The Department of Pathology at the University of Massachusetts Medical School is committed to excellence in the three areas that comprise its mission: the practice of anatomic and clinical pathology diagnosis and consultation for a large academic medical center and its community affiliates; the advancement of knowledge through basic and clinical research and the translation of advances from the laboratory to clinical practice; the training of medical and graduate students, clinical and research fellows, and pathology residents. This collection showcases the the journal articles, books, book chapters, and other publications and presentations written by faculty and researchers of the Department of Pathology.

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Publications from 2013

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Antigenic peptide trimming by ER aminopeptidases--insights from structural studies, Efstratios Stratikos and Lawrence J. Stern

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Multipronged CD4(+) T-cell effector and memory responses cooperate to provide potent immunity against respiratory virus, Tara M. Strutt, K. Kai McKinstry, Nikki B. Marshall, Allen M. Vong, Richard W. Dutton, and Susan L. Swain

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Generalized Spinous Follicular Lichen Nitidus with Perifollicular Granulomas, Heather S. Summe, Sheila M. Greenlaw, April Deng, Cynthia Magro, and Karen Wiss

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Immune senescence: new insights into defects but continued mystery of root causes, Susan L. Swain and Bonnie B. Blomberg

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The N-terminus of vaccinia virus host range protein C7L is essential for function, Masanori Terajima, Stina L. Urban, and Anita M. Leporati

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Advances in understanding the pathogenesis of HLH, G. Naheed Usmani, Bruce A. Woda, and Peter E. Newburger

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Viral antigen density and confinement time regulate the reactivity pattern of CD4 T-cell responses to vaccinia virus infection, Vijay Vanguri, Christopher Govern, Rebecca Smith, and Eric Huseby

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NK cells controlling virus-specific T cells: Rheostats for acute vs. persistent infections, Raymond M. Welsh and Stephen N. Waggoner

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Anti-IFN-gamma and peptide-tolerization therapies inhibit acute lung injury induced by cross-reactive influenza A-specific memory T cells, Myriam F. Wlodarczyk, Anke R. Kraft, Hong D. Chen, Laurie L. Kenney, and Liisa K. Selin

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A case of Hansen Disease presenting as tinea versicolor, Shelley Yang, Maryanne Makredes, Patrick O'Donnell, and Nikki A. Levin

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The Tec kinase ITK regulates thymic expansion, emigration, and maturation of gammadelta NKT cells, Catherine C. Yin, Ok Hyun Cho, Katelyn E. Sylvia, Kavitha Narayan, Amanda L. Prince, John W. Evans, Joonsoo Kang, and Leslie J. Berg

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CD4+ T Cells Provide Intermolecular Help To Generate Robust Antibody Responses in Vaccinia Virus-Vaccinated Humans, Liusong Yin, J. Mauricio Calvo-Calle, John Cruz Jr., Frances K. Newman, Sharon E. Frey, Francis A. Ennis, and Lawrence J. Stern

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Clinical implications of current developments in genitourinary pathology, Amy G Zhou, Christopher L. Owens, Ediz F. Cosar, and Zhong Jiang

Publications from 2012

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A human CD4+ T cell epitope in the influenza hemagglutinin is cross-reactive to influenza A virus subtypes and to influenza B virus, Jenny Aurielle B. Babon, John Cruz, Francis A. Ennis, Liusong Yin, and Masanori Terajima

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Fatty acid binding protein 4 is expressed in distinct endothelial and non-endothelial cell populations in glioblastoma, Oguz Cataltepe, Meltem Cevik Arikan, E Ghelfi, C Karaaslan, Y Ozsurekci, Y Li, T. W. Smith, Karen A. Dresser, and Sule Cataltepe

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Loss of anti-viral immunity by infection with a virus encoding a cross-reactive pathogenic epitope, Alex T. Chen, Markus Cornberg, Stephanie Gras, Carole Guillonneau, Jamie Rossjohn, Andrew Trees, Sebastien Emonet, Juan C. de la Torre, Raymond M. Welsh, and Liisa K. Selin

