The Department of Pathology at the University of Massachusetts Medical School is committed to excellence in the three areas that comprise its mission: the practice of anatomic and clinical pathology diagnosis and consultation for a large academic medical center and its community affiliates; the advancement of knowledge through basic and clinical research and the translation of advances from the laboratory to clinical practice; the training of medical and graduate students, clinical and research fellows, and pathology residents. This collection showcases the the journal articles, books, book chapters, and other publications and presentations written by faculty and researchers of the Department of Pathology.

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Publications from 2005

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Cholangitis: a histologic classification based on patterns of injury in liver biopsies, Yanhua Li, Gamze Ayata, Stephen P. Baker, and Barbara F. Banner

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The Role of Itk in T Cell Development: A Dissertation, Julie Ann Lucas

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Both dendritic cells and macrophages can stimulate naive CD8 T cells in vivo to proliferate, develop effector function, and differentiate into memory cells, Lu-Ann M. Pozzi, Joseph Walter Maciaszek, and Kenneth L. Rock

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Leucine aminopeptidase is not essential for trimming peptides in the cytosol or generating epitopes for MHC class I antigen presentation, Charles Fenton Towne, Ian A. York, Joost J. Neijssen, Margaret L. Karow, Andrew J. Murphy, David M. Valenzuela, George D. Yancopoulos, Jacques J. Neefjes, and Kenneth L. Rock

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Facile, comprehensive, high-throughput genotyping of human genital papillomaviruses using spectrally addressable liquid bead microarrays, Jan Wallace, Bruce A. Woda, and German A. Pihan

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A mutant cell with a novel defect in MHC class I quality control, Ian A. York, Ethan P. Grant, A. Maria Dahl, and Kenneth L. Rock

Publications from 2004

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The Role of ITK and RLK in CD8+ T Cell Development and Function: a Dissertation, Luana O. Atherly

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Mammaglobin and CRxA-01 in pleural effusion cytology: potential utility of distinguishing metastatic breast carcinomas from other cytokeratin 7-positive/cytokeratin 20-negative carcinomas, Armando Ciampa, Gary R. Fanger, Ashraf Khan, Kenneth L. Rock, and Bo Xu

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Mycoplasma infection induces a scleroderma-like centrosome autoantibody response in mice, Irina Catrinel Gavanescu, German A. Pihan, Ensar Halilovic, Eva Szomolanyi-Tsuda, Raymond M. Welsh, and Stephen J. Doxsey

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Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice, Ethel J. Gordon, Linda S. Wicker, Laurence B. Peterson, David V. Serreze, Thomas G. Markees, Leonard D. Shultz, Aldo A. Rossini, Dale L. Greiner, and John P. Mordes

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The Role of γс Cytokines in T Cell Development, T Cell Homeostasis and CD8+ T Cell Function: A Dissertation, Sara Gozalo

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Inducible changes in cell size and attachment area due to expression of a mutant SWI/SNF chromatin remodeling enzyme, David A. Hill, Simion I. Chiosea, Saha Jamaluddin, Kanaklata Roy, Andrew H. Fischer, Douglas D. Boyd, Jeffrey A. Nickerson, and Anthony N. Imbalzano

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P504S immunostaining boosts diagnostic resolution of "suspicious" foci in prostatic needle biopsy specimens, Zhong Jiang, Kenneth A. Iczkowski, Bruce A. Woda, Maria S. Tretiakova, and Ximing J. Yang

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Discovery and clinical application of a novel prostate cancer marker: alpha-methylacyl CoA racemase (P504S), Zhong Jiang, Bruce A. Woda, Chin-Lee Wu, and Ximing J. Yang

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STAT5 is required for thymopoiesis in a development stage-specific manner, Joonsoo Kang, Brian DiBenedetto, Kavitha Narayan, Hang Zhao, Sandy D. Der, and Cynthia A. Chambers

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Comprehensive early and lasting loss of memory CD8 T cells and functional memory during acute and persistent viral infections, Sung-Kwon Kim and Raymond M. Welsh

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Extraarticular synovial chondromatosis: review of epidemiology, imaging studies, microscopy and pathogenesis, with a report of an additional case in a child, Emily Ko, Errol Mortimer, and Armando E. Fraire

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The role of Janus Kinase 3 in CD4+ T Cell Homeostasis and Function: A Dissertation, Shane Renee Mayack

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Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet, Andrew Todd Miller, Heather M. Wilcox, Zhongbin Lai, and Leslie J. Berg

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Origin and fate of lymphocytic choriomeningitis virus-specific CD8+ T cells coexpressing the inhibitory NK cell receptor Ly49G2, Craig D. Peacock and Raymond M. Welsh

