Interleukin-6 and interleukin-10 gene promoter polymorphisms and risk of endemic burkitt lymphoma
Department of Pediatrics; Department of Medicine, Division of Transfusion; Program in Bioinformatics and Integrative Biology
Bioinformatics | Cancer Biology | Computational Biology | Hemic and Lymphatic Diseases | Immunopathology | Neoplasms | Pediatrics | Virus Diseases
Overexpression of interleukin-6 (IL-6) and IL-10 in endemic Burkitt lymphoma (eBL) may facilitate tumorigenesis by providing a permissive cytokine milieu. Promoter polymorphisms influence interindividual differences in cytokine production. We hypothesized that children genetically predisposed for elevated cytokine levels may be more susceptible to eBL. Using case-control samples from western Kenya consisting of 117 eBL cases and 88 ethnically matched healthy controls, we tested for the association between eBL risk and IL-10 (rs1800896, rs1800871, and rs1800872) and IL-6 (rs1800795) promoter single nucleotide polymorphisms (SNPs) as well as IL-10 promoter haplotypes. In addition, the association between these variants and Epstein Barr Virus (EBV) load was examined. Results showed that selected IL-10 and IL-6 promoter SNPs and IL-10 promoter haplotypes were not associated with risk eBL or EBV levels in EBV-seropositive children. Findings from this study reveal that common variants within the IL-10 and IL-6 promoters do not independently increase eBL risk in this vulnerable population.
DOI of Published Version
Am J Trop Med Hyg. 2014 Sep 3;91(3):649-54. doi: 10.4269/ajtmh.13-0616. Epub 2014 Jul 28. Link to article on publisher's site
The American journal of tropical medicine and hygiene
Oduor CI, Chelimo K, Ouma C, Mulama DH, Foley J, Vulule JM, Bailey JA, Moormann AM. (2014). Interleukin-6 and interleukin-10 gene promoter polymorphisms and risk of endemic burkitt lymphoma. Immunology/Infectious Disease. https://doi.org/10.4269/ajtmh.13-0616. Retrieved from https://escholarship.umassmed.edu/peds_immunology/74