Title
Clopidogrel linking evaluation of platelet response variability to mechanism of action
UMMS Affiliation
Department of Pediatrics
Publication Date
2005-8
Document Type
Article
Subjects
Blood Platelets; Cardiovascular Diseases; Humans; Platelet Aggregation Inhibitors; *Platelet Function Tests; Ticlopidine; Time Factors; Treatment Outcome
Disciplines
Hematology | Oncology | Pediatrics
Abstract
The antiplatelet agent clopidogrel, given alone or in addition to aspirin, is effective in reducing the composite end point of death from cardiovascular causes, nonfatal myocardial infarction, or stroke in patients with acute coronary syndromes. However, many patients receiving clopidogrel still sustain these poor outcomes. Furthermore, laboratory assays of platelet response(s) to clopidogrel show wide interindividual variability, with some patients being classified as “nonresponders” or “resistant” to clopidogrel. Understanding why these assays give such different results is essential to their possible future utility as guides to therapeutic decision-making and new drug development.
DOI of Published Version
10.1016/j.jacc.2005.05.039
Source
J Am Coll Cardiol. 2005 Aug 16;46(4):646-7. doi 10.1016/j.jacc.2005.05.039
Journal/Book/Conference Title
Journal of the American College of Cardiology
Related Resources
PubMed ID
16098429
Repository Citation
Frelinger, Andrew L. III and Michelson, Alan D., "Clopidogrel linking evaluation of platelet response variability to mechanism of action" (2005). Hematology/Oncology. 68.
https://escholarship.umassmed.edu/peds_hematology/68