Endometrial histology following 1 year of a continuous daily regimen of levonorgestrel 90 micro g/ethinyl estradiol 20 micro g

UMMS Affiliation

Department of Obstetrics and Gynecology

Publication Date


Document Type



Adolescent; Adult; Contraceptive Agents, Female; Endometrium; Estrogens; Ethinyl Estradiol; Female; Humans; Levonorgestrel; Metrorrhagia; Middle Aged; Safety; Treatment Outcome


Obstetrics and Gynecology


OBJECTIVE: The objective of this study was to evaluate the effect of a continuous daily regimen of levonorgestrel (LNG) 90 micro g/ethinyl estradiol (EE) 20 micro g on endometrial histology.

METHODS: This was a substudy of a large phase 3 trial conducted in six sites in North America. Healthy and sexually active women aged between 18 and 49 years took LNG 90 micro g/EE 20 micro g daily for 1 year. Results from endometrial biopsies performed at pretreatment baseline and those after at least 6 months of treatment were compared. RESULTS: Of the 146 participants, 93 had a baseline biopsy and completed at least six pill packs. Before treatment, 56 subjects (60%) had an endometrial biopsy with findings classified as "weakly proliferative or proliferative." During the last on-therapy visit, 48 subjects (52%) had an endometrium categorized as "other," which included primarily an inactive or benign endometrium (n=42). No hyperplasia or malignancy was observed during the study.

CONCLUSION: The results of a 1-year continuous regimen of LNG 90 micro g/EE 20 micro g were shown to have a good endometrial safety profile.

DOI of Published Version



Contraception. 2007 Jan;75(1):23-6. Epub 2006 Sep 7. Link to article on publisher's site

Journal/Book/Conference Title



At the time of publication, Julia Johnson was not yet affiliated with the University of Massachusetts Medical School.

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Link to Article in PubMed

PubMed ID