The Department of Pathology at the University of Massachusetts Medical School is committed to excellence in the three areas that comprise its mission: the practice of anatomic and clinical pathology diagnosis and consultation for a large academic medical center and its community affiliates; the advancement of knowledge through basic and clinical research and the translation of advances from the laboratory to clinical practice; the training of medical and graduate students, clinical and research fellows, and pathology residents. This collection showcases the the journal articles, books, book chapters, and other publications and presentations written by faculty and researchers of the Department of Pathology.

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Publications from 1992

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Polyclonality of the cytotoxic T lymphocyte response to virus infection, Sharon R. Nahill and Raymond M. Welsh

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Protein tyrosine kinase activities of the epidermal growth factor receptor and ErbB proteins: correlation of oncogenic activation with altered kinetics, Nandini Nair, Roger J. Davis, and Harriet L. Robinson

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Inhibition of cytotoxic T lymphocyte-induced target cell DNA fragmentation, but not lysis, by inhibitors of DNA topoisomerases I and II, Walter K. Nishioka and Raymond M. Welsh

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Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker, John J. Nunnari, Marc Fisher, and Stanley D. T. White

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5' avian leukosis virus sequences and osteopetrotic potential, Harriet L. Robinson, Rosalinda Gram Foster, Bruce P. Blais, Sigrid S. Reinsch, Michael C. Newstein, and Peter R. Shank

Characterization of an angiosarcoma-inducing mutation in the erbB oncogene, Harriet L. Robinson, Sharon Elizabeth Tracy, Nandini Nair, Cherie A. Taglienti, and Daniel C. Gamett

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Generation of "natural killer cell-escape" variants of Pichinde virus during acute and persistent infections, Mauricio Vargas-Cortes, Carey L. O'Donnell, Joseph Walter Maciaszek, and Raymond M. Welsh

Publications from 1991

Primary progressive aphasia with focal neuronal achromasia, Carol F. Lippa, R. Cohen, Thomas W. Smith, and David A. Drachman

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Value of dual-energy CT in differentiating focal fatty infiltration of the liver from low-density masses, Vassilios D. Raptopoulos, Andrew Karellas, Jeffrey Bernstein, Frank R. Reale, Chris Constantinou, and John K. Zawacki

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Human immunodeficiency virus type 1 NL4-3 replication in four T-cell lines: rate and efficiency of entry, a major determinant of permissiveness, Kishore K. Srivastava, Roberto Fernandez-Larsson, Donna M. Zinkus, and Harriet L. Robinson

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Natural killer (NK) cell response to virus infections in mice with severe combined immunodeficiency. The stimulation of NK cells and the NK cell-dependent control of virus infections occur independently of T and B cell function, Raymond M. Welsh, Jeffery O. Brubaker, Mauricio Vargas-Cortes, and Carey L. O'Donnell

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Lipid deposition and intimal stress and strain. A study in rats with aortic stenosis, Thomas Zand, G. Majno, John J. Nunnari, Allen H. Hoffman, Brian J. Savilonis, Bruce MacWilliams, and Isabelle Joris

Publications from 1990

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Infrequent involvement of c-fos in avian leukosis virus-induced nephroblastoma, K. L. Collart, Rosemarie E. Aurigemma, Ralph E. Smith, Sadaaki Kawai, and Harriet L. Robinson

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Immunopathology of diabetes in the RT6-depleted diabetes-resistant BB/Wor rat, Zhong Jiang, Eugene S. Handler, Aldo A. Rossini, and Bruce A. Woda

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Capillary leakage in inflammation. A study by vascular labeling, Isabelle Joris, Henri F. Cuenoud, Gary V. Doern, Jean. M. Underwood, and G. Majno

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Depletion of RT6.1+ T lymphocytes alone is insufficient to induce diabetes in diabetes-resistant BB/Wor rats, Arthur A. Like

