Racial and ethnic disparities in disease activity in patients with rheumatoid arthritis
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Authors
Greenberg, Jeffrey D.Spruill, Tanya M.
Shan, Ying
Reed, George W.
Kremer, Joel M.
Potter, Jeffrey
Yazici, Yusuf
Ogedegbe, Gbenga
Harrold, Leslie R.
UMass Chan Affiliations
Department of Medicine, Division of Preventive and Behavioral MedicineDepartment of Orthopedics and Physical Rehabilitation
Document Type
Journal ArticlePublication Date
2013-12-01Keywords
Arthritis, RheumatoidCohort Studies
*Continental Population Groups
*Ethnic Groups
Health Status Disparities
Humans
Odds Ratio
Risk Factors
United States
Disease activity
Disparities
Rheumatoid arthritis
Clinical Epidemiology
Epidemiology
Musculoskeletal Diseases
Rheumatology
Metadata
Show full item recordAbstract
BACKGROUND: Observational studies of patients with rheumatoid arthritis have suggested that racial and ethnic disparities exist for minority populations. We compared disease activity and clinical outcomes across racial and ethnic groups using data from a large, contemporary US registry. METHODS: We analyzed data from 2 time periods (2005-2007 and 2010-2012). The Clinical Disease Activity Index was examined as both a continuous measure and a dichotomous measure of disease activity states. Outcomes were compared in a series of cross-sectional and longitudinal multivariable regression models. RESULTS: For 2005-2007, significant differences of mean disease activity level (P < .001) were observed across racial and ethnic groups. Over the 5-year period, modest improvements in disease activity were observed across all groups, including whites (3.7; 95% confidence interval [CI], 3.2-4.1) compared with African Americans (4.3; 95% CI, 2.7-5.8) and Hispanics (2.7; 95% CI, 1.2-4.3). For 2010-2012, significant differences of mean disease activity level persisted (P < .046) across racial and ethnic groups, ranging from 11.6 (95% CI, 10.4-12.8) in Hispanics to 10.7 (95% CI, 9.6-11.7) in whites. Remission rates remained significantly different across racial/ethnic groups across all models for 2010-2012, ranging from 22.7 (95% CI, 19.5-25.8) in African Americans to 27.4 (95% CI, 24.9-29.8) in whites. CONCLUSIONS: Despite improvements in disease activity across racial and ethnic groups over a 5-year period, disparities persist in disease activity and clinical outcomes for minority groups versus white patients.Source
Greenberg JD, Spruill TM, Shan Y, Reed G, Kremer JM, Potter J, Yazici Y, Ogedegbe G, Harrold LR. Racial and ethnic disparities in disease activity in patients with rheumatoid arthritis. Am J Med. 2013 Dec;126(12):1089-98. doi:10.1016/j.amjmed.2013.09.002. Link to article on publisher's site
DOI
10.1016/j.amjmed.2013.09.002Permanent Link to this Item
http://hdl.handle.net/20.500.14038/42960PubMed ID
24262723Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.amjmed.2013.09.002