Department of Pediatrics; Department of Quantitative Health Sciences; Senior Scholars Program
Digestive System Diseases | Endocrinology, Diabetes, and Metabolism | Gastroenterology | Pediatrics
Background. It is unknown whether the coexistence of type 1 diabetes (T1D) and celiac disease (CD) increases the risk for vitamin D deficiency.
Aims. To determine the vitamin D status and the risk for vitamin D deficiency in prepubertal children with both T1D and CD compared to controls, TID, and CD.
Subjects and Methods. Characteristics of 62 prepubertal children of age 2–13 y with either CD + T1D (� = 22, 9.9 ± 3.1 y), CD only (� = 18, 8.9 ± 3.3 y), or T1D only (� = 22, 10.1 ± 2.8 y) were compared to 49 controls of the age of 8.0 ± 2.6 years. Vitamin D deficiency was defined as 25(OH)D < 50 nmol/L, overweight as BMI of > 85th but < 95th percentile, and obesity as BMI > 95th percentile.
Results. The 4 groups had no difference in 25(OH)D (ANOVA � = 0.123) before stratification into normal-weight versus overweight/obese subtypes. Following stratification, 25(OH)D differed significantly between the subgroups (�(3,98) = 10.109, ANOVA � < 0.001). Post-hoc analysis showed a significantly lower 25(OH)D in the overweight/obese CD + T1D compared to the overweight/obese controls () and the overweight/obese CD (� = 0.039) and the overweight/obese CD (� = 0.003). Subjects with CD + T1D were 3 times more likely to be vitamin D deficient (OR = 3.1 [0.8–11.9], � = 0.098), compared to controls.
Conclusions. The coexistence of T1D and CD in overweight/obese prepubertal children may be associated with lower vitamin D concentration.
Vitamin D, obesity, celiac disease, Type 1 diabetes, child
DOI of Published Version
Setty-Shah N, Maranda L, Nwosu BU. Increased risk for vitamin d deficiency in obese children with both celiac disease and type 1 diabetes. Gastroenterol Res Pract. 2014;2014:561351. doi: 10.1155/2014/561351. Epub 2014 Dec 4. PubMed PMID:25548555; PubMed Central PMCID: PMC4273505. Link to article on publisher's site
Gastroenterology Research and Practice
Setty-Shah, Nithya; Maranda, Louise S.; and Nwosu, Benjamin U., "Increased Risk for Vitamin D Deficiency in Obese Children with Both Celiac Disease and Type 1 Diabetes" (2014). Endocrinology/Diabetes. 48.
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