Elevations in serum anti-flagellin and anti-LPS Igs are related to growth faltering in young Tanzanian children
Department of Pediatrics, Division of Gastroenterology and Nutrition
Biological Factors | Dietetics and Clinical Nutrition | Gastroenterology | Nutrition | Pediatrics
BACKGROUND: Antibodies to LPS and flagellin have been described as indirect measures of increased gastrointestinal permeability and may be markers of environmental enteric dysfunction (EED), which is a condition associated with poor child growth.
OBJECTIVE: We assessed whether LPS- and flagellin-specific immunoglobulin (Ig) concentrations were associated with poor growth in young Tanzanian children at risk of EED. DESIGN: Blood samples were obtained from 590 childre
RESULTS: Anti-LPS and anti-flagellin IgA and IgG concentrations increased over the first year of life and were higher than concentrations (measured at 9 mo of age) in healthy controls. Children with anti-flagellin IgA, anti-LPS IgA, anti-flagellin IgG, and anti-LPS IgG concentrations in the highest quartile at 6 wk of age were 2.02 (95% CI: 1.11, 3.67), 1.84 (95% CI: 1.03, 3.27), 1.94 (95% CI: 1.04, 3.62), and 2.31 (95% CI: 1.25, 4.27) times, respectively, more likely to become underweight (weight-for-age z score < -2) after adjustment for covariates (P-trend < 0.05) than were children with Ig concentrations in the lowest quartile. Children with increased concentrations of anti-flagellin IgA were also more likely to become wasted; however, there was no association between any of the markers and subsequent stunting.
CONCLUSION: Serologic measures of increased intestinal permeability to bacterial components are associated with subsequent poor growth and could help identify children who may benefit most from preventive interventions. This trial was registered at clinicaltrials.gov as NCT00421668.
anti-LPS antibodies, anti-flagellin antibodies, child growth, environmental enteric dysfunction, environmental enteropathy, intestinal biomarkers, intestinal permeability
DOI of Published Version
Am J Clin Nutr. 2016 Jun;103(6):1548-54. doi: 10.3945/ajcn.116.131409. Epub 2016 Apr 27. Link to article on publisher's site
The American journal of clinical nutrition
McDonald CM, Manji KP, Gosselin KB, Tran HQ, Liu E, Kisenge R, Aboud S, Fawzi WW, Gewirtz AT, Duggan CP. (2016). Elevations in serum anti-flagellin and anti-LPS Igs are related to growth faltering in young Tanzanian children. Pediatric Publications. https://doi.org/10.3945/ajcn.116.131409. Retrieved from https://escholarship.umassmed.edu/peds_pp/109