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Eruption of bullae within psoriatic plaques: a rare adverse effect of narrow-band ultraviolet B (NB-UVB) phototherapy, Kristen C. Corey, Nikki A. Levin, Michelle Hure, April Deng, and Jeffrey D. Mailhot

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On the Source of Peptides for Major Histocompatibility Class I Antigen Presentation: A Dissertation, Diego José Farfán Arribas

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ATM phosphorylation of Mdm2 Ser394 regulates the amplitude and duration of the DNA damage response in mice, Hugh S. Gannon, Bruce A. Woda, and Stephen N. Jones (Cancer cell)

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IL-1 generated subsequent to radiation-induced tissue injury contributes to the pathogenesis of radiodermatitis, Matthew Janko, Fernando Ontiveros, Thomas J. Fitzgerald, April Deng, Maria DeCicco, and Kenneth L. Rock

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Pretargeting vs. direct targeting of human betalox5 islet cells subcutaneously implanted in mice using an anti-human islet cell antibody, Guozheng Liu, Shuping Dou, Ali Akalin, Mary Rusckowski, Philip R. Streeter, Leonard D. Shultz, and Dale L. Greiner

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Radiolabeled Zn-DPA as a potential infection imaging agent, Xinrong Liu, Dengfeng Cheng, Brian D. Gray, Yuzhen Wang, Ali Akalin, Mary Rusckowski, Koon Y. Pak, and Donald J. Hnatowich

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Distinct Gene Circuits Control the Differentiation of Innate Versus Adaptive IL-17 Producing T Cells: A Dissertation, Nidhi Malhotra

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Allele- and tir-independent functions of intimin in diverse animal infection models, Emily M. Mallick, Michael J. Brady, Steven A. Luperchio, Vijay K. Vanguri, Loranne Magoun, Hui Liu, Barbara J. Sheppard, Jean Mukherjee, Arthur Donohue-Rolfe, Saul Tzipori, John M. Leong, and David B. Schauer

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A novel murine infection model for Shiga toxin-producing Escherichia coli, Emily M. Mallick, Megan E. McBee, Vijay K. Vanguri, Angela R. Melton-Celsa, Katherine Schlieper, Brad J. Karalius, Alison D. O’Brien, Joan R. Butterton, John M. Leong, and David B. Schauer

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Human CD4+ T cell response to human herpesvirus 6, Maria-Dorothea Nastke, Aniuska Becerra, Liusong Yin, Omar Dominguez-Amorocho, Laura L. Gibson, Lawrence J. Stern, and J. Mauricio Calvo-Calle

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TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation, Ribhu Nayar, Megan E. Enos, Amanda L. Prince, HyunMu Shin, Saskia Hemmers, Jian-kang Jiang, Ulf Klein, Craig J. Thomas, and Leslie J. Berg

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Diagnostic Patterns and Immunohistochemical Stain Usage in Extended Core Prostate Biopsies: Comparisons Between Genitourinary and Non-Genitourinary Pathologists, Anna Plourde, Zhong Jiang, and Christopher L. Owens

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Smurf2 regulates the senescence response and suppresses tumorigenesis in mice, Charusheila Ramkumar, Yahui Kong, Hang Cui, Suyang Hao, Stephen N. Jones, Rachel M. Gerstein, and Hong Zhang (Cancer research)

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Innate Signaling Pathways in the Maintenance of Serological Memory: A Dissertation, Forum M. Raval

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Molecular Studies of T Cell Recognition and Cross-Reactivity: A Dissertation, Zu T. Shen

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Mohs micrographic surgery for recurrent chondroid syringoma of the eyebrow, Andrew C. Walls, April Deng, and David E. Geist

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The Role of Heterologous Immunity in Mediating Natural Resistance to Infection in Human Subjects: A Dissertation, Levi B. Watkin

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Type 1 interferons and antiviral CD8 T-cell responses, Raymond M. Welsh, Kapil Bahl, Heather D. Marshall, and Stina L. Urban

