Deletion 22q11: spectrum of associated disorders

UMMS Affiliation

Department of Pediatrics



Document Type


Medical Subject Headings

*Chromosome Deletion; Chromosomes, Human, Pair 22; DiGeorge Syndrome; Humans


Genetics and Genomics | Medical Genetics | Pediatrics


Velocardiofacial syndrome, also called Shprintzen syndrome or DiGeorge sequence, is one of the most common genetic disorders in humans. Caused by a microdeletion on chromosome 22, it manifests in a remarkable variety of symptoms in multiple systems. The most frequent anomalies involve palatal function, facial features and congenital cardiac defects. In addition, learning disabilities and psychiatric issues are common. The aim of this article is to provide a concise review of the clinical characteristics of this complex disorder. Recognition of the features associated with velocardiofacial syndrome allows for an inclusive diagnosis and more comprehensive care.

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Citation: Semin Pediatr Neurol. 2007 Sep;14(3):136-9. Link to article on publisher's site

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