UMass Chan Affiliations
Department of PediatricsDocument Type
Journal ArticlePublication Date
2009-03-01Keywords
Antipsychotic AgentsHyperglycemia
Diabetes Mellitus, Type 1
Endocrinology, Diabetes, and Metabolism
Pediatrics
Metadata
Show full item recordAbstract
Atypical or second-generation antipsychotic agents, such as aripiprazole and olanzapine, are increasingly used in the management of schizophrenia and bipolar disorders in children. The atypical antipsychotic agents have been associated with the development of hyperglycemia, ketoacidosis, and diabetes. The mechanism of atypical antipsychotic-mediated hyperglycemia is unclear. Most of the published reports have been on individuals at risk for type 2 diabetes. We present the first known cases of the development of diabetes and positive glutamic acid decarboxylase antibodies (suggestive of autoimmune diabetes) in adolescents while on treatment with atypical antipsychotics. The nature of their clinical presentations and the time course of antipsychotic therapy to clinical diagnosis of diabetes make us speculate that atypical antipsychotics may shorten the time course of the development of autoimmune diabetes in predisposed children.Source
Nwosu BU, Soyka LA, Angelescu A, Hardy OT, Lee MM. Do Atypical Antipsychotic Agents Trigger Autoimmune Diabetes in Adolescents? The Endocrinologist, 2009, 19:85-87. DOI: 10.1097/TEN.0b013e318198b9b8DOI
10.1097/TEN.0b013e318198b9b8Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43233ae974a485f413a2113503eed53cd6c53
10.1097/TEN.0b013e318198b9b8