The faculty members of the Department of Pediatrics at the University of Massachusetts Medical School teach medical students, interns and residents, and they conduct research in many topics related to child health such as HIV, leukemia, diabetes, cystic fibrosis, teen pregnancy, infant mortality, and health care delivery in the community. The University of Massachusetts Medical School is one of about 40 centers for the National Children’s Study (NCS), a federally funded longitudinal study to investigate the effects of the environment on the growth and development and health of children by following 100,000 children from pre-birth to age 21 years. Approximately 1000 of those children will be identified from Worcester County residents in Massachusetts. UMass is the only institution in Massachusetts to be identified as an NCS Center. This collection showcases the journal articles and other publications authored by faculty and researchers in the Department of Pediatrics.

To view this collection broken out by Department of Pediatrics divisions, visit Pediatric Divisions.

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Publications from 1994

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The activation-induced decrease in the platelet surface expression of the glycoprotein Ib-IX complex is reversible, Alan D. Michelson, Stephen E. Benoit, Michael H. Kroll, Jian-ming Li, Michael J. Rohrer, Anita S. Kestin, and Marc R. Barnard

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Chronic granulomatous disease and glutathione peroxidase deficiency, revisited, Peter E. Newburger, Stephen E. Malawista, Mary C. Dinauer, Terri Gelbart, Richard C. Woodman, Sunil Chada, Qichang Shen, Gretchen van Blaricom, Paul G. Quie, and John T. Curnutte

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Mutations in the promoter region of the gene for gp91-phox in X-linked chronic granulomatous disease with decreased expression of cytochrome b558, Peter E. Newburger, David G. Skalnik, Penelope J. Hopkins, Elizabeth A. Eklund, and John T. Curnutte

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Correlation of cognitive test scores and adequacy of treatment in adolescents with congenital hypothyroidism., New England Congenital Hypothyroidism Collaborative and Mary M. Lee (The Journal of pediatrics)

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Regulation of the human cellular glutathione peroxidase gene during in vitro myeloid and monocytic differentiation, Qichang Shen, Sunil Chada, Constance Whitney, and Peter E. Newburger

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Localization of HIV RNA in mitochondria of infected cells: potential role in cytopathogenicity, Mohan Somasundaran, Maria L. Zapp, Lars K. Beattie, Lizhen Pang, Kevin S. Byron, Gary J. Bassell, John L. Sullivan, and Robert H. Singer

Publications from 1993

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Detection of thyrotropin binding inhibitory activity in neonatal blood spots, Rosalind S. Brown, Ronald L. Bellisario, Elizabeth Mitchell, Paula Keating, and Diego Botero

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Pharmacokinetics of nevirapine: initial single-rising-dose study in humans, Sarah H. Cheeseman, Susan E. Hattox, Margaret M. McLaughlin, Richard A. Koup, Charla A. Andrews, Carol A. Bova, Joseph W. Pav, Tapon Roy, John L. Sullivan, and James J. Keirns

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Confidentiality in health care. A survey of knowledge, perceptions, and attitudes among high school students, Tina L. Cheng, Judith A. Savageau, Ann L. Sattler, and Thomas G. DeWitt

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Mullerian inhibiting substance in the diagnosis and management of intersex and gonadal abnormalities, Michael L. Gustafson, Mary M. Lee, Lara Asmundson, David T. MacLaughlin, and Patricia K. Donahoe (Journal of pediatric surgery)

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Human peripheral blood xenografts in the SCID mouse: characterization of immunologic reconstitution, RuthAnn M. Hesselton, Richard A. Koup, Mary A. Cromwell, Barney S. Graham, Michael Johns, and John L. Sullivan

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Prevalence of urinary tract infection in febrile infants, Alejandro Hoberman, Han-Pu Chao, David M. Keller, Robert Hickey, Holly W. Davis, and Demetrius Ellis

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Mullerian inhibiting substance: a gonadal hormone with multiple functions, Mary M. Lee and Patricia K. Donahoe (Endocrine reviews)

