Title

Recommendations on RBC Transfusions for Critically Ill Children With Nonhemorrhagic Shock From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative

UMMS Affiliation

Division of Pediatric Critical Care, Department of Pediatrics

Publication Date

2018-09-01

Document Type

Article

Disciplines

Critical Care | Health Services Administration | Hemic and Lymphatic Diseases | Pathological Conditions, Signs and Symptoms | Pediatrics | Therapeutics

Abstract

OBJECTIVES: To present the recommendations and supporting literature for RBC transfusions in critically ill children with nonhemorrhagic shock developed by the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.

DESIGN: Consensus conference series of international, multidisciplinary experts in RBC transfusion management of critically ill children.

METHODS: The panel of 38 experts developed evidence-based, and when evidence was lacking, expert-based clinical recommendations as well as research priorities for RBC transfusions in critically ill children. The nonhemorrhagic shock subgroup included five experts. Electronic searches were conducted using PubMed, EMBASE, and Cochrane Library databases from 1980 to May 2017. Agreement was obtained using the Research and Development/UCLA Appropriateness Method. Results were summarized using the Grading of Recommendations Assessment, Development, and Evaluation method.

RESULTS: Transfusion and Anemia Expertise Initiative Consensus Conference experts developed and voted on a total of four clinical and four research recommendations focused on RBC transfusion in the critically ill child with nonhemorrhagic shock. All recommendations reached agreement ( > 80%). Of the four clinical recommendations, three were based on consensus panel expertise, whereas one was based on weak pediatric evidence. In hemodynamically stabilized critically ill children with a diagnosis of severe sepsis or septic shock, we recommend not administering a RBC transfusion if the hemoglobin concentration is greater than or equal to 7 g/dL. Future studies are needed to determine optimum transfusion thresholds for critically ill children with nonhemorrhagic shock undergoing acute resuscitation.

CONCLUSIONS: The Transfusion and Anemia Expertise Initiative Consensus Conference developed pediatric-specific clinical and research recommendations regarding RBC transfusion in the critically ill child with nonhemorrhagic shock. Although agreement among experts was strong, available pediatric evidence was scant-revealing significant gaps in the existing literature.

Keywords

consensus conference, critically ill child, red blood cell, shock, transfusion

DOI of Published Version

10.1097/PCC.0000000000001620

Source

Pediatr Crit Care Med. 2018 Sep;19(9S Suppl 1):S121-S126. doi: 10.1097/PCC.0000000000001620. Link to article on publisher's site

Journal/Book/Conference Title

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Related Resources

Link to Article in PubMed

PubMed ID

30161066

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