The Department of Pathology at the University of Massachusetts Medical School is committed to excellence in the three areas that comprise its mission: the practice of anatomic and clinical pathology diagnosis and consultation for a large academic medical center and its community affiliates; the advancement of knowledge through basic and clinical research and the translation of advances from the laboratory to clinical practice; the training of medical and graduate students, clinical and research fellows, and pathology residents. This collection showcases the the journal articles, books, book chapters, and other publications and presentations written by faculty and researchers of the Department of Pathology.

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Publications from 1999

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DNA vaccines: vector design, delivery, and antigen presentation, David Marc Feltquate

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Effect of CpG methylation on isotype and magnitude of antibody responses to influenza hemagglutinin-expressing plasmid, David Marc Feltquate and Harriet L. Robinson

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A monoclonal antibody reactive with a 40-kDa molecule on fetal thymocytes and tumor cells blocks proliferation and stimulates aggregation and apoptosis, Dancella M. Fernandes, Allison Michelle Baird, Leslie J. Berg, and Kenneth L. Rock

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Diabetes prone BB rats are severely deficient in natural killer T cells, Neal N. Iwakoshi, Dale L. Greiner, Aldo A. Rossini, and John P. Mordes

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Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent manner, Neal N. Iwakoshi, John P. Mordes, Thomas G. Markees, Nancy E. Phillips, Aldo A. Rossini, and Dale L. Greiner

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NOD mice have a generalized defect in their response to transplantation tolerance induction, Thomas G. Markees, David V. Serreze, Nancy E. Phillips, Christopher H. Sorli, Ethel J. Gordon, Leonard D. Shultz, Randolph J. Noelle, Bruce A. Woda, Dale L. Greiner, John P. Mordes, and Aldo A. Rossini

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Distinct proteolytic processes generate the C and N termini of MHC class I-binding peptides, Annie X. Y. Mo, Paolo Cascio, Kristen Lemerise, Alfred L. Goldberg, and Kenneth L. Rock

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Studies on antibody responses following neonatal immunization with influenza hemagglutinin DNA or protein, Tamera Marie Pertmer and Harriet L. Robinson

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Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesis, Igor B. Rosenwald, Jane-Jane Chen, Songtao Wang, Louis Savas, Irving M. London, and James M. Pullman

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The role of LY49 NK cell subsets in the regulation of murine cytomegalovirus infections, Chin Hun Tay, Lawrence Y. Y. Yu, Vinay Kumar, Llewelyn H. Mason, John R. Ortaldo, and Raymond M. Welsh

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The Jak family tyrosine kinase Jak3 is required for IL-2 synthesis by naive/resting CD4+ T cells, Daniel C. Thomis, Jose Aramburu, and Leslie J. Berg

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The Virus-Specific CD4+ T Cell Response During Acute Lymphocytic Choriomeningitis Virus Infection and into Long Term Memory: a Dissertation, Steven Michael Varga

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Expression of the eukaryotic translation initiation factors 4E and 2alpha in non-Hodgkin's lymphomas, Songtao Wang, Igor B. Rosenwald, Michael J. Hutzler, German A. Pihan, Louis Savas, Jane-Jane Chen, and Bruce A. Woda

Publications from 1998

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T cell development and activation in Jak3-deficient mice, Allison Michelle Baird, Daniel C. Thomis, and Leslie J. Berg

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Transbronchial lung biopsy: can specimen quality be predicted at the time of biopsy, Frederick J. Curley, Jasbir S. Johal, Maura E. Burke, and Armando E. Fraire

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Partial liquid ventilation with perfluorocarbon in the treatment of rats with lethal pneumococcal pneumonia, Eric W. Dickson, Stephen O. Heard, Benson Chu, Armando E. Fraire, Angela B. Brueggemann, and Gary V. Doern

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CD57 (Leu-7) expression is helpful in diagnosis of the follicular variant of papillary thyroid carcinoma, Ashraf Khan, Stephen P. Baker, Nilima A. Patwardhan, and James M. Pullman

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Rat estrogen receptor-alpha and -beta, and progesterone receptor mRNA expression in various prostatic lobes and microdissected normal and dysplastic epithelial tissues of the Noble rats, Kin-Mang Lau, Irwin Leav, and Shuk-Mei Ho

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Stability and diversity of T cell receptor repertoire usage during lymphocytic choriomeningitis virus infection of mice, Meei-Yun Lin and Raymond M. Welsh