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The Role of ITK in the Development of Gamma Delta NKT Cells: A Dissertation, Catherine C. Yin

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Feasibility demonstration of frequency domain terahertz imaging in breast cancer margin determination, Sigfrid K. Yngvesson, Benjamin St Peter, Paul Siqueira, Patrick Kelly, Stephen J. Glick, Andrew Karellas, and Ashraf Khan

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The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells, Haojian Zhang, Cong Peng, Yiguo Hu, Huawei Li, Zhi Sheng, Yaoyu Chen, Con Sullivan, Jan Cerny, Lloyd Hutchinson, Anne Higgins, Patricia M. Miron, Xueqing Zhang, Michael A. Brehm, Dongguang Li, Michael R. Green, and Shaoguang Li

Publications from 2011

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Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease, Jacinta Bustamante, Andres A. Arias, Guillaume Vogt, Capucine Picard, Lizbeth Blancas Galicia, Carolina Prando, Audrey V. Grant, Christophe C. Marchal, Marjorie Hubeau, Ariane Chapgier, Ludovic de Beaucoudrey, Anne Puel, Jacqueline Feinberg, Ethan Valinetz, Lucile Janniere, Celine Besse, Anne Boland, Jean-Marie Brisseau, Stephane Blanche, Olivier Lortholary, Claire Fieschi, Jean-Francois Emile, Stephanie Boisson-Dupuis, Saleh Al-Muhsen, Bruce A. Woda, Peter E. Newburger, Antonio Condino-Neto, Mary C. Dinauer, Laurent Abel, and Jean-Laurent Casanova

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RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation, YoungSik Cho, Thomas McQuade, Haibing Zhang, Jianke Zhang, and Francis Ka-Ming Chan

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Dermal melanoma in a transplant patient, Elizabeth Foley, Sheila M. Greenlaw, Jason Givan, April C. Deng, Mary E. Maloney, and David E. Geist

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Genetic Disorders, Marzena Galdzicka and Edward I. Ginns

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Mice completely lacking immunoproteasomes show major changes in antigen presentation, Eleanor Z. Kincaid, Jenny Wun-Yue Che, Ian York, Hernando Escobar, Eduardo Reyes-Vargas, Julio C. Delgado, Raymond M. Welsh, Margaret L. Karow, Andrew J. Murphy, David M. Valenzuela, George D. Yancopoulos, and Kenneth L. Rock

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IMP3, a new biomarker to predict progression of cervical intraepithelial neoplasia into invasive cancer, Di Lu, Xiaofang Yang, Naomi Y. Jiang, Bruce A. Woda, Qin Liu, Karen A. Dresser, Arthur M. Mercurio, Kenneth L. Rock, and Zhong Jiang

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Metastatic squamous cell carcinoma of the vulva mimicking primary varicella-zoster virus infection, Jeffrey D. Mailhot, Patrick O'Donnell, Rujing Han, Susan L. Zweizig, and David E. Geist

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Cytotoxic CD4 T cells in antiviral immunity, Nikki B. Marshall and Susan L. Swain

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The Function of Innate γδ T Cell Subsets is Molecularly Programmed in the Thymus in Three Stages: A Dissertation, Kavitha Narayan

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Effect of Paget's disease on survival in breast cancer: an exploratory study, Sonia Ortiz-Pagan, Gina Cunto-Amesty, Sandeep Narayan, Sybil L. Crawford, Chase Derrick, Anne C. Larkin, Ashraf Khan, Robert M. Quinlan, and Rakhshanda Layeequr Rahman

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Effect of Paget's disease on survival in breast cancer: an exploratory study, Sonia Ortiz-Pagan, Gina Cunto-Amesty, Sandeep Narayan, Sybil L. Crawford, Chase Derrick, Anne C. Larkin, Ashraf Khan, Robert M. Quinlan, and Rakhshanda Layeequr Rahman

