Title

PGE(2) and BMP-2 in bone and cartilage metabolism: 2 intertwining pathways

UMMS Affiliation

Department of Orthopedics and Physical Rehabilitation

Publication Date

2012-11

Document Type

Article

Subjects

Dinoprostone; Bone Morphogenetic Protein 2; Osteoblasts; Osteoclasts; Osteogenesis; Prostaglandins

Disciplines

Orthopedics | Physiology

Abstract

Osteoarthritis and lesions to cartilage tissue are diseases that frequently result in impaired joint function and patient disability. The treatment of osteoarthritis, along with local bone defects and systemic skeletal diseases, remains a significant clinical challenge for orthopaedic surgeons. Several bone morphogenetic proteins (BMPs) are known to have osteoinductive effects, whereof BMP-2 and BMP-7 are already approved for clinical applications. There is growing evidence that the metabolism of bone as well as the cartilage damage associated with the above disease processes are strongly inter-related with the interactions of the inflammation-related pathways (in particular prostaglandin E(2) (PGE(2))) and osteogenesis (in particular bone morphogenetic protein-2 (BMP-2)). There is strong evidence that the pathways of prostaglandins and bone morphogenetic proteins are intertwined, and they have recently come into focus in several experimental and clinical studies. This paper focuses on PGE(2) and BMP-2 intertwining pathways in bone and cartilage metabolism, and summarizes the recent experimental and clinical data.

DOI of Published Version

10.1139/y2012-123

Source

Can J Physiol Pharmacol. 2012 Nov;90(11):1434-45. doi: 10.1139/y2012-123. Link to article on publisher's site

Journal/Book/Conference Title

Canadian journal of physiology and pharmacology

Related Resources

Link to Article in PubMed

PubMed ID

23181272

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