Title

Delivery of Adeno-Associated Virus Gene Therapy by Intravascular Limb Infusion Methods

UMMS Affiliation

Department of Pediatrics, Division of Pulmonary and Allergy; Gene Therapy Center

Publication Date

2015-09-01

Document Type

Article

Disciplines

Genetics and Genomics | Therapeutics

Abstract

Recombinant adeno-associated virus (rAAV) can be delivered to the skeletal muscle of the limb (pelvic or thoracic) by means of regional intravascular delivery. This review summarizes the evolution of this technique to deliver rAAV either via the arterial blood supply or via the peripheral venous circulation. The focus of this review is on applications in large animal models, including preclinical studies. Based on this overview of past research, we aim to inform the design of preclinical and clinical studies.

DOI of Published Version

10.1089/humc.2015.116

Source

Hum Gene Ther Clin Dev. 2015 Sep;26(3):159-64. doi: 10.1089/humc.2015.116. Epub 2015 Sep 10. Link to article on publisher's site

Journal/Book/Conference Title

Human gene therapy. Clinical development

Related Resources

Link to Article in PubMed

PubMed ID

26357010

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