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Conformational Lability in MHC II Proteins: A Dissertation, Corrie A. Painter

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Conformational lability in the class II MHC 3-10 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange, Corrie A. Painter, Maria P. Negroni, Kathy A. Kellersberger, Zarixia Zavala-Ruiz, James E. Evans, and Lawrence J. Stern

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Heterologous immunity: immunopathology, autoimmunity and protection during viral infections, Liisa K. Selin, Myriam F. Wlodarczyk, Anke R.M. Kraft, Siwei Nie, Laurie L. Kenney, Roberto Puzone, and Franco Celada

Publications from 2010

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Analysis of apoptosis of memory T cells and dendritic cells during the early stages of viral infection or exposure to toll-like receptor agonists, Kapil Bahl, Anette Hubner, Roger J. Davis, and Raymond M. Welsh

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Heritability of apnea of prematurity: a retrospective twin study, Elisabeth Bloch-Salisbury, Mei Hua Hall, Priya Sharma, Theonia Boyd, Francis J. Bednarek, and David Paydarfar

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Neurological picture. Ascending paralysis from malignant leptomeningeal melanomatosis, Anthony M. Burrows, Thomas W. Smith, Wiley R. Hall, and Julie G. Pilitsis

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Hemophagocytic lymphohistiocytosis with MUNC13-4 gene mutation or reduced natural killer cell function prior to onset of childhood leukemia, Tamara Y. Chang, Julie Jaffray, Bruce A. Woda, Peter E. Newburger, and G. Naheed Usmani

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Regulation of Immune Pathogenesis by Antigen-Specific CD8 T Cells Following Sequential Heterologous Infections: A Dissertation, Alex T. Chen

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Broad cross-reactive TCR repertoires recognizing dissimilar Epstein-Barr and influenza A virus epitopes, Shalyn Catherine Clute, Yuri N. Naumov, Levi B. Watkin, Nuray Aslan, John L. Sullivan, David A. Thorley-Lawson, Katherine Luzuriaga, Raymond M. Welsh, Roberto Puzone, Franco Celada, and Liisa K. Selin

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CD8 T cell cross-reactivity networks mediate heterologous immunity in human EBV and murine vaccinia virus infections, Markus Cornberg, Shalyn Catherine Clute, Levi B. Watkin, Frances M. Saccoccio, Sung-Kwon Kim, Yuri N. Naumov, Michael A. Brehm, Nuray Aslan, Raymond M. Welsh, and Liisa K. Selin

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals, Peter Duewell, Hajime Kono, Katey J. Rayner, Cherilyn M. Sirois, Gregory Vladimer, Franz G. Bauernfeind, George S. Abela, Luigi Franchi, Gabriel Nuñez, Max Schnurr, Terje Espevik, Egil Lien, Katherine A. Fitzgerald, Kenneth L. Rock, Kathryn J. Moore, Samuel D. Wright, Veit Hornung, and Eicke Latz

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p53 represses class switch recombination to IgG2a through its antioxidant function, Jeroen E. J. Guikema, Carol E. Schrader, Michael H. Brodsky, Erin K. Linehan, Adam Richards, Nahla El Falaky, Daniel H. LI, Hayla Karen Sluss, Eva Szomolanyi-Tsuda, and Janet Stavnezer

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Pseudo-merohedral twinning and noncrystallographic symmetry in orthorhombic crystals of SIVmac239 Nef core domain bound to different-length TCRzeta fragments., Walter Minsub Kim, Alexander B. Sigalov, and Lawrence J. Stern

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Uric acid promotes an acute inflammatory response to sterile cell death in mice, Hajime Kono, Chun-Jen Chen, Fernando Ontiveros, and Kenneth L. Rock

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A preclinical 188Re tumor therapeutic investigation using MORF/cMORF pretargeting and an antiTAG-72 antibody CC49, Guozheng Liu, Shuping Dou, Stephen P. Baker, Ali Akalin, Dengfeng Cheng, Ling Chen, Mary Rusckowski, and Donald J. Hnatowich

