eScholarship@UMMS

Title

Indices of platelet activation and the stability of coronary artery disease

Authors

Matthew Dean Linden, University of Massachusetts Medical SchoolFollow
Mark I. Furman, University of Massachusetts Medical School
Andrew L. Frelinger III, University of Massachusetts Medical SchoolFollow
Marsha L. Fox, University of Massachusetts Medical SchoolFollow
Marc R. Barnard, University of Massachusetts Medical SchoolFollow
YouFu Li, University of Massachusetts Medical SchoolFollow
Karin Przyklenk, University of Massachusetts Medical SchoolFollow
Alan D. Michelson, University of Massachusetts Memorial Medical CenterFollow

UMMS Affiliation

Department of Pediatrics; Department of Emergency Medicine; Department of Anesthesiology

Publication Date

2007-4

Document Type

Article

Subjects

Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; CD40 Ligand; Coronary Artery Disease; Epinephrine; Female; Humans; Male; Middle Aged; Neutrophils; P-Selectin; *Platelet Activation; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex

Disciplines

Hematology | Oncology | Pediatrics

Abstract

AIM: To determine whether indices of platelet activation are associated with the stability of coronary artery disease (CAD).

METHODS: Platelet function was examined in 677 consecutive aspirin-treated patients presenting for cardiac catheterization. Patients were grouped into recent myocardial infarction (MI), no MI but angiographically documented CAD (non-MI CAD) and no angiographically detectible CAD (no CAD), as well as additional subgroups.

RESULTS: Compared with non-MI CAD or no CAD patients, more patients with recent MI had a shortened platelet function analyzer (PFA)-100 collagen-epinephrine closure time (CT) and increased circulating monocyte-platelet aggregates, neutrophil-platelet aggregates, activated platelet surface GPIIb-IIIa and plasma soluble CD40 ligand (sCD40L). More patients with non-MI CAD had shortened PFA-100 CTs and increased monocyte-platelet aggregates compared with patients with no CAD. Platelet surface P-selectin did not differ among the groups. Subgroup analysis revealed that decreasing PFA-100 CT correlated with the stability of CAD.

CONCLUSIONS: Indices of platelet activation, especially the PFA-100 CT, are associated with the stability of CAD, and may reflect plaque instability, an ongoing thrombotic state and/or reduced responsiveness to aspirin.

DOI of Published Version

10.1111/j.1538-7836.2007.02462.x

Source

J Thromb Haemost. 2007 Apr;5(4):761-5. Epub 2007 Feb 26. doi: 10.1111/j.1538-7836.2007.02462.x

Journal/Book/Conference Title

Journal of thrombosis and haemostasis : JTH

Related Resources

Link to article in PubMed

PubMed ID

17371489

Repository Citation

Linden MD, Furman MI, Frelinger AL, Fox ML, Barnard MR, Li Y, Przyklenk K, Michelson AD. (2007). Indices of platelet activation and the stability of coronary artery disease. Hematology/Oncology. https://doi.org/10.1111/j.1538-7836.2007.02462.x. Retrieved from https://escholarship.umassmed.edu/peds_hematology/93