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Apoptotic regulation of T cells and absence of immune deficiency in virus-infected gamma interferon receptor knockout mice, Barbara L. Lohman and Raymond M. Welsh

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Chronic inflammation: links with angiogenesis and wound healing, G. Majno

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Centrosome defects and genetic instability in malignant tumors, G A Pihan, A Purohit, J Wallace, H Knecht, Bruce A. Woda, Peter J. Quesenberry, and Stephen J. Doxsey

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Protective heterologous antiviral immunity and enhanced immunopathogenesis mediated by memory T cell populations, Liisa K. Selin, Steven Michael Varga, Iris C. Wong, and Raymond M. Welsh

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The role of B7-1 and B7-2 costimulation for the generation of CTL responses in vivo, Luis J. Sigal, Hans Reiser, and Kenneth L. Rock

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T-Cell-independent immunoglobulin G responses in vivo are elicited by live-virus infection but not by immunization with viral proteins or virus-like particles, Eva Szomolanyi-Tsuda, Quang P. Le, Robert L. Garcea, and Raymond M. Welsh

Control of infections by NK cells, Chin Hun Tay, Eva Szomolanyi-Tsuda, and Raymond M. Welsh

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Detection of a high frequency of virus-specific CD4+ T cells during acute infection with lymphocytic choriomeningitis virus, Steven Michael Varga and Raymond M. Welsh

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Stability of virus-specific CD4+ T cell frequencies from acute infection into long term memory, Steven Michael Varga and Raymond M. Welsh

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Alpha beta and gamma delta T-cell networks and their roles in natural resistance to viral infections, Raymond M. Welsh, Meei Y. Lin, Barbara L. Lohman, Steven Michael Varga, Christopher C. Zarozinski, and Liisa K. Selin

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Evaluation of the Galalpha1-3Gal epitope as a host modification factor eliciting natural humoral immunity to enveloped viruses, Raymond M. Welsh, Carey L. O'Donnell, Deborah J. Reed, and Russell P. Rother

Publications from 1997

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Inflammatory markers in chronic hepatitis C, Barbara F. Banner, Carol Allan, Louis Savas, Stephen P. Baker, Graham F. Barnard, and Herbert L. Bonkovsky

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Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization, David Marc Feltquate, Shaun Heaney, Robert G. Webster, and Harriet L. Robinson

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Effect of erionite on the pleural mesothelium of the Fischer 344 rat, Armando E. Fraire, S. Donald Greenberg, Harlan J. Spjut, Ronald F. Dodson, Glenn Williams, Ella Lach-Pasko, and Victor L. Roggli

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The T cell marker RT6 in a rat model of autoimmune diabetes, Dale L. Greiner, Samir Malkani, Toshihiro Kanaitsuka, Rita Bortell, John Doukas, Mark R. Rigby, Barbara J. Whalen, Linda A. Stevens, Joel Moss, John P. Mordes, and Aldo A. Rossini

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Frequency and distribution of DNA fragmentation as a marker of cell death in chronic liver diseases, Zhong Jiang, Yu Liu, Louis Savas, Lynda Smith, Herbert L. Bonkovsky, Stephen P. Baker, and Barbara F. Banner

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HIV-1 Env glycoproteins from two series of primary isolates: replication phenotype and immunogenicity, Farah Mustafa, Joan F. L. Richmond, Roberto Fernandez-Larsson, Shan Lu, Robert Fredriksson, Eva Maria Fenyo, Maryellen O'Connell, Eric Johnson, Jiayu Weng, Joseph C. Santoro, and Harriet L. Robinson

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Necrotizing tracheobronchitis with progressive airflow obstruction associated with paraneoplastic pemphigus, James P. Osmanski II, Armando E. Fraire, and Oren P. Schaefer

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Screening of HIV-1 Env glycoproteins for the ability to raise neutralizing antibody using DNA immunization and recombinant vaccinia virus boosting, Joan F. L. Richmond, Farah Mustafa, Shan Lu, Joseph C. Santoro, Jiayu Weng, Maryellen O'Connell, Eva Maria Fenyo, Julia L. Hurwitz, David C. Montefiori, and Harriet L. Robinson

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DNA immunization for influenza virus: studies using hemagglutinin- and nucleoprotein-expressing DNAs, Harriet L. Robinson, Christine Margaret Boyle, David Marc Feltquate, Merribeth J. Morin, Joseph C. Santoro, and Robert G. Webster