The indusium griseum: is it involved in Alzheimer's disease, Carol F. Lippa, Thomas W. Smith, Umberto DeGirolami, and David A. Drachman

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Delayed treatment with a t-PA analogue and streptokinase in a rabbit embolic stroke model, David A. Phillips, Marc Fisher, Michael A. Davis, Thomas W. Smith, and Roy H.L. Pang

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Accumulation of human immunodeficiency virus type 1 DNA in T cells: results of multiple infection events, Harriet L. Robinson and Donna M. Zinkus

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Mechanism of killing by virus-induced cytotoxic T lymphocytes elicited in vivo, Raymond M. Welsh, Walter K. Nishioka, Rustom Antia, and Patricia L. Dundon

Publications from 1989

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Herpesvirus saimiri strains from three DNA subgroups have different oncogenic potentials in New Zealand white rabbits, Maria M. Medveczky, Eva Szomolanyi-Tsuda, RuthAnn M. Hesselton, David DeGrand, Peter Geck, and Peter G. Medveczky

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Antiviral effect of lymphokine-activated killer cells: chemotaxis and homing to sites of virus infection, Robert J. Natuk, Jack F. Bukowski, Jeffery O. Brubaker, and Raymond M. Welsh

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The effects of a new tissue plasminogen activator analogue, Fb-Fb-CF, on cerebral reperfusion in a rabbit embolic stroke model, David A. Phillips, Marc Fisher, Thomas W. Smith, Michael A. Davis, and Roy H.L. Pang

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Virus-induced polyclonal cytotoxic T lymphocyte stimulation, Hyekyung Yang, Patricia L. Dundon, Sharon R. Nahill, and Raymond M. Welsh

Publications from 1988

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Antiviral effect of lymphokine-activated killer cells: characterization of effector cells mediating prophylaxis, Jack F. Bukowski, Hyekyung Yang, and Raymond M. Welsh

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Pure motor hemiplegia secondary to a saccular basilar artery aneurysm, Marc Fisher, Thomas W. Smith, and Richard Jacobs

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Factors affecting visualization of posterior rib fractures in abused infants, Paul K. Kleinman; Sandy C. Marks, Jr.; Vernard I. Adams; and Brian D. Blackbourne

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Blastogenesis of large granular lymphocytes in nonlymphoid organs, Kim W. McIntyre, Robert J. Natuk, Christine A. Biron, Kenneth Kase, Joel S. Greenberger, and Raymond M. Welsh

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The safety and angiographic efficacy of tissue plasminogen activator in a cerebral embolization model, David A. Phillips, Marc Fisher, Thomas W. Smith, and Michael A. Davis

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Langerhans cell histiocytosis with the radiographic findings of Erdheim-Chester disease, Richard J. Waite, Paul W. Doherty, Marcia K. Liepman, and Bruce A. Woda

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The role of interferon in the regulation of virus infections by cytotoxic lymphocytes, Raymond M. Welsh, Hyekyung Yang, and Jack F. Bukowski

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Identification of T cell subsets and class I and class II antigen expression in islet grafts and pancreatic islets of diabetic BioBreeding/Worcester rats, Elora J. Weringer and Arthur A. Like

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Endothelial adaptations in aortic stenosis. Correlation with flow parameters, Thomas Zand, John J. Nunnari, Allen H. Hoffman, Brian J. Savilonis, Bruce MacWilliams, G. Majno, and Isabelle Joris

Publications from 1987

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Natural killer cells are not required for interferon-mediated prophylaxis against vaccinia or murine cytomegalovirus infections, Jack F. Bukowski, Kim W. McIntyre, Hyekyung Yang, and Raymond M. Welsh

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The importance of carotid artery plaque disruption and hemorrhage, Marc Fisher, Andrew M. Blumenfeld, and Thomas W. Smith

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Cytotoxic Lymphocytes in Viral Hepatitis: a Thesis, Kim W. McIntyre

Vacuolar change in Alzheimer's disease, Thomas W. Smith, Ursula E. Anwer, Umberto DeGirolami, and David A. Drachman

