Infectious mononucleosis

UMMS Affiliation

Department of Pediatrics; Program in Molecular Medicine



Document Type


Medical Subject Headings

Adolescent; Adrenal Cortex Hormones; Antibodies, Viral; Antiviral Agents; Diagnosis, Differential; Female; *Herpesvirus 4, Human; Humans; *Infectious Mononucleosis; Male; Pharyngitis; Streptococcal Infections; Streptococcus pyogenes


Immunology and Infectious Disease | Pediatrics


This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the authors' clinical recommendations. The case: A 16-year-old, previously healthy girl presents with a several-day history of fever, sore throat, and malaise. She appears very tired and has a temperature of 39°C. A physical examination is remarkable for diffuse pharyngeal erythema with moderately enlarged tonsils and the presence of several enlarged, tender anterior and posterior cervical lymph nodes. How should this case be managed?

Rights and Permissions

Citation: N Engl J Med. 2010 May 27;362(21):1993-2000. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID