The nondietary determinants of vitamin D status in pediatric inflammatory bowel disease

UMMS Affiliation

Department of Pediatrics; Department of Quantitative Health Sciences



Document Type



Dietetics and Clinical Nutrition | Digestive System Diseases | Endocrinology, Diabetes, and Metabolism | Pediatrics


OBJECTIVES: The aim of this study was to investigate the relationships between 25-hydroxy vitamin D (25[OH]D) and markers of vitamin D status in inflammatory bowel disease (IBD).

METHODS: We conducted a retrospective case-control study of 59 pediatric patients with IBD (age 16.4 ± 2.2 y) and 116 controls (age 14.6 ± 4.4 y), to investigate the association between 25(OH)D and albuminemia for protein-losing enteropathy (PLE) and hepatic dysfunction; alanine transaminase (ALT) for hepatic inflammation; erythrocyte sedimentation rate (ESR) for intestinal inflammation; body mass index (BMI) for adiposity; seasons and skin pigmentation for insolation. Vitamin D deficiency was defined as 25(OH)D < 50 nmol/L; abnormal liver enzyme by ALT >40 U/L; overweight status by BMI of ≥85th but <95th >percentile, and obesity by BMI ≥95th percentile. Seasons were categorized as summer, winter, spring, and fall.

RESULTS: Patients with IBD had a higher prevalence of vitamin D deficiency (42.4% versus 26.7%; P = 0.04), elevated ALT (16.9% versus 2.6%; P < 0.001), and lower albumin (41.1 ± 4.8 versus 45.1 ± 3.8; P < 0.001) than controls. In both the IBD cohort and controls, 25(OH)D was highest in summer and lowest in winter, and significantly higher in white than in non-white patients. ESR varied significantly with 25(OH)D (R(2) = 0.24; β = -0.32; P = 0.010), and only patients with IBD with elevated ESR had lower 25(OH)D than controls (49.5 ± 25.2 versus 65.3 ± 28.0 nmol/L; P = 0.045).

CONCLUSION: Intestinal inflammation, not the loss of albumin-bound vitamin D in the gut, is the primary intestinal determinant of vitamin D status in IBD. The extraintestinal determinants are seasons and skin pigmentation, but not adiposity and hepatic inflammation.


Citation: Veit LE, Maranda L, Nwosu BU. The nondietary determinants of vitamin D status in pediatric inflammatory bowel disease. Nutrition. 2015 Jul-Aug;31(7-8):994-9. doi: 10.1016/j.nut.2015.03.010. Epub 2015 Apr 20. PubMed PMID: 26059374. Link to article on publisher's site

Related Resources

Link to article in PubMed


Adiposity, Alanine transaminase, Crohn's disease, Hepatic inflammation, Hypoalbuminemia, Inflammatory bowel disease, Intestinal inflammation, Protein-losing enteropathy, Ulcerative colitis, Vitamin D

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