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IFN-alpha beta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions, Heather D. Marshall, Amanda L. Prince, Leslie J. Berg, and Raymond M. Welsh

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NK cells and gammadelta T cells mediate resistance to polyomavirus-induced tumors, Rabinarayan Mishra, Alex T. Chen, Raymond M. Welsh, and Eva Szomolanyi-Tsuda

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Disorderly conduct in gammadelta versus alphabeta T cell lineage commitment, Kavitha Narayan and Joonso Kang

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Structural and Functional Studies of Proteins Involved in Antigen Processing: A Dissertation, Tina T. Nguyen

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Maturation-dependent licensing of naive T cells for rapid TNF production, Bhavana Priyadharshini, Raymond M. Welsh, Dale L. Greiner, Rachel M. Gerstein, and Michael A. Brehm

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The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses, Vijay A.K. Rathinam, Zhaozhao Jiang, Stephen N. Waggoner, Shrutie Sharma, Leah E. Cole, Lisa Waggoner, Sivapriya Kailasan Vanaja, Brian G. Monks, Sandhya Ganesan, Eicke Latz, Veit Hornung, Stefanie N. Vogel, Eva Szomolanyi-Tsuda, and Katherine A. Fitzgerald

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Immunity, Pathogenesis, and Prevention of Poxvirus Infections: A Dissertation, Mina O. Seedhom

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A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications, Zhi Sheng, Li Li, Lihua Julie Zhu, Thomas W. Smith, Andrea Demers, Alonzo H. Ross, Richard P. Moser, and Michael R. Green

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Bi-specific MHC heterodimers for characterization of cross-reactive T cells, Zu T. Shen, Michael A. Brehm, Keith A. Daniels, Alexander B. Sigalov, Liisa K. Selin, Raymond M. Welsh, and Lawrence J. Stern

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Absence of mouse 2B4 promotes NK cell-mediated killing of activated CD8+ T cells, leading to prolonged viral persistence and altered pathogenesis, Stephen N. Waggoner, Ruth T. Taniguchi, Porunelloor A. Mathew, Vinay Kumar, and Raymond M. Welsh

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Heterologous immunity between viruses, Raymond M. Welsh, Jenny Wun-Yue Che, Michael A. Brehm, and Liisa K. Selin

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TLR4 is a negative regulator in noninfectious lung inflammation, Hang Zhao, Shaw-Wei Leu, Liyun Shi, Rejmon Dedaj, Gaofeng Zhao, Hari G. Garg, Lianjun Shen, Egil Lien, Katherine A. Fitzgerald, Aviva Shiedlin, Huahao Shen, Deborah A. Quinn, and Charles A. Hales

Publications from 2009

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Prostate cancer regulatory networks, Dario C. Altieri, Lucia R. Languino, Jane B. Lian, Janet L. Stein, Irwin Leav, Andre J. Van Wijnen, Zhong Jiang, and Gary S. Stein (Journal of cellular biochemistry)

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Dysembryoplastic neuroepithelial tumor located in pericallosal and intraventricular area in a child. Case report, Oguz Cataltepe, Paul C. Marshall, and Thomas W. Smith

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Tec kinase Itk in gammadeltaT cells is pivotal for controlling IgE production in vivo, Martin Felices, Catherine C. Yin, Yoko Kosaka, Joonsoo Kang, and Leslie J. Berg

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CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance, Randall H. Friedline, David S. Brown, Hai Nguyen, Hardy Kornfeld, Jinhee Lee, Yi Zhang, Mark Appleby, Sandy D. Der, Joonsoo Kang, and Cynthia A. Chambers

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Generation of protective T cell-independent antiviral antibody responses in SCID mice reconstituted with follicular or marginal zone B cells, Heath M. Guay, Rabinarayan Mishra, Robert L. Garcea, Raymond M. Welsh, and Eva Szomolanyi-Tsuda

