Title
PGE(2) and BMP-2 in bone and cartilage metabolism: 2 intertwining pathways
UMMS Affiliation
Department of Orthopedics and Physical Rehabilitation
Publication Date
2012-11
Document Type
Article
Subjects
Dinoprostone; Bone Morphogenetic Protein 2; Osteoblasts; Osteoclasts; Osteogenesis; Prostaglandins
Disciplines
Orthopedics | Physiology
Abstract
Osteoarthritis and lesions to cartilage tissue are diseases that frequently result in impaired joint function and patient disability. The treatment of osteoarthritis, along with local bone defects and systemic skeletal diseases, remains a significant clinical challenge for orthopaedic surgeons. Several bone morphogenetic proteins (BMPs) are known to have osteoinductive effects, whereof BMP-2 and BMP-7 are already approved for clinical applications. There is growing evidence that the metabolism of bone as well as the cartilage damage associated with the above disease processes are strongly inter-related with the interactions of the inflammation-related pathways (in particular prostaglandin E(2) (PGE(2))) and osteogenesis (in particular bone morphogenetic protein-2 (BMP-2)). There is strong evidence that the pathways of prostaglandins and bone morphogenetic proteins are intertwined, and they have recently come into focus in several experimental and clinical studies. This paper focuses on PGE(2) and BMP-2 intertwining pathways in bone and cartilage metabolism, and summarizes the recent experimental and clinical data.
DOI of Published Version
10.1139/y2012-123
Source
Can J Physiol Pharmacol. 2012 Nov;90(11):1434-45. doi: 10.1139/y2012-123. Link to article on publisher's site
Journal/Book/Conference Title
Canadian journal of physiology and pharmacology
Related Resources
PubMed ID
23181272
Repository Citation
Haversath M, Catelas I, Li X, Tassemeier T, Jager M. (2012). PGE(2) and BMP-2 in bone and cartilage metabolism: 2 intertwining pathways. Orthopedics and Physical Rehabilitation Publications. https://doi.org/10.1139/y2012-123. Retrieved from https://escholarship.umassmed.edu/ortho_pp/125