A panorama of lineage-specific transcription in hematopoiesis

UMMS Affiliation

Department of Pediatrics

Publication Date


Document Type



Animals; Cell Differentiation; Cell Lineage; Gene Expression Profiling; *Gene Expression Regulation, Developmental; Hematopoiesis; Hematopoietic Stem Cells; Humans; Transcription Factors; *Transcription, Genetic


Hematology | Oncology | Pediatrics


The hematopoietic system consists of more than ten differentiated cell types, all of which are derived from a single type of hematopoietic stem cell. The accessibility and interest of this system have made it a model for understanding normal and abnormal differentiation of mammalian cells. Newer techniques have generated a mass of data that requires integrative approaches for analysis and interpretation. The traditional view of the differentiation program holds that a small number of regulators are involved in each stage of cell specification. However, this may not be the case. Recent analyses have shown that almost all substantial subsets of genes, including the set of broadly expressed transcription factors, are expressed in patterns that are unique for each lineage. Further, much of this difference between lineages can be captured in two-dimensional graphs. Understanding the biologic significance, mechanisms and constraints underlying these differences is a challenge for experimentalists and computational biologists alike.

DOI of Published Version



Bioessays. 2004 Dec;26(12):1276-87. doi 10.1002/bies.20144

Journal/Book/Conference Title

BioEssays : news and reviews in molecular, cellular and developmental biology

Related Resources

Link to article in PubMed

PubMed ID