Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination
Department of Pediatrics; Program in Molecular Medicine
Adolescent; B-Lymphocytes; Cell Proliferation; Female; HIV Infections; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B Vaccines; Humans; Immunologic Memory; Longitudinal Studies; Male; Young Adult
Immunology and Infectious Disease | Pediatrics
Hepatitis B-specific memory B cell (HSMBC) frequencies were measured following hepatitis B vaccination in 15 HIV uninfected and 12 HIV infected adolescents. HSMBC were detected at significantly lower frequencies in HIV infected than in HIV uninfected individuals. The detection of HBsAb >10mIU/ml at study week 28 was strongly associated with the detection of HSMBC and a direct correlation between HBsAb titers and HSMBC frequencies was observed. In HIV uninfected individuals, antibody titers >1000mIU/ml were associated with higher HSMC frequencies. Lower HSMBC frequencies, reduced memory B cell (MBC) proliferation, and altered B cell phenotypes were measured in viremic HIV infected individuals compared with aviremic HIV infected or HIV uninfected individuals.
DOI of Published Version
Vaccine. 2010 May 7;28(21):3672-8. Epub 2010 Mar 28. Link to article on publisher's site
Mehta N, Cunningham CK, Flynn P, Pepe JA, Obaro S, Kapogiannis BG, Bethel J, Luzuriaga K. (2010). Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination. Immunology/Infectious Disease. https://doi.org/10.1016/j.vaccine.2010.03.022. Retrieved from https://escholarship.umassmed.edu/peds_immunology/64