Title
Platelet reactivity and the identification of acute coronary syndromes in the emergency department
UMMS Affiliation
Department of Pediatrics; Department of Emergency Medicine
Publication Date
2009-07-05
Document Type
Article
Subjects
Acute Coronary Syndrome; Biological Markers; Emergency Medical Services; Humans; *Platelet Activation; Platelet Function Tests; Sensitivity and Specificity; Time Factors
Disciplines
Hematology | Oncology | Pediatrics
Abstract
Risk stratifying patients with potential acute coronary syndromes (ACS) in the Emergency Department is an imprecise and resource-consuming process. ACS cannot be ruled in or out efficiently in a majority of patients after initial history, physical exam, and ECG are analyzed. This has led to a reliance on cardiac markers of myocardial necrosis as a key means of making the diagnosis. Commonly used markers, CK-MB and troponin-I, have the drawback of delayed sensitivity. This has led to an ongoing search for one or more marker(s) that would be more sensitive in early ACS. With the central role that platelets play in the pathophysiology of coronary thrombosis, measures of platelet function represent one potential area where an early ACS marker might be identified. This review will focus on selected tests/markers of platelet function that have shown some promise with respect to the risk stratification of patients with potential ACS.
DOI of Published Version
10.1007/s11239-008-0242-x
Source
J Thromb Thrombolysis. 2009 Jul;28(1):31-7. Epub 2008 Jul 4. Link to article on publisher's website
Journal/Book/Conference Title
Journal of thrombosis and thrombolysis
Related Resources
PubMed ID
18600429
Repository Citation
Darling, Chad E.; Michelson, Alan D.; Volturo, Gregory A.; and Przyklenk, Karin, "Platelet reactivity and the identification of acute coronary syndromes in the emergency department" (2009). Hematology/Oncology. 122.
https://escholarship.umassmed.edu/peds_hematology/122