Department of Pediatrics
Celiac Disease; Adiposity; Obesity; Body Mass Index; Body Height; Child
Digestive System Diseases | Endocrinology, Diabetes, and Metabolism | Nutritional and Metabolic Diseases | Pediatrics
Background and Aim: The pathogenesis of short stature in celiac disease (CD) is unknown. Obese children are generally taller than their non-obese peers; however, the role of adiposity on stature in CD is unclear. Our aim was to determine the association between adiposity and stature in CD.
Subjects and methods: We compared the anthropometric characteristics of prepubertal children of ages 3-12 years, with biopsy-proven CD (n=40) and who were not on gluten-free diet, to same aged, prepubertal non-CD children (n=50). Body mass index (BMI) was calculated using the formula weight/height2. Sex-adjusted midparental target height (MPTH) standard deviation score (SDS) was calculated using National Children Health Statistics data for 18-year-old adults. Data were expressed as mean±standard deviation.
Results: CD subjects had significantly lower BMI SDS than controls (0.61±1.22 vs. 1.28±1.60, p=0.027) but were not significantly shorter than the controls (-0.05±1.21 vs. 0.21±1.71, p=0.41). When the patients were subdivided into the normal-weight and overweight/obese groups, the normal-weight CD patients were of similar height as the normal-weight controls (p=0.76) but were significantly shorter than both the overweight/obese controls (p=0.003). The MPTH SDS did not differ between the groups.
Conclusions: Overweight/obese prepubertal children with CD were taller than both their normal-weight CD peers and the normal-weight controls, but were of similar height as the overweight/obese control subjects.
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DOI of Published Version
Nwosu BU, Snook RI, Maranda L. The relationship between adiposity and stature in prepubertal children with celiac disease. J Pediatr Endocrinol Metab. 2013;26(9-10):819-24. doi: 10.1515/jpem-2012-0312. Link to article on publisher's site
Journal of pediatric endocrinology and metabolism : JPEM
Nwosu, Benjamin U.; Snook, Rachel I.; and Maranda, Louise S., "The relationship between adiposity and stature in prepubertal children with celiac disease" (2013). Endocrinology/Diabetes. 41.