Soluble endoglin for the prediction of preeclampsia in a high risk cohort
Department of Medicine, Division of Preventive and Behavioral Medicine; Department of Obstetrics and Gynecology
Adult; Antigens, CD; Biological Markers; Enzyme-Linked Immunosorbent Assay; Female; Humans; Pre-Eclampsia; Pregnancy; Pregnancy Proteins; Pregnancy, High-Risk; Pregnancy, Multiple; Receptors, Cell Surface; Risk Factors; Vascular Endothelial Growth Factor Receptor-1
Obstetrics and Gynecology
OBJECTIVES: To evaluate soluble endoglin (sEng) and the soluble fms-like tyrosine kinase 1 (sFlt1) to placental growth factor (PlGF) ratio for the prediction of preeclampsia in high-risk women, and to evaluate differences in sEng between women with high-risk singleton and multiple gestation pregnancies.
STUDY DESIGN: We collected serial serum specimens from 119 women at high preeclampsia risk. sEng, sFlt1 and PlGF were measured by ELISA.
RESULTS: Among subjects who did not develop preeclampsia, mean serum sEng was significantly higher in those with multiple gestation pregnancies vs. high-risk singletons. Among women with singleton gestations, mean serum sEng was higher in subjects who developed early-onset (<34 >weeks) and late-onset (>or= 34 weeks) preeclampsia, as compared with subjects without preeclampsia, from 22 weeks and 28 weeks gestation onward, respectively. The within-woman rate of change of sEng was also higher in women who later developed preeclampsia.
CONCLUSIONS: sEng is higher in women with multiple gestations vs. high-risk singleton pregnancies. In high-risk women, serum sEng is increased prior to preeclampsia onset.
DOI of Published Version
Hypertens Pregnancy. 2010;29(3):330-41. Link to article on publisher's site
Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy
Maynard SE, Moore Simas TA, Bur L, Crawford SL, Solitro MJ, Meyer BA. (2010). Soluble endoglin for the prediction of preeclampsia in a high risk cohort. Obstetrics and Gynecology Publications. https://doi.org/10.3109/10641950902968684. Retrieved from https://escholarship.umassmed.edu/obgyn_pp/8