Title

Efficacy model for antibody-mediated pre-erythrocytic malaria vaccines

UMMS Affiliation

Department of Pediatrics; Department of Quantitative Health Sciences

Publication Date

5-7-2011

Document Type

Article

Subjects

Adult; Antibodies, Protozoan; Antigens, Protozoan; Erythrocytes; Female; Humans; Immunoglobulin G; Kenya; Malaria Vaccines; Malaria, Falciparum; Male; *Models, Biological; Plasmodium falciparum; Protozoan Proteins; Sporozoites

Disciplines

Immunology and Infectious Disease | Pediatrics

Abstract

Antibodies to the pre-erythrocytic antigens, circumsporozoite protein (CSP), thrombospondin-related adhesive protein (TRAP) and liver-stage antigen 1, have been measured in field studies of semi-immune adults and shown to correlate with protection from Plasmodium falciparum infection. A mathematical model is formulated to estimate the probability of sporozoite infection as a function of antibody titres to multiple pre-erythrocytic antigens. The variation in antibody titres from field data was used to estimate the relationship between the probability of P. falciparum infection per infectious mosquito bite and antibody titre. Using this relationship, we predict the effect of vaccinations that boost baseline CSP or TRAP antibody titres. Assuming the estimated relationship applies to vaccine-induced antibody titres, then single-component CSP or TRAP antibody-mediated pre-erythrocytic vaccines are likely to provide partial protection from infection, with vaccine efficacy of approximately 50 per cent depending on the magnitude of the vaccine-induced boost to antibody titres. It is possible that the addition of a TRAP component to a CSP-based vaccine such as RTS,S would provide an increase in infection-blocking efficacy of approximately 25 per cent should the problem of immunological interference between antigens be overcome.

DOI of Published Version

10.1098/rspb.2010.1697

Source

Proc Biol Sci. 2011 May 7;278(1710):1298-305. Epub 2010 Oct 13. Link to article on publisher's site

Journal/Book/Conference Title

Proceedings. Biological sciences / The Royal Society

Related Resources

Link to Article in PubMed

PubMed ID

20943696

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