Association between chlorinated pesticides in the serum of prepubertal Russian boys and longitudinal biomarkers of metabolic function
Department of Pediatrics; Department of Cell and Developmental Biology
Adolescent; Biological Markers; Blood Glucose; Child; Cholesterol; Humans; Hydrocarbons, Chlorinated; Insulin; *Insulin Resistance; Leptin; Male; Metabolic Syndrome X; Pesticides; Prospective Studies; Regression Analysis; Triglycerides
Disorders of Environmental Origin | Endocrine System Diseases | Endocrinology, Diabetes, and Metabolism | Medical Toxicology | Pediatrics | Reproductive and Urinary Physiology | Toxicology
Organochlorine pesticides (OCPs) have been linked to adult metabolic disorders; however, few studies have examined these associations in childhood. We prospectively evaluated the associations of baseline serum OCPs (hexachlorobenzene, beta-hexachlorocyclohexane, and p,p'-dichlorodiphenyldichloroethylene) in Russian boys with subsequent repeated measurements of serum glucose, insulin, lipids, leptin, and calculated homeostatic model assessment of insulin resistance (IR). During 2003-2005, we enrolled 499 boys aged 8-9 years in a prospective cohort; 318 had baseline serum OCPs and serum biomarkers measured at ages 10-13 years. Multivariable generalized estimating equation and mediation regression models were used to examine associations and direct and indirect (via body mass index (BMI) (weight (kg)/height (m)(2))) effects of prepubertal OCP tertiles and quintiles with biomarkers. In multivariable models, higher p,p'-dichlorodiphenyldichloroethylene (quintile 5 vs. quintile 1) was associated with lower leptin, with relative mean decreases of 61.8% (95% confidence interval: 48.4%, 71.7%) in models unadjusted for BMI and 22.2% (95% confidence interval: 7.1%, 34.9%) in models adjusted for BMI; the direct effect of p,p'-dichlorodiphenyldichloroethylene on leptin accounted for 27% of the total effect. IR prevalence was 6.6% at ages 12-13 years. Higher hexachlorobenzene (tertile 3 vs. tertile 1) was associated with higher odds of IR in models adjusted for BMI (odds ratio = 4.37, 95% confidence interval: 1.44, 13.28). These results suggest that childhood OCPs may be associated with IR and lower leptin.
children, insulin resistance, leptin, metabolism, pesticides
DOI of Published Version
Am J Epidemiol. 2014 Nov 1;180(9):909-19. doi: 10.1093/aje/kwu212. Epub 2014 Sep 25. Link to article on publisher's site
American journal of epidemiology
Burns, Jane S.; Williams, Paige L.; Korrick, Susan A.; Hauser, Russ; Sergeyev, Oleg; Revich, Boris; Lam, Thuy; and Lee, Mary M., "Association between chlorinated pesticides in the serum of prepubertal Russian boys and longitudinal biomarkers of metabolic function" (2014). Endocrinology/Diabetes. 50.