Platelet reactivity and the identification of acute coronary syndromes in the emergency department

UMMS Affiliation

Department of Pediatrics; Department of Emergency Medicine

Publication Date


Document Type



Acute Coronary Syndrome; Biological Markers; Emergency Medical Services; Humans; *Platelet Activation; Platelet Function Tests; Sensitivity and Specificity; Time Factors


Hematology | Oncology | Pediatrics


Risk stratifying patients with potential acute coronary syndromes (ACS) in the Emergency Department is an imprecise and resource-consuming process. ACS cannot be ruled in or out efficiently in a majority of patients after initial history, physical exam, and ECG are analyzed. This has led to a reliance on cardiac markers of myocardial necrosis as a key means of making the diagnosis. Commonly used markers, CK-MB and troponin-I, have the drawback of delayed sensitivity. This has led to an ongoing search for one or more marker(s) that would be more sensitive in early ACS. With the central role that platelets play in the pathophysiology of coronary thrombosis, measures of platelet function represent one potential area where an early ACS marker might be identified. This review will focus on selected tests/markers of platelet function that have shown some promise with respect to the risk stratification of patients with potential ACS.

DOI of Published Version



J Thromb Thrombolysis. 2009 Jul;28(1):31-7. Epub 2008 Jul 4. Link to article on publisher's website

Journal/Book/Conference Title

Journal of thrombosis and thrombolysis

Related Resources

Link to article in PubMed

PubMed ID