Association between chlorinated pesticides in the serum of prepubertal Russian boys and longitudinal biomarkers of metabolic function
Authors
Burns, Jane S.Williams, Paige L.
Korrick, Susan A.
Hauser, Russ
Sergeyev, Oleg
Revich, Boris
Lam, Thuy
Lee, Mary M.
Document Type
Journal ArticlePublication Date
2014-11-01Keywords
AdolescentBiological Markers
Blood Glucose
Child
Cholesterol
Humans
Hydrocarbons, Chlorinated
Insulin
*Insulin Resistance
Leptin
Male
Metabolic Syndrome X
Pesticides
Prospective Studies
Regression Analysis
Triglycerides
children
insulin resistance
leptin
metabolism
pesticides
Disorders of Environmental Origin
Endocrine System Diseases
Endocrinology, Diabetes, and Metabolism
Medical Toxicology
Pediatrics
Reproductive and Urinary Physiology
Toxicology
Metadata
Show full item recordAbstract
Organochlorine pesticides (OCPs) have been linked to adult metabolic disorders; however, few studies have examined these associations in childhood. We prospectively evaluated the associations of baseline serum OCPs (hexachlorobenzene, beta-hexachlorocyclohexane, and p,p'-dichlorodiphenyldichloroethylene) in Russian boys with subsequent repeated measurements of serum glucose, insulin, lipids, leptin, and calculated homeostatic model assessment of insulin resistance (IR). During 2003-2005, we enrolled 499 boys aged 8-9 years in a prospective cohort; 318 had baseline serum OCPs and serum biomarkers measured at ages 10-13 years. Multivariable generalized estimating equation and mediation regression models were used to examine associations and direct and indirect (via body mass index (BMI) (weight (kg)/height (m)(2))) effects of prepubertal OCP tertiles and quintiles with biomarkers. In multivariable models, higher p,p'-dichlorodiphenyldichloroethylene (quintile 5 vs. quintile 1) was associated with lower leptin, with relative mean decreases of 61.8% (95% confidence interval: 48.4%, 71.7%) in models unadjusted for BMI and 22.2% (95% confidence interval: 7.1%, 34.9%) in models adjusted for BMI; the direct effect of p,p'-dichlorodiphenyldichloroethylene on leptin accounted for 27% of the total effect. IR prevalence was 6.6% at ages 12-13 years. Higher hexachlorobenzene (tertile 3 vs. tertile 1) was associated with higher odds of IR in models adjusted for BMI (odds ratio = 4.37, 95% confidence interval: 1.44, 13.28). These results suggest that childhood OCPs may be associated with IR and lower leptin.Source
Am J Epidemiol. 2014 Nov 1;180(9):909-19. doi: 10.1093/aje/kwu212. Epub 2014 Sep 25. Link to article on publisher's siteDOI
10.1093/aje/kwu212Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43227PubMed ID
25255811Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1093/aje/kwu212