Investigating the mechanisms of hyporesponse to antiplatelet approaches
Authors
Braunwald, EugeneAngiolillo, Dominick J.
Bates, Eric
Berger, Peter B.
Bhatt, Deepak
Cannon, Christopher P.
Furman, Mark I.
Gurbel, Paul A.
Michelson, Alan D.
Peterson, Eric D.
Wiviott, Stephen D.
UMass Chan Affiliations
Department of PediatricsDocument Type
Journal ArticlePublication Date
2008-03-01Keywords
AspirinBlood Platelets
*Drug Resistance
Drug Therapy, Combination
Genetic Predisposition to Disease
Humans
Patient Selection
Platelet Aggregation Inhibitors
*Platelet Function Tests
Risk Assessment
Risk Factors
Ticlopidine
Treatment Outcome
Hematology
Oncology
Pediatrics
Metadata
Show full item recordAbstract
Hyporesponsiveness, or resistance, to antiplatelet therapy may be a major contributor to poorer outcomes among cardiac patients and may be attributed to an array of mechanisms--both modifiable and unmodifiable. Recent evidence has uncovered clinical, cellular, and genetic factors associated with hyporesponsiveness. Patients with severe acute coronary syndromes (ACS), type 2 diabetes, and increased body mass index appear to be the most at risk for hyporesponsiveness. Addressing modifiable mechanisms may offset hyporesponsiveness, while recognizing unmodifiable mechanisms, such as genetic polymorphisms and diseases that affect response to antiplatelet therapy, may help identify patients who are more likely to be hyporesponsive. Hyporesponsive patients might benefit from different dosing strategies or additional antiplatelet therapies. Trials correlating platelet function test results to clinical outcomes are required. Results from these studies could cause a paradigm shift toward individualized antiplatelet therapy, improving predictability of platelet inhibition, and diminishing the likelihood for hyporesponsiveness.Source
Clin Cardiol. 2008 Mar;31(3 Suppl 1):I21-7. doi 10.1002/clc.20360DOI
10.1002/clc.20360Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43303PubMed ID
18481819Related Resources
Link to article in PubMedae974a485f413a2113503eed53cd6c53
10.1002/clc.20360