha Gruntman, Christian Mueller, Qiushi Tang, Lina Song, James M. Wilson, Terence R. Flotte, and Maria P. Limberis

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Long-term correction of very long-chain acyl-coA dehydrogenase deficiency in mice using AAV9 gene therapy, Allison M. Keeler, Thomas J. Conlon, Glenn Walter, Huadong Zeng, Scott A. Shaffer, Fu Dungtao, Kirsten E. Erger, Travis L. Cossette, Qiushi Tang, Christian Mueller, and Terence R. Flotte

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Cell and gene therapy for genetic diseases: inherited disorders affecting the lung and those mimicking sudden infant death syndrome, Allison M. Keeler and Terence R. Flotte

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Codon Optimization for Alpha 1-Antitrypsin Disease, Timothy Menz, Qiushi Tang, Lina Song, Christian Mueller, and Terence R. Flotte

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Sustained miRNA-mediated Knockdown of Mutant AAT With Simultaneous Augmentation of Wild-type AAT Has Minimal Effect on Global Liver miRNA Profiles, Christian Mueller, Qiushi Tang, Alisha Gruntman, Keith S. Blomenkamp, Jeffrey H. Teckman, Lina Song, Phillip D. Zamore, and Terence R. Flotte

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Production and discovery of novel recombinant adeno-associated viral vectors, Christian Mueller, Li Zhong, Dmitry Ratner, Miguel Sena-Esteves, and Guangping Gao

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A patient with asthma seeks medical advice, Brian P. O'Sullivan, Robert G. Zwerdling, and Ted M. Kremer

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A multi-center controlled trial of growth hormone treatment in children with cystic fibrosis, Michael S. Stalvey, Ran D. Anbar, Michael W. Konstan, Joan R. Jacobs, Bert Bakker, Barbara Lippe, and David E. Geller

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Long-term, efficient inhibition of microRNA function in mice using rAAV vectors, Jun Xie, Stefan L. Ameres, Randall H. Friedline, Jui-Hung Hung, Yu Zhang, Qing Xie, Li Zhong, Qin Su, Ran He, Mengxin Li, Huapeng Li, Xin Mu, Hongwei Zhang, Jennifer A. Broderick, Jason K. Kim, Zhiping Weng, Terence R. Flotte, Phillip D. Zamore, and Guangping Gao

Publications from 2011

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Preclinical evaluation of a recombinant adeno-associated virus vector expressing human alpha-1 antitrypsin made using a recombinant herpes simplex virus production method, Jeffrey D. Chulay, Guo-Jie Ye, Darby L. Thomas, David R. Knop, Janet M. Benson, Julie A. Hutt, Gensheng Wang, Margaret Humphries, and Terence R. Flotte

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The role of gene and cell therapy in the era of health care reform, Walter H. Ettinger and Terence R. Flotte

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Sendai virus vectors. Pushing the envelope in the lung, Terence R. Flotte

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Phase 2 clinical trial of a recombinant adeno-associated viral vector expressing α1-antitrypsin: interim results, Terence R. Flotte, Bruce C. Trapnell, Margaret Humphries, Brenna Carey, Roberto Calcedo, Farshid Rouhani, Martha Campbell-Thompson, Anthony T. Yachnis, Robert A. Sandhaus, Noel G. McElvaney, Christian Mueller, Louis M. Messina, James M. Wilson, Mark L. Brantly, David R. Knop, Guo-jie Ye, and Jeffrey D. Chulay

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No immune responses by the expression of the yeast Ndi1 protein in rats, Mathieu Marella, Byoung Boo Seo, Terence R. Flotte, Akemi Matsuno-Yagi, and Takao Yagi

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N-glycosylation augmentation of the cystic fibrosis epithelium improves Pseudomonas aeruginosa clearance, Ashley T. Martino, Christian Mueller, Sofia Braag, Pedro E. Cruz, Martha Campbell-Thompson, Shouguang Jin, and Terence R. Flotte

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Lack of cystic fibrosis transmembrane conductance regulator in CD3+ lymphocytes leads to aberrant cytokine secretion and hyperinflammatory adaptive immune responses, Christian Mueller, Sofia A. Braag, Allison M. Keeler, Craig Hodges, Mitchell Drumm, and Terence R. Flotte

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Hepatocyte-specific hypoxia-inducible factor-1alpha is a determinant of lipid accumulation and liver injury in alcohol-induced steatosis in mice, Bharath D. Nath, Ivan Levin, Timea Csak, Jan Petrasek, Christian Mueller, Karen Kodys, Donna Catalano, Pranoti Mandrekar, and Gyongyi Szabo

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Using hyperpolarized 3He MRI to evaluate treatment efficacy in cystic fibrosis patients, Yanping Sun, Brian P. O'Sullivan, John P. Roche, Ronn P. Walvick, Austin Reno, Dawn Baker, Joey Mansour, and Mitchell Albert

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MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression, Jun Xie, Qing Xie, Hongwei Zhang, Stefan L. Ameres, Jui-Hung Hung, Qin Su, Ran He, Xin Mu, Seemin Seher Ahmed, Soyeon Park, Hiroki Kato, Chengjian Li, Christian Mueller, Craig C. Mello, Zhiping Weng, Terence R. Flotte, Phillip D. Zamore, and Guangping Gao

