Endocrine parameters of cystic fibrosis: back to basics

UMMS Affiliation

Department of Pediatrics; Gene Therapy Center



Document Type


Medical Subject Headings

Aging; Animals; Bone Diseases, Endocrine; Cystic Fibrosis; Diabetes Mellitus; Disease Progression; Female; Humans; Male


Endocrinology, Diabetes, and Metabolism | Pediatrics


Dramatic changes in the life expectancy of cystic fibrosis (CF) patients are occurring, creating a cohort of aging individuals experiencing long-term complications of this chronic disease. The two most common of these complications include CF-related diabetes and CF bone disease. The clinical implications of each have become better understood, as have potential therapies. However, data obtained from the basic science studies of both diseases have not been widely recognized. In this review, we focus on the known and hypothesized pathogenesis of these two disorders. Additionally, the molecular underpinnings of CF will be explained along with the potential interactions with endocrine disease phenotypes.

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Citation: Stalvey, M. and Flotte, T. “Endocrine Parameters of Cystic Fibrosis: Back to Basics.” Journal of Cellular Biochemistry 2009 Oct 1;108(2):353-61. DOI: 10.1002/jcb.22284

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Link to article in PubMed

PubMed ID