MicroRNAs Absent in Caput Sperm Are Required for Normal Embryonic Development
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UMass Chan Affiliations
Department of Pediatrics, Division of Genes and DevelopmentDepartment of Biochemistry and Molecular Pharmacology
Document Type
Letter to the EditorPublication Date
2019-07-01Keywords
Cell BiologyCells
Developmental Biology
Embryonic Structures
Nucleic Acids, Nucleotides, and Nucleosides
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Zhou et al. (2019) report that embryos generated using sperm from the caput epididymis are fully capable of supporting full-term development, in contrast to our recent article (Conine et al., 2018). They also suggest that successful development of embryos generated using detergent-extracted sperm argues against the possibility that sperm delivers functional microRNAs (miRNAs) to the embryo. However, as several groups have demonstrated that sperm miRNAs are largely unaffected even by heavy detergent washes (Sharma et al., 2018,Yan et al., 2008), this experiment is not informative. We therefore focus on the primary finding of Zhou et al.: that embryos generated via intracytoplasmic sperm injection (ICSI) using caput epididymal sperm are viable and develop to term, which contrasts with Figures 3 and 7 of Conine et al., where we report that caput-derived embryos implant inefficiently and fail to develop further.Source
Dev Cell. 2019 Jul 1;50(1):7-8. doi: 10.1016/j.devcel.2019.06.007. Link to article on publisher's site
DOI
10.1016/j.devcel.2019.06.007Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43695PubMed ID
31265813Related Resources
ae974a485f413a2113503eed53cd6c53
10.1016/j.devcel.2019.06.007