Dynamics of the resting CD4(+) T-cell latent HIV reservoir in infants initiating HAART less than 6 months of age
Authors
Persaud, DeborahPalumbo, Paul E.
Ziemniak, Carrie
Hughes, Michael D.
Alvero, Carmelita G.
Luzuriaga, Katherine
Yogev, Ram
Capparelli, Edmund V.
Chadwick, Ellen Gould
Document Type
Journal ArticlePublication Date
2012-07-31Keywords
Antiretroviral Therapy, Highly ActiveCD4-Positive T-Lymphocytes
Disease Reservoirs
Female
HIV Infections
HIV Protease Inhibitors
HIV-1
Humans
Infant
Lopinavir
Male
Ritonavir
Treatment Outcome
Viral Load
Virus Latency
Virus Replication
Immunology and Infectious Disease
Pediatrics
Virus Diseases
Metadata
Show full item recordAbstract
OBJECTIVES: Identification of HIV infection in exposed infants facilitates early therapy, which may limit viral reservoirs that maintain HIV infection under HAART. METHODS: The dynamics of the resting CD4 T-cell latent HIV reservoir was determined over the first 2 years of life in 17 HIV-infected infants initiating lopinavir/ritonavir-based HAART at a median age of 8.1 weeks and achieving adequate suppression of plasma viral load by 24 weeks. RESULTS: The resting CD4 T-cell latent HIV reservoir was detected in 12 of 14 (86%) infants tested at 24 weeks of HAART [median frequency 1.88 infectious units per million (IUPM); range <0.22 to 3.25) in six of 10 (60%) children retested at 96 weeks. The reservoir declined, from 24 to 96 weeks of HAART, at an estimated mean rate of 0.028 log10 IUPM/month, corresponding to a half-life of 11 months (95% confidence interval 6-30 months]. A strong relationship was found between the frequency of latently infected CD4 T cells at 96 weeks of HAART and time to first undetectable plasma viral load (Spearman r = 0.91, P < 0.001). CONCLUSION: Although the resting CD4 T-cell latent reservoir remains detectable over the first 2 years of HAART in a substantial proportion of infants, its size is associated with time to first undetectable viral load. To minimize HIV reservoirs in infants, rapid curtailment of viremia may limit HIV reservoirs and should be a therapeutic goal of early HAART in infants.Source
AIDS. 2012 Jul 31;26(12):1483-90. doi: 10.1097/QAD.0b013e3283553638.DOI
10.1097/QAD.0b013e3283553638Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43722PubMed ID
22555165Related Resources
Link to article in PubMedae974a485f413a2113503eed53cd6c53
10.1097/QAD.0b013e3283553638