Publications from 2010

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IL-10 delivery by AAV5 vector attenuates inflammation in mice with Pseudomonas pneumonia, S. M. Buff, H. Yu, J. N. McCall, S. M. Caldwell, T. W. Ferkol, Terence R. Flotte, and I. L. Virella-Lowell

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Dual reporter comparative indexing of rAAV pseudotyped vectors in chimpanzee airway, Terence R. Flotte, Anne C. Fischer, Jason Goetzmann, Christian Mueller, Liudmila Cebotaru, Ziying Yan, Lilli Wang, James M. Wilson, William B. Guggino, and John F. Engelhardt

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Cystic fibrosis newborn screening: using experience to optimize the screening algorithm, Jaime E. Hale, Richard B. Parad, Henry L. Dorkin, Robert Gerstle, Allen Lapey, Brian P. O'Sullivan, L. Terry Spencer, William Yee, and Anne Marie Comeau

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Characterization of a recombinant adeno-associated virus type 2 Reference Standard Material, Martin Lock, Susan McGorray, Alberto Auricchio, Eduard Ayuso, E. Jeffrey Beecham, Veronique Blouin-Tavel, Fatima Bosch, Mahuya Bose, Barry J. Bryne, Tina Caton, John A. Chiorini, Abdelwahed Chtarto, K. Reed Clark, Thomas Conlon, Christophe Darmon, Monica Doria, Anne Douar, Terence R. Flotte, Joyce D. Francis, Achille Francois, Mauro Giacca, Michael T. Korn, Irina Korytov, Xavier Leon, Barbara Leuchs, Gabriele Lux, Catherine Melas, Hiroaki Mizukami, Philippe Moullier, Marcus Muller, Keiya Ozawa, Tina Philipsberg, Karine Poulard, Christina Raupp, Christel Riviere, Sigrid D. Roosendaal, Richard Jude Samulski, Steven M. Soltys, Richard Surosky, Liliane Tenenbaum, Darby L. Thomas, Bart van Montfort, Gabor Veres, J. Fraser Wright, Yili Xu, Olga Zelenaia, Lorena Zentilin, and Richard O. Snyder

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Autoimmunity in a genetic disease-a cautionary tale, Melissa J. Moore and Terence R. Flotte

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Modulation of Exaggerated-IgE Allergic Responses by Gene Transfer-mediated Antagonism of IL-13 and IL-17e., Christian Mueller, Allison M. Keeler, Sofia Braag, Timothy Menz, Qiushi Tang, and Terence R. Flotte

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In vitro and in vivo functional characterization of gutless recombinant SV40-derived CFTR vectors, Christian Mueller, M. S. Strayer, Jeffrey Sirninger, Sofia A. Braag, Francisco Branco, Jean-Pierre Louboutin, Terence R. Flotte, and David S. Strayer

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Cystic Fibrosis: Diagnosis, Sweat Testing, and Newborn Screening, Brian P. O'Sullivan

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Inhaled aztreonam, Brian P. O'Sullivan, Uma Yasothan, and Peter Kirkpatrick

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Cystic Fibrosis, Michael S. Stalvey, Christian Mueller, and Terence R. Flotte

Publications from 2009

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Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy, Mark L. Brantly, Jeffrey D. Chulay, Lili Wang, Christian Mueller, Margaret Humphries, L. Terry Spencer, Farshid Rouhani, Thomas J. Conlon, Roberto Calcedo, Michael R. Betts, Carolyn Spencer, Barry J. Bryne, James M. Wilson, and Terence R. Flotte

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Oropharyngeal flora in healthy infants: observations and implications for cystic fibrosis care, David Carlson, Elizabeth McKeen, Michael Mitchell, Brenda B. Torres, Richard B. Parad, Anne Marie Comeau, and Brian P. O'Sullivan

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Cystic fibrosis pulmonary guidelines: airway clearance therapies, Patrick A. Flume, Karen A. Robinson, Brian P. O'Sullivan, Jonathan D. Finder, Robert L. Vender, Donna-Beth Willey-Courand, Terry B. White, and Bruce C. Marshall

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Recombinant AAV serotype and capsid mutant comparison for pulmonary gene transfer of alpha-1-antitrypsin using invasive and noninvasive delivery, Rejean Liqun Wang, Thomas J. McLaughlin, Travis Cossette, Qiushi Tang, Kevin Foust, Martha Campbell-Thompson, Ashley Martino, Pedro Cruz, Scott A. Loiler, Christian Mueller, and Terence R. Flotte

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Recombinant AAV Serotype and Capsid Mutant Comparison for Pulmonary Gene Transfer of alpha-1-Antitrypsin Using Invasive and Noninvasive Delivery, Rejean Liqun Wang, Thomas J. McLaughlin, Travis Cossette, Qiushi Tang, Kevin Foust, Martha Campbell-Thompson, Ashley Martino, Pedro Cruz, Scott Loiler, Christian Mueller, and Terence R. Flotte