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Macrophages Directly Prime Naïve CD8+ T Cells: a Dissertation, Lu-Ann M. Pozzi

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Cellular protein is the source of cross-priming antigen in vivo, Lianjun Shen and Kenneth L. Rock

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Enhanced catalytic action of HLA-DM on the exchange of peptides lacking backbone hydrogen bonds between their N-terminal region and the MHC class II alpha-chain, Efstratios Stratikos, Don C. Wiley, and Lawrence J. Stern

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Judging a virus by its cover, Eva Szomolanyi-Tsuda and Raymond M. Welsh

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Preapoptotic phenotype of viral epitope-specific CD8 T cells precludes memory development and is an intrinsic property of the epitope, Xiaoting Z. Wang, Michael A. Brehm, and Raymond M. Welsh

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Apoptosis and loss of virus-specific CD8+ T-cell memory, Raymond M. Welsh, Kapil Bahl, and Xiaoting Z. Wang

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Multiple gastrointestinal stromal tumors in type I neurofibromatosis: a pathologic and molecular study, Rhonda K. Yantiss, Andrew E. Rosenberg, Lisa Sarran, Peter Besmer, and Cristina R. Antonescu

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Dynamic regulation of estrogen receptor-beta expression by DNA methylation during prostate cancer development and metastasis, Xuegong Zhu, Irwin Leav, Yuet-Kin Leung, Mengchu Wu, Qin Liu, Ying Gao, John E. McNeal, and Shuk-Mei Ho

Publications from 2003

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The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes, Kishore R. Alugupalli, Rachel M. Gerstein, Jianzhu Chen, Eva Szomolanyi-Tsuda, Robert T. Woodland, and John M. Leong

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Spirochete-platelet attachment and thrombocytopenia in murine relapsing fever borreliosis, Kishore R. Alugupalli, Alan D. Michelson, Isabelle Joris, Tom G. Schwan, Kairbaan Hodivala-Dilke, Richard O. Hynes, and John M. Leong

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Direct visualization of cross-reactive effector and memory allo-specific CD8 T cells generated in response to viral infections, Michael A. Brehm, Thomas G. Markees, Keith A. Daniels, Dale L. Greiner, Aldo A. Rossini, and Raymond M. Welsh

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Specific history of heterologous virus infections determines anti-viral immunity and immunopathology in the lung, Hong D. Chen, Armando E. Fraire, Isabelle Joris, Raymond M. Welsh, and Liisa K. Selin

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Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue, Huiling Liang, Qin Chen, Andrew H. Coles, Stephen J. Anderson, German A. Pihan, Allan Bradley, Rachel M. Gerstein, Roland Jurecic, and Stephen N. Jones

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The role of Tec family kinases in T cell development and function, Julie Ann Lucas, Andrew Todd Miller, Luana O. Atherly, and Leslie J. Berg

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The Function of the Tyrosine Kinase, Itk, in CD4+ T Cell Differentiation and Death: a Dissertation, Andrew Todd Miller

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Branched fatty acids in dairy and beef products markedly enhance alpha-methylacyl-CoA racemase expression in prostate cancer cells in vitro, James A. Mobley, Irwin Leav, Patrick J. Zielie, Chad Wotkowitz, James E. Evans, Ying-Wai Lam, Byung Suk L'Esperance, Zhong Jiang, and Shuk-Mei Ho

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A fractal clonotype distribution in the CD8+ memory T cell repertoire could optimize potential for immune responses, Yuri N. Naumov, Elena N. Naumova, Kevin T. Hogan, Liisa K. Selin, and Jack Gorski

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Estrogen receptor-beta expression in human testicular germ cell tumors, Vernon M. Pais, Irwin Leav, Kin-Mang Lau, Zhong Jiang, and Shuk-Mei Ho

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Attrition of virus-specific memory CD8+ T cells during reconstitution of lymphopenic environments, Craig D. Peacock, Sung-Kwon Kim, and Raymond M. Welsh

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Centrosome abnormalities and chromosome instability occur together in pre-invasive carcinomas, German A. Pihan, Jan Wallace, Yening Zhou, and Stephen J. Doxsey

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MHC Class I Antigen Presentation is Regulated by the SUMO-Conjugating Enzyme UBC9: a Dissertation, Yuelei Shen

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An alternative splice form of Mdm2 induces p53-independent cell growth and tumorigenesis, Heather Anne Steinman, Ezra Burstein, Christopher J. Lengner, Joseph R. Gosselin, German A. Pihan, Colin S. Duckett, and Stephen N. Jones