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DNA vaccines, Harriet L. Robinson and Celia Aurora Tiglao Torres

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In Vivo Regulation of Murine Cytomegalovirus Infections: The Role of Cell Surface Molecules and Mechanisms of Control by Natural Killer Cells: A Dissertation, Chin Hun Tay

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Distinct organ-dependent mechanisms for the control of murine cytomegalovirus infection by natural killer cells, Chin Hun Tay and Raymond M. Welsh

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Differential dependence on target site tissue for gene gun and intramuscular DNA immunizations, Celia Aurora Tiglao Torres, Akiko Iwasaki, Brian H. Barber, and Harriet L. Robinson

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Early studies on DNA-based immunizations for measles virus, Hyekyung Yang, Farah Mustafa, Alexandra Valsamakis, Joseph C. Santoro, Diane E. Griffin, and Harriet L. Robinson

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Minimal bystander activation of CD8 T cells during the virus-induced polyclonal T cell response, Christopher C. Zarozinski and Raymond M. Welsh

Publications from 1996

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Analysis of low zone tolerance induction in normal and B cell-deficient mice, Allison Michelle Baird and David C. Parker

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Deletion variants within the NF-kappa B activation domain of the LMP1 oncogene prevail in acquired immunodeficiency syndrome-related large cell lymphomas and human immunodeficiency virus-negative atypical lymphoproliferations, Hans Knecht, Martine Raphael, Cathy McQuain, Sylvia Rothenberger, German A. Pihan, Sophie Camilleri-Broët, Edith Bachmann, Glenn R. Kershaw, Shannon Ryan, Ellen L. W. Kittler, Peter J. Quesenberry, Daniel Schlaifer, Bruce A. Woda, and Pierre Brousset

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T-lymphocyte downregulation after acute viral infection is not dependent on CD95 (Fas) receptor-ligand interactions, Barbara L. Lohman, Enal Shahid Razvi, and Raymond M. Welsh

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Simian immunodeficiency virus DNA vaccine trial in macaques, Shan Lu, James Arthos, David C. Montefiori, Yasuhiro Yasutomi, Kelledy Manson, Farah Mustafa, Eric Johnson, Joseph C. Santoro, J. Wissink, James I. Mullins, Joel R. Haynes, Norman L. Letvin, Michael Wyand, and Harriet L. Robinson

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Metastatic papillary thyroid carcinoma to lung diagnosed by bronchoalveolar lavage, Curtis J. Mello, Irini E. Veronikis, Armando E. Fraire, Neil Aronin, Richard S. Irwin, and Lewis E. Braverman

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DNA vaccines, Harriet L. Robinson, Shan Lu, David Marc Feltquate, Celia Aurora Tiglao Torres, Joann M. Richmond, Christine Margaret Boyle, Merribeth J. Morin, Joseph C. Santoro, Robert G. Webster, David C. Montefiori, Yasuhiro Yasutomi, Norman L. Letvin, Kelledy Manson, Michael Wyand, and Joel R. Haynes

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Reduction of otherwise remarkably stable virus-specific cytotoxic T lymphocyte memory by heterologous viral infections, Liisa K. Selin, Kristin Vergilis, Raymond M. Welsh, and Sharon R. Nahill

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T cell-independent antibody-mediated clearance of polyoma virus in T cell-deficient mice, Eva Szomolanyi-Tsuda and Raymond M. Welsh

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The CD45RB-associated epitope defined by monoclonal antibody CZ-1 is an activation and memory marker for mouse CD4 T cells, Steven Michael Varga and Raymond M. Welsh

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Simian immunodeficiency virus-specific cytotoxic T-lymphocyte induction through DNA vaccination of rhesus monkeys, Yasuhiro Yasutomi, Harriet L. Robinson, Shan Lu, Farah Mustafa, Christine Lekutis, James Arthos, James I. Mullins, Gerald Voss, Kelledy Manson, Michael Wyand, and Norman L. Letvin

Publications from 1995

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Genetics of the BB rat: association of autoimmune disorders (diabetes, insulitis, and thyroiditis) with lymphopenia and major histocompatibility complex class II, Takuya Awata, Dennis L. Guberski, and Arthur A. Like

