Title

Immunoprophylaxis to prevent mother-to-child transmission of HIV-1

UMMS Affiliation

Department of Pediatrics; Program in Molecular Medicine

Publication Date

2-1-2004

Document Type

Article

Subjects

*AIDS Vaccines; Acquired Immunodeficiency Syndrome; Animals; Breast Feeding; Female; HIV Antibodies; HIV-1; Humans; Immunization, Passive; Infant, Newborn; Infectious Disease Transmission, Vertical; Milk, Human; Pregnancy

Disciplines

Immunology and Infectious Disease | Pediatrics

Abstract

Antiretroviral therapy can profoundly reduce the risk of mother-to-child transmission (MTCT) of HIV, but the drugs have a relatively short half-life and should thus be administered throughout breast-feeding to optimally prevent postnatal infection of the infant. The potential toxicities and the development of resistance may limit the long-term efficacy of antiretroviral prophylaxis, and a safe and effective active/passive immunoprophylaxis regimen, begun at birth, and potentially overlapping with interpartum or neonatal chemoprophylaxis, would pose an attractive alternative. This review draws on data presented at the Ghent Workshop on prevention of breast milk transmission and on selected issues from a workshop specifically relating to immunoprophylaxis held in Seattle in October 2002. This purpose of this review is to address the scientific rationale for the development of passive (antibody) and active (vaccine) immunization strategies for prevention of MTCT. Data regarding currently or imminently available passive and active immunoprophylaxis products are reviewed for their potential use in neonatal trials within the coming 1-2 years.

Source

J Acquir Immune Defic Syndr. 2004 Feb 1;35(2):169-77.

Journal/Book/Conference Title

Journal of acquired immune deficiency syndromes (1999)

Related Resources

Link to Article in PubMed

PubMed ID

14722451

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