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Leptomeningeal carcinomatosis: a rare complication in esophageal cancer, Nils Henninger, E. Lin, A. Fischer, and A. Kheradmand

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Multifaceted Regulation of Peripheral T Cell Tolerance and Autoimmunity by FOXP3+ T Regulatory Cells: A Dissertation, Nitya Jain

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Characterization of the Nef-TCR Zeta Interaction and Its Role in Modulation of Src Family Kinase Activity: A Dissertation, Walter Minsub Kim

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Cell polarity protein Lgl2 is lost or aberrantly localized in gastric dysplasia and adenocarcinoma: an immunohistochemical study, Mikhail Lisovsky, Karen A. Dresser, Stephen P. Baker, Andrew Fisher, Bruce A. Woda, Barbara F. Banner, and Gregory Y. Lauwers

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Auger radiation-induced, antisense-mediated cytotoxicity of tumor cells using a 3-component streptavidin-delivery nanoparticle with 111In, Xinrong Liu, Yi Wang, Kayoko Nakamura, Sumi Kawauchi, Ali Akalin, Dengfeng Cheng, Ling Chen, Mary Rusckowski, and Donald J. Hnatowich

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Sensitization of CD8 T Cells During Acute Viral Infections Impacts Bystander and Latecomer CD8 T Cell Responses : A Dissertation, Heather D. Marshall

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CD4 T-cell-mediated heterologous immunity between mycobacteria and poxviruses, Keisha S. Mathurin, Gregory W. Martens, Hardy Kornfeld, and Raymond M. Welsh

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TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade, David M. Miller, Thomas B. Thornley, Todd Pearson, Annie J. Kruger, Masahiro Yamazaki, Leonard D. Shultz, Raymond M. Welsh, Michael A. Brehm, Aldo A. Rossini, and Dale L. Greiner

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CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells, Steven C. Pino, Bryan O'Sullivan-Murphy, Erich A. Lidstone, Chaoxing Yang, Kathryn L. Lipson, Agata Jurczyk, Philip J. Diiorio, Michael A. Brehm, John P. Mordes, Dale L. Greiner, Aldo A. Rossini, and Rita Bortell

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The hair follicle barrier to involvement by malignant melanoma, Olga Pozdnyakova, Joseph Grossman, Belinda Barbagallo, and Stephen Lyle

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The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development, Amanda L. Prince, Catherine C. Yin, Megan E. Enos, Martin Felices, and Leslie J. Berg

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Long-term minocycline use for acne in healthy adolescents can cause severe autoimmune hepatitis, Jyoti P. Ramakrishna, Amy R. Johnson, and Barbara F. Banner

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Pathobiology of inflammation to cell death, Kenneth L. Rock

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Characterization of a novel interaction between transcription factor TFII-I and the inducible tyrosine kinase in T cells., Catarina Sacristan, Stefan A. Schattgen, Leslie J. Berg, Stephen C. Bunnell, Ananda L. Roy, and Yvonne Rosenstein

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Novel mechanistic insights into viral modulation of immune receptor signaling, Alexander B. Sigalov

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Duodenal diverticulum: case report of a perforated extraluminal diverticulum containing ectopic pancreatic tissue, Japa Volchok, Tareq Massimi, Sarah Wilkins, and Eugene L. Curletti

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c-Abl, an additional tyrosine kinase required for T cell development and function, Wenfang Wu and Leslie J. Berg

Publications from 2008

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Attrition of CD8 T Cells during the Early Stages of Viral Infections: a Dissertation, Kapil Bahl

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L-theanine intervention enhances human gammadeltaT lymphocyte function, Jack F. Bukowski and Susan S. Percival

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Transcriptional repression of the RUNX3/AML2 gene by the t(8;21) and inv(16) fusion proteins in acute myeloid leukemia, Chi-Keung Cheng, Libby Li, Suk-Hang Cheng, Kin-Mang Lau, Natalie P. H. Chan, Raymond S. M. Wong, Matthew M. K. Shing, Chi-Kong Li, and Margaret H. L. Ng