Interleukin-6 and interleukin-10 gene promoter polymorphisms and risk of endemic burkitt lymphoma
Department of Pediatrics; Department of Medicine, Division of Transfusion; Program in Bioinformatics and Integrative Biology
Bioinformatics | Cancer Biology | Computational Biology | Hemic and Lymphatic Diseases | Immunopathology | Neoplasms | Pediatrics | Virus Diseases
Overexpression of interleukin-6 (IL-6) and IL-10 in endemic Burkitt lymphoma (eBL) may facilitate tumorigenesis by providing a permissive cytokine milieu. Promoter polymorphisms influence interindividual differences in cytokine production. We hypothesized that children genetically predisposed for elevated cytokine levels may be more susceptible to eBL. Using case-control samples from western Kenya consisting of 117 eBL cases and 88 ethnically matched healthy controls, we tested for the association between eBL risk and IL-10 (rs1800896, rs1800871, and rs1800872) and IL-6 (rs1800795) promoter single nucleotide polymorphisms (SNPs) as well as IL-10 promoter haplotypes. In addition, the association between these variants and Epstein Barr Virus (EBV) load was examined. Results showed that selected IL-10 and IL-6 promoter SNPs and IL-10 promoter haplotypes were not associated with risk eBL or EBV levels in EBV-seropositive children. Findings from this study reveal that common variants within the IL-10 and IL-6 promoters do not independently increase eBL risk in this vulnerable population.
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Citation: Am J Trop Med Hyg. 2014 Sep 3;91(3):649-54. doi: 10.4269/ajtmh.13-0616. Epub 2014 Jul 28. Link to article on publisher's site
Oduor, Cliff I.; Chelimo, Kiprotich; Ouma, Collins; Mulama, David H.; Foley, Joslyn; Vulule, John M.; Bailey, Jeffrey A.; and Moormann, Ann M., "Interleukin-6 and interleukin-10 gene promoter polymorphisms and risk of endemic burkitt lymphoma" (2014). Immunology/Infectious Disease. 74.