Treatment of human immunodeficiency virus 1-infected infants and children with the protease inhibitor nelfinavir mesylate

UMMS Affiliation

Department of Pediatrics

Publication Date


Document Type



Adolescent; Anti-HIV Agents; CD4 Lymphocyte Count; Child; Child, Preschool; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; *HIV-1; Humans; Infant; Male; Nelfinavir; RNA, Viral; Reverse Transcriptase Inhibitors


Immunology and Infectious Disease | Pediatrics


An open-label study was conducted of nelfinavir mesylate, given with reverse transcriptase inhibitors to human immunodeficiency virus 1 (HIV-1)-infected infants and children 3 months to 13 years of age. Doses of nelfinavir mesylate of 20-30 mg/kg yielded drug exposures comparable to those seen in adults. The drug was well tolerated; mild diarrhea was the primary toxic effect observed. Seventy-one percent (39) of the 55 evaluable subjects had an initial decrease in plasma HIV-1 RNA, of at least 0.7 log10 copies/mL; suppression of plasma HIV-1 RNA levels to < 400 copies/mL was observed in 15. Children who began taking at least one new reverse transcriptase inhibitor near the time when nelfinavir mesylate was started, and those with a > or = 24% proportion of CD4 lymphocytes, had a greater chance of achieving and maintaining a decline in plasma HIV-1 RNA to < 400 copies/mL. Suppression of viremia was achieved in children as young as 3 months of age.

DOI of Published Version



Clin Infect Dis. 1999 May;28(5):1109-18. Link to article on publisher's site

Journal/Book/Conference Title

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Related Resources

Link to Article in PubMed

PubMed ID