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Virus-specific CD8 T cells in peripheral tissues are more resistant to apoptosis than those in lymphoid organs, Xiaoting Z. Wang, Susan E. Stepp, Michael A. Brehm, Hong D. Chen, Liisa K. Selin, and Raymond M. Welsh

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The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation, Ian A. York, Annie X. Y. Mo, Kristen Lemerise, Wanyong Zeng, Yuelei Shen, Carmela R. Abraham, Tomo Saric, Alfred L. Goldberg, and Kenneth L. Rock

Publications from 2002

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Expression of estrogen receptor beta in the fetal, neonatal, and prepubertal human prostate, Jason Y. Adams, Irwin Leav, Kin-Mang Lau, Shuk-Mei Ho, and Solveig M.V. Pflueger

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Increased production of interleukin-8 in primary human monocytes and in human epithelial and endothelial cell lines after dengue virus challenge, Irene Bosch, Kris Xhaja, Luis Estevez, Gregory Raines, Heather J. Melichar, Rajas V. Warke, Marcia V. Fournier, Francis A. Ennis, and Alan L. Rothman

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The lymphoproliferative defect in CTLA-4-deficient mice is ameliorated by an inhibitory NK cell receptor, Cynthia A. Chambers, Joonsoo Kang, Yongjian Wu, Werner Held, David H. Raulet, and James P. Allison

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Activation and Role of Memory CD8 T Cells in Heterologous Antiviral Immunity and Immunopathology in the Lung: A Dissertation, Hong Chen

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Viral abrogation of stem cell transplantation tolerance causes graft rejection and host death by different mechanisms, Daron Forman, Raymond M. Welsh, Thomas G. Markees, Bruce A. Woda, John P. Mordes, Aldo A. Rossini, and Dale L. Greiner

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Dynamics of memory T cell proliferation under conditions of heterologous immunity and bystander stimulation, Sung-Kwon Kim, Michael A. Brehm, Raymond M. Welsh, and Liisa K. Selin

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The absence of Itk inhibits positive selection without changing lineage commitment, Julie Ann Lucas, Luana O. Atherly, and Leslie J. Berg

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Defective Fas ligand expression and activation-induced cell death in the absence of IL-2-inducible T cell kinase, Andrew Todd Miller and Leslie J. Berg

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New insights into the regulation and functions of Tec family tyrosine kinases in the immune system, Andrew Todd Miller and Leslie J. Berg

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The iddm4 locus segregates with diabetes susceptibility in congenic WF.iddm4 rats, John P. Mordes, Jean H. Leif, Stephen Novak, Cheryl DeScipio, Dale L. Greiner, and Elizabeth P. Blankenhorn

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Gene expression profiling of testosterone and estradiol-17 beta-induced prostatic dysplasia in Noble rats and response to the antiestrogen ICI 182,780, Christopher J. Thompson, Neville N. C. Tam, Jennifer M. Joyce, Irwin Leav, and Shuk-Mei Ho

Publications from 2001

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Ubiquitin as a marker of cell injury in nonalcoholic steatohepatitis, Barbara F. Banner, Louis Savas, Jaroslav Zivny, Kristina D. Tortorelli, and Herbert L. Bonkovsky

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Increased expression of the interleukin-11 receptor and evidence of STAT3 activation in prostate carcinoma, Cara L. Campbell, Zhong Jiang, Diane M. F. Savarese, and Todd M. Savarese

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Memory CD8+ T cells in heterologous antiviral immunity and immunopathology in the lung, Hong D. Chen, Armando E. Fraire, Isabelle Joris, Michael A. Brehm, Raymond M. Welsh, and Liisa K. Selin

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Murine cytomegalovirus is regulated by a discrete subset of natural killer cells reactive with monoclonal antibody to Ly49H, Keith A. Daniels, Gene A. Devora, Wayne C. Lai, Carey L. O'Donnell, Michael Bennett, and Raymond M. Welsh

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Cutting edge: two distinct mechanisms lead to impaired T cell homeostasis in Janus kinase 3- and CTLA-4-deficient mice, Sara Gozalo, James M. McNally, Meei-Yun Lin, Cynthia A. Chambers, and Leslie J. Berg

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Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in mice, Cynthia J. Guidi, Arthur T. Sands, Brian P. Zambrowicz, Tod K. Turner, Delia A. Demers, William Webster, Thomas W. Smith, Anthony N. Imbalzano, and Stephen N. Jones

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Anti-peptide antibody blocks peptide binding to MHC class I molecules in the endoplasmic reticulum, Craig J. Hilton, A. Maria Dahl, and Kenneth L. Rock

