Title

On the dynamics of acute EBV infection and the pathogenesis of infectious mononucleosis

UMMS Affiliation

Department of Pediatrics; Program in Molecular Medicine

Publication Date

2008-02-01

Document Type

Article

Subjects

Acute Disease; Cell Proliferation; Cytotoxicity, Immunologic; Herpesvirus 4, Human; Immunologic Memory; Infectious Mononucleosis; Time Factors

Disciplines

Immunology and Infectious Disease | Pediatrics

Abstract

Memory B cells latently infected with Epstein-Barr virus (mB(Lats)) in the blood disappear rapidly on presentation with acute symptomatic primary infection (acute infectious mononucleosis [AIM]). They undergo a simple exponential decay (average half-life: 7.5 +/- 3.7 days) similar to that of normal memory B cells. The cytotoxic T lymphocyte (CTL) response to immediate early (IE) lytic antigens (CTL(IEs)) also decays over this time period, but no such correlation was observed for the CTL response to lytic or latent antigens or to the levels of virions shed into saliva. We have estimated the average half-life of CTL(IEs) to be 73 (+/- 23) days. We propose that cycles of infection and reactivation occur in the initial stages of infection that produce high levels of mB(Lats) in the circulation. Eventually the immune response arises and minimizes these cycles leaving the high levels of mB(Lats) in the blood to decay through simple memory B-cell homeostasis mechanisms. This triggers the cells to reactivate the virus whereupon most are killed by CTL(IEs) before they can release virus and infect new cells. The release of antigens caused by this large-scale destruction of infected cells may trigger the symptoms of AIM and be a cofactor in other AIM-associated diseases.

DOI of Published Version

10.1182/blood-2007-06-093278

Source

Blood. 2008 Feb 1;111(3):1420-7. Epub 2007 Nov 8. Link to article on publisher's site

Journal/Book/Conference Title

Blood

Related Resources

Link to Article in PubMed

PubMed ID

17991806

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