Partial clinical remission in type 1 diabetes: a comparison of the accuracy of total daily dose of insulin of <0.3 units/kg/day to the gold standard insulin-dose adjusted hemoglobin A1c of ≤9 for the detection of partial clinical remission
Department of Pediatrics, Division of Endocrinology; Department of Quantitative Health Sciences; Department of Medicine, Division of Diabetes; UMass Metabolic Network
Endocrine System Diseases | Endocrinology, Diabetes, and Metabolism | Pediatrics
BACKGROUND: It is unclear whether the gold standard test for the detection of partial clinical remission (PCR) in new-onset type 1 diabetes (T1D), the insulin-dose adjusted Hemoglobin A1c (IDAA1c) of ≤9, is superior to a new tool, total daily dose of insulin (TDD) of
METHODS: A retrospective analysis of 204 subjects of ages 2-14 years, mean age 7.9±3.2 years, (male 7.8±3.4 years, [n=98]; female 7.9±3.0 years, [n=106], p=0.816) with new-onset T1D. Anthropometric and biochemical data were collected for the first 36 months of disease. PCR was defined by both IDAA1c≤9 and TDD
RESULTS: There were 86 (42.2%) (age 9.1±3.0 years; male 57%) remitters by IDAA1c≤9 criterion, and 82 (40.2%) remitters (age 7.3±2.8 years) by TDD of
CONCLUSIONS: There were no significant differences in the number of remitters, duration of PCR, or the time of peak remission defined by IDAA1c of ≤9 or TDD of
bicarbonate, children and adolescents, hemoglobin A1c, honeymoon period, insulin, type 1 diabetes
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DOI of Published Version
J Pediatr Endocrinol Metab. 2017 Aug 28;30(8):823-830. doi: 10.1515/jpem-2017-0019. First published online 28 July 2017. Link to article on publisher's website
Journal of pediatric endocrinology and metabolism : JPEM
Lundberg, Rachel L.; Marino, Katherine R.; Jasrotia, Aastha; Maranda, Louise S.; Barton, Bruce A.; Alonso, Laura C.; and Nwosu, Benjamin U., "Partial clinical remission in type 1 diabetes: a comparison of the accuracy of total daily dose of insulin of <0.3 units/kg/day to the gold standard insulin-dose adjusted hemoglobin A1c of ≤9 for the detection of partial clinical remission" (2017). Endocrinology/Diabetes. 62.