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In vitro immortalization of marmoset cells with three subgroups of herpesvirus saimiri, Eva Szomolanyi-Tsuda, Peter G. Medveczky, and Carel Mulder

Publications from 1986

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Enhanced susceptibility to cytotoxic T lymphocytes of target cells isolated from virus-infected or interferon-treated mice, Jack F. Bukowski and Raymond M. Welsh

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The role of natural killer cells and interferon in resistance to acute infection of mice with herpes simplex virus type 1, Jack F. Bukowski and Raymond M. Welsh

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Accumulation of natural killer and cytotoxic T large granular lymphocytes in the liver during virus infection, Kim W. McIntyre and Raymond M. Welsh

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Inhibition of atherosclerosis by cod-liver oil in a hyperlipidemic swine model, Bonnie H. Weiner, Ira S. Ockene, Peter H. Levine, Henri F. Cuenoud, Marc Fisher, Brian F. Johnson, Assaad S. Daoud, John Jarmolych, David W. Hosmer, and Mark H. Johnson

Publications from 1985

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Adoptive transfer studies demonstrating the antiviral effect of natural killer cells in vivo, Jack F. Bukowski, John F. Warner, Gunther Dennert, and Raymond M. Welsh

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Inability of interferon to protect virus-infected cells against lysis by natural killer (NK) cells correlates with NK cell-mediated antiviral effects in vivo, Jack F. Bukowski and Raymond M. Welsh

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Interferon enhances the susceptibility of virus-infected fibroblasts to cytotoxic T cells, Jack F. Bukowski and Raymond M. Welsh

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Exquisite specificity of adoptive immunization in arenavirus-infected mice, Kim W. McIntyre, Jack F. Bukowski, and Raymond M. Welsh

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Induction of angiosarcoma by a c-erbB transducing virus, Sharon Elizabeth Tracy, Bruce A. Woda, and Harriet L. Robinson

Expression of asialo GM1 and other antigens and glycolipids on natural killer cells and spleen leukocytes in virus-infected mice, Hyekyung Yang, Ganesa Yogeeswaran, Jack F. Bukowski, and Raymond M. Welsh

Publications from 1984

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The Role of Natural Killer Cells and Interferon in Virus Infections: A Thesis, Jack F. Bukowski

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Pathogenesis of murine cytomegalovirus infection in natural killer cell-depleted mice, Jack F. Bukowski, Bruce A. Woda, and Raymond M. Welsh

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Role of natural killer cells in virus infections of mice, Raymond M. Welsh, Christine A. Biron, Jack F. Bukowski, Kim W. McIntyre, and Hyekyung Yang

Publications from 1983

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Elevated natural killer cell-mediated cytotoxicity, plasma interferon, and tumor cell rejection in mice persistently infected with lymphocytic choriomeningitis virus, Jack F. Bukowski, Christine A. Biron, and Raymond M. Welsh

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Natural killer cell depletion enhances virus synthesis and virus-induced hepatitis in vivo, Jack F. Bukowski, Bruce A. Woda, Sonoku Habu, Ko Okumura, and Raymond M. Welsh

Publications from 1981

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Intramedullary spinal cord metastasis, Peter R. Sebastian, Marc Fisher, Thomas W. Smith, and Robin I. Davidson

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Differences in synthesis of membrane proteins by leukemic cells from spleen and peripheral blood indicate distinct subsets of malignant cells in a patient with prolymphocytic leukemia, Robert Christopher Spiro, Jack E. Ansell, Isao Katayama, Kamala Muralidharan, John L. Sullivan, and Robert E. Humphreys

Publications from 1980

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Subsets of hairy cell leukemia defined by unique membrane proteins, Robert Christopher Spiro, Motohiko Aiba, Isao Katayama, Philip P. Raffa, Kiyoshi Sakamoto, David T. Purtilo, John L. Sullivan, and Robert E. Humphreys