Title
Association between chlorinated pesticides in the serum of prepubertal Russian boys and longitudinal biomarkers of metabolic function
UMMS Affiliation
Department of Pediatrics; Department of Cell and Developmental Biology
Publication Date
2014-11-01
Document Type
Article
Subjects
Adolescent; Biological Markers; Blood Glucose; Child; Cholesterol; Humans; Hydrocarbons, Chlorinated; Insulin; *Insulin Resistance; Leptin; Male; Metabolic Syndrome X; Pesticides; Prospective Studies; Regression Analysis; Triglycerides
Disciplines
Disorders of Environmental Origin | Endocrine System Diseases | Endocrinology, Diabetes, and Metabolism | Medical Toxicology | Pediatrics | Reproductive and Urinary Physiology | Toxicology
Abstract
Organochlorine pesticides (OCPs) have been linked to adult metabolic disorders; however, few studies have examined these associations in childhood. We prospectively evaluated the associations of baseline serum OCPs (hexachlorobenzene, beta-hexachlorocyclohexane, and p,p'-dichlorodiphenyldichloroethylene) in Russian boys with subsequent repeated measurements of serum glucose, insulin, lipids, leptin, and calculated homeostatic model assessment of insulin resistance (IR). During 2003-2005, we enrolled 499 boys aged 8-9 years in a prospective cohort; 318 had baseline serum OCPs and serum biomarkers measured at ages 10-13 years. Multivariable generalized estimating equation and mediation regression models were used to examine associations and direct and indirect (via body mass index (BMI) (weight (kg)/height (m)(2))) effects of prepubertal OCP tertiles and quintiles with biomarkers. In multivariable models, higher p,p'-dichlorodiphenyldichloroethylene (quintile 5 vs. quintile 1) was associated with lower leptin, with relative mean decreases of 61.8% (95% confidence interval: 48.4%, 71.7%) in models unadjusted for BMI and 22.2% (95% confidence interval: 7.1%, 34.9%) in models adjusted for BMI; the direct effect of p,p'-dichlorodiphenyldichloroethylene on leptin accounted for 27% of the total effect. IR prevalence was 6.6% at ages 12-13 years. Higher hexachlorobenzene (tertile 3 vs. tertile 1) was associated with higher odds of IR in models adjusted for BMI (odds ratio = 4.37, 95% confidence interval: 1.44, 13.28). These results suggest that childhood OCPs may be associated with IR and lower leptin.
Keywords
children, insulin resistance, leptin, metabolism, pesticides
DOI of Published Version
10.1093/aje/kwu212
Source
Am J Epidemiol. 2014 Nov 1;180(9):909-19. doi: 10.1093/aje/kwu212. Epub 2014 Sep 25. Link to article on publisher's site
Journal/Book/Conference Title
American journal of epidemiology
Related Resources
PubMed ID
25255811
Repository Citation
Burns JS, Williams PL, Korrick SA, Hauser R, Sergeyev O, Revich B, Lam T, Lee MM. (2014). Association between chlorinated pesticides in the serum of prepubertal Russian boys and longitudinal biomarkers of metabolic function. Endocrinology/Diabetes. https://doi.org/10.1093/aje/kwu212. Retrieved from https://escholarship.umassmed.edu/peds_endocrinology/50