A detailed analysis of the Knodell score and other histologic parameters as predictors of response to interferon therapy in chronic hepatitis C, Barbara F. Banner, Ann L. Barton, Edward Earl Cable, Lynda Smith, and Herbert L. Bonkovsky

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Distribution of iron in the liver predicts the response of chronic hepatitis C infection to interferon therapy, Ann L. Barton, Barbara F. Banner, Edward Earl Cable, and Herbert L. Bonkovsky

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Major histocompatibility complex class I antigens and the control of viral infections by natural killer cells, Randy R. Brutkiewicz and Raymond M. Welsh

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A major histocompatibility complex class II restriction for BioBreeding/Worcester diabetes-inducing T cells, Karen E. Ellerman and Arthur A. Like

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Apoptosis, oncosis, and necrosis. An overview of cell death, G. Majno and Isabelle Joris

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Lymphocyte apoptosis during the silencing of the immune response to acute viral infections in normal, lpr, and Bcl-2-transgenic mice, Enal Shahid Razvi, Zhong Jiang, Bruce A. Woda, and Raymond M. Welsh

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Apoptosis in viral infections, Enal Shahid Razvi and Raymond M. Welsh

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In vivo state of antiviral CTL precursors. Characterization of a cycling cell population containing CTL precursors in immune mice, Enal Shahid Razvi, Raymond M. Welsh, and Hugh I. McFarland

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NK cell response to viral infections in beta 2-microglobulin-deficient mice, Chin Hun Tay, Raymond M. Welsh, and Randy R. Brutkiewicz

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Role of apoptosis in the regulation of virus-induced T cell responses, immune suppression, and memory, Raymond M. Welsh, Liisa K. Selin, and Enal Shahid Razvi

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Protective CTL-dependent immunity and enhanced immunopathology in mice immunized by particle bombardment with DNA encoding an internal virion protein, Christopher C. Zarozinski, Ellen F. Fynan, Liisa K. Selin, Harriet L. Robinson, and Raymond M. Welsh

Publications from 1994

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Reversible endothelial cell relaxation induced by oxygen and glucose deprivation. A model of ischemia in vitro, John Doukas, Anne H. Cutler, Carl A. Boswell, Isabelle Joris, and G. Majno

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Polyinosinic:polycytidylic acid is a potent activator of endothelial cells, John Doukas, Anne H. Cutler, and John P. Mordes

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Thymic epithelial defects and predisposition to autoimmune disease in BB rats, John Doukas, John P. Mordes, Christine Swymer, Dena Niedzwiecki, Rebecca Mason, Jan Rozing, Aldo A. Rossini, and Dale L. Greiner

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Effect of fibrous glass on rat pleural mesothelium. Histopathologic observations, Armando E. Fraire, S. Donald Greenberg, Harlan J. Spjut, Victor L. Roggli, Ronald F. Dodson, Joiner Cartwright, Glenn Williams, and Stephen P. Baker

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Susceptibility to cytotoxic T lymphocyte-induced apoptosis is a function of the proliferative status of the target, Walter K. Nishioka and Raymond M. Welsh

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Cross-reactivities in memory cytotoxic T lymphocyte recognition of heterologous viruses, Liisa K. Selin, Sharon R. Nahill, and Raymond M. Welsh

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Acute, lethal, natural killer cell-resistant myeloproliferative disease induced by polyomavirus in severe combined immunodeficient mice, Eva Szomolanyi-Tsuda, Patricia L. Dundon, Isabelle Joris, Leonard D. Shultz, Bruce A. Woda, and R M Welsh

Publications from 1993

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Characterization of the inflammatory cell populations in normal colon and colonic carcinomas, Barbara F. Banner, Louis Savas, Stephen P. Baker, and Bruce A. Woda

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Infection of peripancreatic lymph nodes but not islets precedes Kilham rat virus-induced diabetes in BB/Wor rats, David W. Brown, Raymond M. Welsh, and Arthur A. Like

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Analysis of and Role for Effector and Target Cell Structures in the Regulation of Virus Infections by Natural Killer Cells: a Dissertation, Randy R. Brutkiewicz

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The monoclonal antibody CZ-1 identifies a mouse CD45-associated epitope expressed on interleukin-2-responsive cells, Randy R. Brutkiewicz, Carey L. O'Donnell, Joseph Walter Maciaszek, Raymond M. Welsh, and Mauricio Vargas-Cortes

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Virus-Host Interactions in the Development of Avian Leukosis Virus-Induced Osteopetrosis: a Dissertation, Rosalinda Gram Foster