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Skin allograft maintenance in a new synchimeric model system of tolerance, Neal N. Iwakoshi, Thomas G. Markees, Nicole A. Turgeon, Thomas B. Thornley, Amy Cuthbert, Jean Leif, Nancy E. Phillips, John P. Mordes, Dale L. Greiner, and Aldo A. Rossini

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Absence of hippocampal sclerosis in children with multiple daily seizures since infancy, Sanjeev V. Kothare, Ana Sotrel, Michael Duchowny, Prasanna Jayakar, Paul C. Marshall, and Thomas W. Smith

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Comparative studies of the estrogen receptors beta and alpha and the androgen receptor in normal human prostate glands, dysplasia, and in primary and metastatic carcinoma, Irwin Leav, Kin-Mang Lau, Jason Y. Adams, John E. McNeal, Mary-Ellen Taplin, Jianfu Wang, Hema Singh, and Shuk-Mei Ho

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Attrition of bystander CD8 T cells during virus-induced T-cell and interferon responses, James M. McNally, Christopher C. Zarozinski, Meei Y. Lin, Michael A. Brehm, Hong D. Chen, and Raymond M. Welsh

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Towards the reconstruction of central nervous system white matter using neural precursor cells, Masato Mitome, Hoi Pang Low, Anthony van den Pol, John J. Nunnari, Merrill K. Wolf, Susan Billings-Gagliardi, and William J. Schwartz

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Sequences that flank subdominant and cryptic epitopes influence the proteolytic generation of MHC class I-presented peptides, Annie X. Y. Mo, Steven F. L. van Lelyveld, Abie Craiu, and Kenneth L. Rock

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Centrosome defects can account for cellular and genetic changes that characterize prostate cancer progression, German A. Pihan, Aruna Purohit, Jan Wallace, Raji Malhotra, Lance A. Liotta, and Stephen J. Doxsey

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Plasma cell differentiation requires the transcription factor XBP-1, Andreas M. Reimold, Neal N. Iwakoshi, John Manis, Prashanth Vallabhajosyula, Eva Szomolanyi-Tsuda, Ellen M. Gravallese, Daniel Friend, Michael J. Grusby, Frederick Alt, and Laurie H. Glimcher

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Superior vena cava syndrome secondary to an angiotropic large cell lymphoma, Diane M. F. Savarese, Michael Zavarin, Mark S. Smyczynski, Michael J. Rohrer, and Michael J. Hutzler

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Innate immunity to viruses: control of vaccinia virus infection by gamma delta T cells, Liisa K. Selin, Paul A. Santolucito, Amelia K. Pinto, Eva Szomolanyi-Tsuda, and Raymond M. Welsh

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Independent regulation of lymphocytic choriomeningitis virus-specific T cell memory pools: relative stability of CD4 memory under conditions of CD8 memory T cell loss, Steven Michael Varga, Liisa K. Selin, and Raymond M. Welsh

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Immunopathology in RSV infection is mediated by a discrete oligoclonal subset of antigen-specific CD4(+) T cells, Steven Michael Varga, Xiaoting Z. Wang, Raymond M. Welsh, and Thomas J. Braciale

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High frequency of virus-specific interleukin-2-producing CD4(+) T cells and Th1 dominance during lymphocytic choriomeningitis virus infection, Steven Michael Varga and Raymond M. Welsh

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HAT activity is essential for CBP-1-dependent transcription and differentiation in Caenorhabditis elegans, Martin Victor, Yanxia Bei, Frederique Gay, Dominica Calvo, Craig C. Mello, and Yang Shi

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Assessing CD8 T cell number and dysfunction in the presence of antigen, Raymond M. Welsh

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BB rat thymocytes cultured in the presence of islets lose their ability to transfer autoimmune diabetes, Barbara J. Whalen, Jan Marounek, Peter Weiser, Michael C. Appel, Dale L. Greiner, John P. Mordes, and Aldo A. Rossini

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Requirement of the JIP1 scaffold protein for stress-induced JNK activation, Alan J. Whitmarsh, Chia-Yi Kuan, Norman J. Kennedy, Nyaya Kelkar, Tarik F. Haydar, John P. Mordes, Michael C. Appel, Aldo A. Rossini, Stephen N. Jones, Richard A. Flavell, Pasko Rakic, and Roger J. Davis

Publications from 2000

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A profound deficiency in thymic progenitor cells in mice lacking Jak3, Allison Michelle Baird, Julie Ann Lucas, and Leslie J. Berg

