Platelet function monitoring in patients with coronary artery disease
Department of Pediatrics
Medical Subject Headings
Acute Coronary Syndrome; Aspirin; Coronary Artery Disease; Coronary Disease; Drug Resistance; Humans; *Monitoring, Physiologic; Myocardial Infarction; Platelet Aggregation Inhibitors; *Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Risk Factors; Ticlopidine; Treatment Outcome
Hematology | Oncology | Pediatrics
Studies focused on patient responsiveness to antiplatelet therapies, particularly aspirin and clopidogrel, have increased in recent years. However, the relations of in vivo platelet function and adverse clinical events to results of ex vivo platelet function tests remain largely unknown. This article describes current methods of measuring platelet function in various clinical and research situations and their advantages and disadvantages, reviews evidence for antiplatelet response variability and resistance, discusses the potential pitfalls of monitoring platelet function, and demonstrates emerging data supporting the positive clinical and treatment implications of platelet function testing.
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Citation: J Am Coll Cardiol. 2007 Nov 6;50(19):1822-34. Epub 2007 Oct 23. doi:10.1016/j.jacc.2007.07.051
Gurbel, Paul A.; Becker, Richard C.; Mann, Kenneth G.; Steinhubl, Steven R.; and Michelson, Alan D., "Platelet function monitoring in patients with coronary artery disease" (2007). Hematology/Oncology. 96.