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Mullerian inhibiting substance is present in embryonic testes of dogs with persistent mullerian duct syndrome, Vicki N. Meyers-Wallen, Mary M. Lee, T. F. Manganaro, T. Kuroda, David T. MacLaughlin, and Patricia K. Donahoe (Biology of reproduction)

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Sequences in the 3'-untranslated region of the human cellular glutathione peroxidase gene are necessary and sufficient for selenocysteine incorporation at the UGA codon, Qichang Shen, Fong-Fong Chu, and Peter E. Newburger

Publications from 1992

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Silent human immunodeficiency virus type 1 infection: a rare occurrence in a high-risk heterosexual population, Doreen B. Brettler, Mohan Somasundaran, A. F. Forsberg, E. Krause, and John L. Sullivan

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Mullerian inhibiting substance as a marker for ovarian sex-cord tumor, Michael L. Gustafson, Mary M. Lee, Robert E. Scully, Ashby C. Moncure, Toshio Hirakawa, Annekathryn Goodman, Howard G. Muntz, Patricia K. Donahoe, David T. MacLaughlin, and Arlan F. Fuller Jr. (The New England journal of medicine)

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Isolation of the rat gene for Mullerian inhibiting substance, Christopher M. Haqq, Mary M. Lee, Richard Tizard, Mark Wysk, Janice DeMarinis, Patricia K. Donahoe, and Richard L. Cate (Genomics)

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Augmented growth hormone (GH) secretory burst frequency and amplitude mediate enhanced GH secretion during a two-day fast in normal men, Mark L. Hartman, Johannes D. Veldhuis, Michael L. Johnson, Mary M. Lee, K. G. M. M. Alberti, Eugene Samojlik, and Michael O. Thorner (The Journal of clinical endocrinology and metabolism)

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Mullerian inhibiting substance messenger ribonucleic acid expression in granulosa and Sertoli cells coincides with their mitotic activity, Seiichi Hirobe, Wei Wu He, Mary M. Lee, and Patricia K. Donahoe (Endocrinology)

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Developmentally regulated polyadenylation of two discrete messenger ribonucleic acids for mullerian inhibiting substance, Mary M. Lee, Richard L. Cate, Patricia K. Donahoe, and Gerald L. Waneck (Endocrinology)

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Human immunodeficiency virus type 1-infected HL-60 cells are capable of both monocytic and granulocytic differentiation, Cynthia A. Pise, Peter E. Newburger, and Christie A. Holland

Publications from 1991

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Clinical management of intersex abnormalities, Patricia K. Donahoe, David M. Powell, and Mary M. Lee (Current problems in surgery)

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Limiting dilution analysis of cytotoxic T lymphocytes to human immunodeficiency virus gag antigens in infected persons: in vitro quantitation of effector cell populations with p17 and p24 specificities, Richard A. Koup, Cheryl A. Pikora, Katherine Luzuriaga, Doreen B. Brettler, Eric S. Day, Gail Mazzara, and John L. Sullivan

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Broadly reactive antibody-dependent cellular cytotoxic response to HIV-1 envelope glycoproteins precedes broad neutralizing response in human infection, Richard A. Koup, Cheryl A. Pikora, Gail Mazzara, Dennis Panicali, and John L. Sullivan

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Antibody-dependent cell-mediated cytotoxicity directed by a human monoclonal antibody reactive with gp120 of HIV-1, Richard A. Koup, James E. Robinson, Quoc V. Nguyen, Cheryl A. Pikora, Bruce Blais, Allysen Roskey, Dennis Panicali, and John L. Sullivan

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Mullerian inhibiting substance production and cleavage is modulated by gonadotropins and steroids, Tatsuo Kuroda, Mary M. Lee, Richard C. Ragin, Seiichi Hirobe, and Patricia K. Donahoe (Endocrinology)

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Deficient human immunodeficiency virus type 1-specific cytotoxic T cell responses in vertically infected children, Katherine Luzuriaga, Richard A. Koup, Cheryl A. Pikora, Doreen B. Brettler, and John L. Sullivan