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Basic mechanisms of DNA-raised antibody responses to intramuscular and gene gun immunizations, Christine Margaret Boyle and Harriet L. Robinson

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Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade, Stephen C. Bunnell, Maximilian Diehn, Michael B. Yaffe, Paul R. Findell, Lewis C. Cantley, and Leslie J. Berg

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Evolution of the CD8 T-cell repertoire during infections, Meei-Yun Lin, Liisa K. Selin, and Raymond M. Welsh

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The virus-specific and allospecific cytotoxic T-lymphocyte response to lymphocytic choriomeningitis virus is modified in a subpopulation of CD8(+) T cells coexpressing the inhibitory major histocompatibility complex class I receptor Ly49G2, Craig D. Peacock, Meei-Yun Lin, John R. Ortaldo, and Raymond M. Welsh

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Characterization of Immune Responses Following Neonatal DNA Immunization: A Dissertation, Tamera Marie Pertmer

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Successful DNA immunization against measles: neutralizing antibody against either the hemagglutinin or fusion glycoprotein protects rhesus macaques without evidence of atypical measles, Fernando P. Polack, Sok H. Lee, Sallie R. Permar, Elizabeth Manyara, Hossein G. Nousari, Yaikah Jeng, Farah Mustafa, Alexandra Valsamakis, Robert J. Adams, Harriet L. Robinson, and Diane E. Griffin

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Attrition of T cell memory: selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses, Liisa K. Selin, Meei-Yun Lin, Kristy A. Kraemer, Drew M. Pardoll, Jonathan P. Schneck, Steven Michael Varga, Paul A. Santolucito, Amelia K. Pinto, and Raymond M. Welsh

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Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice, Edward Seung, Neal N. Iwakoshi, Bruce A. Woda, Thomas G. Markees, John P. Mordes, Aldo A. Rossini, and Dale L. Greiner

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Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses, Yan Shi, Wanyong Zeng, and Kenneth L. Rock

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Bone marrow-derived antigen-presenting cells are required for the generation of cytotoxic T lymphocyte responses to viruses and use transporter associated with antigen presentation (TAP)-dependent and -independent pathways of antigen presentation, Luis J. Sigal and Kenneth L. Rock

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The role of CD40-CD154 interaction in antiviral T cell-independent IgG responses, Eva Szomolanyi-Tsuda, James D. Brien, Jill E. Dorgan, Raymond M. Welsh, and Robert L. Garcea

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Viral infection abrogates CD8(+) T-cell deletion induced by costimulation blockade, Nicole A. Turgeon, Neal N. Iwakoshi, Nancy E. Phillips, William C. Meyers, Raymond M. Welsh, Dale L. Greiner, John P. Mordes, and Aldo A. Rossini

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Regulation of human cell engraftment and development of EBV-related lymphoproliferative disorders in Hu-PBL-scid mice, Eric J. Wagar, Mary A. Cromwell, Leonard D. Shultz, Bruce A. Woda, John L. Sullivan, RuthAnn M. Hesselton, and Dale L. Greiner

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The role of cell cycle regulatory protein, cyclin D1, in the progression of thyroid cancer, Songtao Wang, Ricardo V. Lloyd, Michael J. Hutzler, Marjorie Safran, Nilima A. Patwardhan, and Ashraf Khan

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Virus-induced abrogation of transplantation tolerance induced by donor-specific transfusion and anti-CD154 antibody, Raymond M. Welsh, Thomas G. Markees, Bruce A. Woda, Keith A. Daniels, Michael A. Brehm, John P. Mordes, Dale L. Greiner, and Aldo A. Rossini

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Tec kinase signaling in T cells is regulated by phosphatidylinositol 3-kinase and the Tec pleckstrin homology domain, Wen-Chin Yang, Keith A. Ching, Constantine D. Tsoukas, and Leslie J. Berg

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Bystander sensitization to activation-induced cell death as a mechanism of virus-induced immune suppression, Christopher C. Zarozinski, James M. McNally, Barbara L. Lohman, Keith A. Daniels, and Raymond M. Welsh

Publications from 1999

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Developmental regulation of thyrotropin receptor gene expression in the fetal and neonatal rat thyroid: relation to thyroid morphology and to thyroid-specific gene expression, Rosalind S. Brown, Victoria Shalhoub, Sarah Coulter, Sharon Alex, Isabelle Joris, William J. DeVito, Jane B. Lian, and Gary S. Stein

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Islet cell membrane antigens activate diabetogenic CD4+ T-cells in the BB/Wor rat, Karen E. Ellerman and Arthur A. Like

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DNA vaccines: vector design, delivery, and antigen presentation, David Marc Feltquate