Long-term minocycline use for acne in healthy adolescents can cause severe autoimmune hepatitis

UMMS Affiliation

Department of Pediatrcis; Department of Pathology



Document Type


Medical Subject Headings

Acne Vulgaris; Adolescent; Anti-Bacterial Agents; Drug-Induced Liver Injury, Chronic; Female; Hepatitis, Autoimmune; Humans; Male; Minocycline; Severity of Illness Index


Gastroenterology | Pediatrics


Over the years, a variety of abnormal immune reactions to minocycline have been reported including arthritis, systemic lupus erythematosus, and hepatitis. The current report describes the detailed clinical and pathologic features of 3 patients who presented with chronic/autoimmune hepatitis alone while on minocycline at our hospital over a 2-year period. Minocycline use in these patients was temporally related to onset of severe hepatitis. Adolescents with such a reaction to minocycline have been included in previous reports but have not been well described as a distinct entity. We have compared our cases with similar cases previously reported with a review of the literature and a discussion of the implications for prescribing physicians.

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Citation: J Clin Gastroenterol. 2009 Sep;43(8):787-90. Link to article on publisher's site

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