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Downregulation of the platelet surface glycoprotein Ib-IX complex in whole blood stimulated by thrombin, adenosine diphosphate, or an in vivo wound, Alan D. Michelson, Patricia A. Ellis, Marc R. Barnard, Goran B. Matic, Andrew F. Viles, and Anita S. Kestin

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In vitro regulation of human phagocyte cytochrome b heavy and light chain gene expression by bacterial lipopolysaccharide and recombinant human cytokines, Peter E. Newburger, Qun Dai, and Constance Whitney

Publications from 1990

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Deletions in the cytoplasmic domain of the polymeric immunoglobulin receptor differentially affect endocytotic rate and postendocytotic traffic, Philip P. Breitfeld, James E. Casanova, Wendy C. McKinnon, and Keith E. Mostov

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Effect of nocodazole on vesicular traffic to the apical and basolateral surfaces of polarized MDCK cells, Philip P. Breitfeld, Wendy C. McKinnon, and Keith E. Mostov

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Isolation and chromosomal localization of the human glutathione peroxidase gene, Sunil Chada, Michelle M. Le Beau, Linda Casey, and Peter E. Newburger

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Effect of E. coli endotoxin on mammalian cell growth and recombinant protein production, J. Epstein, Mary M. Lee, C. E. Kelly, and Patricia K. Donahoe (In vitro cellular and developmental biology : journal of the Tissue Culture Association)

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Mullerian inhibiting substance ontogeny and its modulation by follicle-stimulating hormone in the rat testes, Tatsuo Kuroda, Mary M. Lee, Christopher M. Haqq, David M. Powell, Thomas F. Manganaro, and Patricia K. Donahoe (Endocrinology)

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Subcellular localization of low-abundance human immunodeficiency virus nucleic acid sequences visualized by fluorescence in situ hybridization, Jeanne B. Lawrence, Lisa M. Marselle, Kevin S. Byron, Carol V. Johnson, John L. Sullivan, and Robert H. Singer

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Plasmin-induced redistribution of platelet glycoprotein Ib, Alan D. Michelson and Marc R. Barnard

Publications from 1989

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Alterations in the pulsatile mode of growth hormone release in men and women with insulin-dependent diabetes mellitus, Christopher M. Asplin, Amilton C. S. Faria, Elizabeth C. Carlsen, Veronica A. Vaccaro, Richard E. Barr, Ali Iranmanesh, Mary M. Lee, Johannes D. Veldhuis, and William S. Evans (The Journal of clinical endocrinology and metabolism)

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Factor VIII:C concentrate purified from plasma using monoclonal antibodies: human studies, Doreen B. Brettler, Ann D. Forsberg, Peter H. Levine, J. Petillo, K. Lamon, and John L. Sullivan

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Post-transcriptional regulation of glutathione peroxidase gene expression by selenium in the HL-60 human myeloid cell line, Sunil Chada, Constance Whitney, and Peter E. Newburger

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Differentiation of human hematopoietic cells increases expression of a gene transferred by a retroviral vector, Christie A. Holland, Sunil Chada, Jocyndra A. Wright, Constance Whitney, Kenichi Harigaya, Joel S. Greenberger, and Peter E. Newburger

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Detection of major histocompatibility complex class I-restricted, HIV-specific cytotoxic T lymphocytes in the blood of infected hemophiliacs, Richard A. Koup, John L. Sullivan, Peter H. Levine, Doreen B. Brettler, Anna Mahr, Gail Mazzara, Sara McKenzie, and Dennis Panicali

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Antigenic specificity of antibody-dependent cell-mediated cytotoxicity directed against human immunodeficiency virus in antibody-positive sera, Richard A. Koup, John L. Sullivan, Peter H. Levine, Frank E. Brewster, Anna Mahr, Gail Mazzara, Sara McKenzie, and Dennis Panicali

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Serum adrenal steroid concentrations in premature infants, Mary M. Lee, Lakshmy Rajagopalan, Gregory J. Berg, and Thomas Moshang Jr. (The Journal of clinical endocrinology and metabolism)

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Arrangement of repetitive sequences in the genome of herpesvirus Sylvilagus, Maria M. Medveczky, Peter Geck, Chester H. Clarke, Julie Byrnes, John L. Sullivan, and Peter G. Medveczky

