Hepatic dysfunction is associated with vitamin D deficiency and poor glycemic control in diabetes mellitus

UMMS Affiliation

Department of Pediatrics; Department of Medicine

Publication Date


Document Type



Vitamin D Deficiency; Diabetes Mellitus; Fatty Liver


Endocrinology, Diabetes, and Metabolism | Pediatrics


Background/Aims: The effect of the rising prevalence of nonalcoholic fatty liver disease on the 25-hydroxylation of pre-vitamin D in the liver, and consequent glycemic control in children with diabetes mellitus is not known. Our aim was to determine whether mild hepatic dysfunction was associated with impaired 25-hydroxylation of pre-vitamin D, and if this vitamin D deficiency was associated with impaired glycemic control in children and adolescents with type 1 diabetes (TIDM) and type 2 diabetes (T2DM).

Methods: We analyzed simultaneously measured HbA1c, ALT, AST, and 25OHD levels and clinical parameters in 121 children and adolescents with T1DM (n=81) and T2DM (n=40). The subjects, ages 11–21 years, all had diabetes of >6 months duration. Multivariate linear regression was used to analyze the associations, while comparisons between subgroups were made using two-tailed Student’s t-test.

Results: Vitamin D deficiency (25OHD/mL (37.5 nmol/L) was more prevalent in T2DM patients (47.5%) compared to T1DM patients (18.5%). Subjects with T2DM had significantly elevated transaminases (AST 39.3±2.0 vs. 22.4±1.4, p

Conclusions: The association of elevated ALT with vitamin D deficiency suggests that hepatic dysfunction could impair vitamin D metabolism and negatively impact glycemic control in youth with T2DM.


glycemia, hepatic dysfunction, type 1 diabetes, type 2 diabetes, vitamin D deficiency

DOI of Published Version



Journal of Pediatric Endocrinology and Metabolism. Volume 25, Issue 1-2, Pages 181–186, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/jpem-2011-0403, January 2012.

Journal/Book/Conference Title

Journal of Pediatric Endocrinology and Metabolism


Medical student Zheni Stavre participated in this study as part of the Senior Scholars research program.

A blog post about this research from the Vitamin D Council is available below as an Additional File.

Vitamin D levels and liver disease.pdf (291 kB)
Vitamin D Council blog post 8-30-12 about this work: "Vitamin D levels and liver disease: Type I vs type II diabetes"