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DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations, Ellen F. Fynan, Robert G. Webster, D H Fuller, Joel R. Haynes, Joseph C. Santoro, and Harriet L. Robinson

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Effects of virally expressed interleukin-10 on vaccinia virus infection in mice, Michael G. Kurilla, Sankar Swaminathan, Raymond M. Welsh, Elliott D. Kieff, and Randy R. Brutkiewicz

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Vascular amyloid deposition in Alzheimer's disease. Neither necessary nor sufficient for the local formation of plaques or tangles, Carol F. Lippa, James E. Hamos, Thomas W. Smith, Donna Pulaski-Salo, and David A. Drachman

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HIV-1 Sequences in the Establishment of Chronic Virus Producers: a Thesis, Farah Mustafa

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High frequency of cross-reactive cytotoxic T lymphocytes elicited during the virus-induced polyclonal cytotoxic T lymphocyte response, Sharon R. Nahill and Raymond M. Welsh

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Programmed cell death of T lymphocytes during acute viral infection: a mechanism for virus-induced immune deficiency, Enal Shahid Razvi and Raymond M. Welsh

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High stimulatory activity of dendritic cells from diabetes-prone BioBreeding/Worcester rats exposed to macrophage-derived factors, Anna Tafuri, William E. Bowers, Eugene S. Handler, Michael C. Appel, Robert A. Lew, Dale L. Greiner, John P. Mordes, and Aldo A. Rossini

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Induction of renal adenocarcinoma by a nonmutated erbB oncogene, Cherie A. Taglienti, Barbara F. Banner, Roger J. Davis, and Harriet L. Robinson

Publications from 1992

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Anti-CD2 monoclonal antibodies prevent spontaneous and adoptive transfer of diabetes in the BB/Wor rat, Avlin K. Barlow and Arthur A. Like

Window of vulnerability of vaccinia virus-infected cells to natural killer (NK) cell-mediated cytolysis correlates with enhanced NK cell triggering and is concomitant with a decrease in H-2 class I antigen expression, Randy R. Brutkiewicz, Stephen J. Klaus, and Raymond M. Welsh

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Replication of patient isolates of human immunodeficiency virus type 1 in T cells: a spectrum of rates and efficiencies of entry, Roberto Fernandez-Larsson, Kishore K. Srivastava, Shan Lu, and Harriet L. Robinson

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Intracranial metastatic adenoid cystic carcinoma: presumed hematogenous spread from a primary tumor in the parotid gland, Nicholas D. Gelber, Ronald L. Ragland, John R. Knorr, Thomas W. Smith, and Bernard B. Stone

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Human immunodeficiency virus type 1 entry into T cells: more-rapid escape from an anti-V3 loop than from an antireceptor antibody, Shan Lu, Scott D. Putney, and Harriet L. Robinson

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CD11b (Mac-1): a marker for CD8+ cytotoxic T cell activation and memory in virus infection, Hugh I. McFarland, Sharon R. Nahill, Joseph Walter Maciaszek, and Raymond M. Welsh

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Polyclonality of the cytotoxic T lymphocyte response to virus infection, Sharon R. Nahill and Raymond M. Welsh

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Protein tyrosine kinase activities of the epidermal growth factor receptor and ErbB proteins: correlation of oncogenic activation with altered kinetics, Nandini Nair, Roger J. Davis, and Harriet L. Robinson

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Inhibition of cytotoxic T lymphocyte-induced target cell DNA fragmentation, but not lysis, by inhibitors of DNA topoisomerases I and II, Walter K. Nishioka and Raymond M. Welsh

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Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker, John J. Nunnari, Marc Fisher, and Stanley D. T. White

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5' avian leukosis virus sequences and osteopetrotic potential, Harriet L. Robinson, Rosalinda Gram Foster, Bruce P. Blais, Sigrid S. Reinsch, Michael C. Newstein, and Peter R. Shank

Characterization of an angiosarcoma-inducing mutation in the erbB oncogene, Harriet L. Robinson, Sharon Elizabeth Tracy, Nandini Nair, Cherie A. Taglienti, and Daniel C. Gamett

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Generation of "natural killer cell-escape" variants of Pichinde virus during acute and persistent infections, Mauricio Vargas-Cortes, Carey L. O'Donnell, Joseph Walter Maciaszek, and Raymond M. Welsh