UMMS Affiliation

Department of Pediatrics, Division of Endocrinology; Department of Quantitative Health Sciences; Department of Medicine, Division of Diabetes; UMass Metabolic Network

Publication Date


Document Type



Endocrine System Diseases | Endocrinology, Diabetes, and Metabolism | Pediatrics


BACKGROUND: It is unclear whether the gold standard test for the detection of partial clinical remission (PCR) in new-onset type 1 diabetes (T1D), the insulin-dose adjusted Hemoglobin A1c (IDAA1c) of ≤9, is superior to a new tool, total daily dose of insulin (TDD) of

METHODS: A retrospective analysis of 204 subjects of ages 2-14 years, mean age 7.9±3.2 years, (male 7.8±3.4 years, [n=98]; female 7.9±3.0 years, [n=106], p=0.816) with new-onset T1D. Anthropometric and biochemical data were collected for the first 36 months of disease. PCR was defined by both IDAA1c≤9 and TDD

RESULTS: There were 86 (42.2%) (age 9.1±3.0 years; male 57%) remitters by IDAA1c≤9 criterion, and 82 (40.2%) remitters (age 7.3±2.8 years) by TDD of

CONCLUSIONS: There were no significant differences in the number of remitters, duration of PCR, or the time of peak remission defined by IDAA1c of ≤9 or TDD of


bicarbonate, children and adolescents, hemoglobin A1c, honeymoon period, insulin, type 1 diabetes

Rights and Permissions

©2017 Walter de Gruyter GmbH, Berlin/Boston. Publisher PDF posted after 12 months as allowed by the publisher's author rights policy at

DOI of Published Version



J Pediatr Endocrinol Metab. 2017 Aug 28;30(8):823-830. doi: 10.1515/jpem-2017-0019. First published online 28 July 2017. Link to article on publisher's website

Journal/Book/Conference Title

Journal of pediatric endocrinology and metabolism : JPEM

Related Resources

Link to article in PubMed

PubMed ID