The platelet hyporeactivity of extremely low birth weight neonates is age-dependent
Department of Pediatrics
Adult; Age Factors; Blood Platelets; Factor V; Factor Va; Humans; Infant, Extremely Low Birth Weight; Infant, Newborn; P-Selectin; Platelet Glycoprotein GPIb-IX Complex
INTRODUCTION: We have previously demonstrated that, as compared to adults, the platelets of extremely low birth weight (ELBW) neonates are markedly hyporeactive on day 0-1 of life. The purpose of this study was to examine the age dependency of this hyporeactivity.
MATERIALS AND METHODS: On days 0-1, 3-4, and 10-14, peripheral blood was collected from 14 stable ELBW neonates and compared to peripheral blood from normal adults run in parallel. Whole blood flow cytometry was used to examine the activation-dependent increase in platelet surface P-selectin (reflecting degranulation) and platelet surface binding of factor V/Va (reflecting platelet surface procoagulant activity) and decrease in platelet surface glycoprotein (GP) Ib (the von Willebrand factor receptor).
RESULTS: In the physiologic milieu of whole blood, ELBW neonatal platelets on days 0-1 and 3-4 were markedly less reactive than adult platelets. However, by day 10-14, the platelet function of ELBW neonates improved significantly, although not completely to adult levels.
CONCLUSIONS: The age-dependent platelet hyporeactivity of ELBW neonates demonstrated in this study may be a contributing factor to the similar age-dependent propensity of ELBW neonates to intraventricular hemorrhage.
DOI of Published Version
Thromb Res. 2009 May;124(1):42-5. Epub 2008 Nov 20. Link to article on publisher's site
Bednarek, Francis J.; Bean, Stephen; Barnard, Marc R.; Frelinger, Andrew L. III; and Michelson, Alan D., "The platelet hyporeactivity of extremely low birth weight neonates is age-dependent" (2009). Neonatology. 12.