Endocrine parameters of cystic fibrosis: back to basics
Department of Pediatrics; Gene Therapy Center
Medical Subject Headings
Aging; Animals; Bone Diseases, Endocrine; Cystic Fibrosis; Diabetes Mellitus; Disease Progression; Female; Humans; Male
Endocrinology, Diabetes, and Metabolism | Pediatrics
Dramatic changes in the life expectancy of cystic fibrosis (CF) patients are occurring, creating a cohort of aging individuals experiencing long-term complications of this chronic disease. The two most common of these complications include CF-related diabetes and CF bone disease. The clinical implications of each have become better understood, as have potential therapies. However, data obtained from the basic science studies of both diseases have not been widely recognized. In this review, we focus on the known and hypothesized pathogenesis of these two disorders. Additionally, the molecular underpinnings of CF will be explained along with the potential interactions with endocrine disease phenotypes.
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Citation: Stalvey, M. and Flotte, T. “Endocrine Parameters of Cystic Fibrosis: Back to Basics.” Journal of Cellular Biochemistry 2009 Oct 1;108(2):353-61. DOI: 10.1002/jcb.22284
Stalvey, Michael S. and Flotte, Terence R., "Endocrine parameters of cystic fibrosis: back to basics" (2009). Endocrinology/Diabetes. 26.