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Time course of intracellular associations, processing, and cleavages of Ii forms and class II major histocompatibility complex molecules, Quoc V. Nguyen and Robert E. Humphreys

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Detection of HIV-1-infected cells from patients using nonisotopic in situ hybridization, Robert H. Singer, Kevin S. Byron, Jeanne B. Lawrence, and John L. Sullivan

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Time-dependent cleavage of a high-mannose form of Ii to p25 in an intracellular compartment, Lawrence James Thomas, Robert E. Humphreys, Walter Knapp, and Quoc V. Nguyen

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Soluble CD8 during T cell activation, Blake E. Tomkinson, Michael C. Brown, Stephen H. Ip, Susan Carrabis, and John L. Sullivan

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Characterization of the T cell-mediated cellular cytotoxicity during acute infectious mononucleosis, Blake E. Tomkinson, Richard T. Maziarz, and John L. Sullivan

Publications from 1988

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Expression of the X-CGD gene during induced differentiation of myeloid leukemia cell line HL-60, Kathleen A. Barker, Stuart H. Orkin, and Peter E. Newburger

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Pathogenesis of Herpesvirus sylvilagus infection in cottontail rabbits, RuthAnn M. Hesselton, Wen C. Yang, Peter G. Medveczky, and John L. Sullivan

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Platelet storage results in a redistribution of glycoprotein Ib molecules. Evidence for a large intraplatelet pool of glycoprotein Ib, Alan D. Michelson, Burt Adelman, Marc R. Barnard, Eddie Carroll, and Robert I. Handin

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Late effects: disorders of growth and sexual maturation associated with the treatment of childhood cancer, Thomas Moshang Jr. and Mary M. Lee (Journal of the Association of Pediatric Oncology Nurses)

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Induction of phagocyte cytochrome b heavy chain gene expression by interferon gamma, Peter E. Newburger, R. Alan B. Ezekowitz, Constance Whitney, Jocyndra A. Wright, and Stuart H. Orkin

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XK aprosencephaly and anencephaly in sibs, Phillip L. Townes, Karen L. Reuter, E. E. Rosquete, and B. Dale Magee

Publications from 1987

Hyperexpressed hairy leukemic cell Ii might bind to the antigen-presenting site of class II MHC molecules, William L. Elliot, Shan Lu, Que Nguyen, Patricia S. Reisert, Takeshi Sairenji, Christopher H. Sorli, Christopher J. Stille, Lawrence James Thomas, and Robert E. Humphreys

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Thrombin-induced changes in platelet membrane glycoproteins Ib, IX, and IIb-IIIa complex, Alan D. Michelson and Marc R. Barnard

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Hydrophobic strip-of-helix algorithm for selection of T cell-presented peptides, Christopher J. Stille, Lawrence James Thomas, Victor E. Reyes, and Robert E. Humphreys

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Activated lymphocytes during acute Epstein-Barr virus infection, Blake E. Tomkinson, David K. Wagner, David L. Nelson, and John L. Sullivan

Publications from 1985

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Campylobacter meningitis in childhood, Mary M. Lee, Robert C. Welliver, and Leonard J. La Scolea Jr. (Pediatric infectious disease)

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Status epilepticus and Epstein-Barr virus encephalopathy. Diagnosis by modern serologic techniques, James Russell, Marc Fisher, Justin A. Zivin, John L. Sullivan, and David A. Drachman

Publications from 1981

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Differences in synthesis of membrane proteins by leukemic cells from spleen and peripheral blood indicate distinct subsets of malignant cells in a patient with prolymphocytic leukemia, Robert Christopher Spiro, Jack E. Ansell, Isao Katayama, Kamala Muralidharan, John L. Sullivan, and Robert E. Humphreys

Publications from 1980

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Subsets of hairy cell leukemia defined by unique membrane proteins, Robert Christopher Spiro, Motohiko Aiba, Isao Katayama, Philip P. Raffa, Kiyoshi Sakamoto, David T. Purtilo, John L. Sullivan, and Robert E. Humphreys