Title
Osteofibrous dysplasia and adamantinoma
UMMS Affiliation
Department of Orthopedics and Physical Rehabilitation
Publication Date
6-1-2010
Document Type
Article
Subjects
Adamantinoma; Bone Neoplasms; Diagnosis, Differential; Fibrous Dysplasia of Bone; Humans; Neoplasm Staging; Prognosis
Disciplines
Orthopedics | Rehabilitation and Therapy
Abstract
Osteofibrous dysplasia (OFD) is a rare, benign, fibro-osseous lesion that typically is seen within the cortex of the tibia in children. Adamantinoma (AD) is a rare, low-grade malignant primary bone tumor that occurs most often in the tibia and/or fibula of adolescent persons and young adults; however, it has been reported in other long bones, as well. Immunohistochemical and ultrastructural evidence has shown that the neoplastic cell in AD derives from an epithelial lineage. More recently, published reports have described another clinical entity-differentiated or OFD-like AD-that appears to lie between OFD and AD along a spectrum of disease. Controversy exists as to whether OFD is a precursor lesion to AD or whether OFD may be a residual lesion resulting from a spontaneously regressing AD. Management of OFD varies from observation to surgical intervention, depending on the age of the patient and the extent of the lesion. Management of AD requires surgical resection with wide margins, followed by appropriate reconstruction, to minimize the risk of local recurrence or metastasis.
Source
J Am Acad Orthop Surg. 2010 Jun;18(6):358-66.
Journal/Book/Conference Title
The Journal of the American Academy of Orthopaedic Surgeons
Related Resources
PubMed ID
20511441
Repository Citation
Most, Mathew J.; Sim, Franklin H.; and Inwards, Carrie Y., "Osteofibrous dysplasia and adamantinoma" (2010). Orthopedics and Physical Rehabilitation Publications and Presentations. 75.
https://escholarship.umassmed.edu/ortho_pp/75