Title

Correlation of serum androgens with anthropometric and metabolic indices in healthy, nonobese postmenopausal women

UMMS Affiliation

Department of Obstetrics and Gynecology

Publication Date

9-23-2010

Document Type

Article

Subjects

Aged; Androgens; *Body Weights and Measures; Cohort Studies; Cross-Sectional Studies; Female; Health; Health Status Indicators; Humans; Ideal Body Weight; Male; *Metabolome; Middle Aged; Postmenopause; Statistics as Topic; Testosterone

Disciplines

Obstetrics and Gynecology

Abstract

OBJECTIVE: The role of testosterone in the regulation of metabolic and physiological function in men is well defined, but its role in women remains enigmatic. Thus, the present study sought to assess the contribution of endogenous circulating androgens to the regulation of metabolic function, body morphometry, and physical function in normal naturally postmenopausal women.

METHODS: Using a cross-sectional design, we measured serum androgens in a cohort of 29 naturally postmenopausal women and correlated the results with metabolic, morphometric, and functional outcome parameters. These included insulin sensitivity, whole-body fat and lean body mass, visceral/abdominal fat areasm and aerobic capacity.

RESULTS: Higher serum testosterone levels were related to greater maximal aerobic capacity and reduced adiposity. Additionally, higher serum dihydrotestosterone, dehydroepiandrosterone sulfate, androstenedione, and androstenetriol glucuronidate levels were correlated to greater insulin sensitivity.

CONCLUSION: In naturally postmenopausal women, endogenous androgens may play a role in the maintenance of beneficial patterns of metabolic, morphometric, and functional parameters.

DOI of Published Version

10.1210/jc.2009-2390

Source

J Clin Endocrinol Metab. 2010 Sep;95(9):4276-82. Epub 2010 Jun 21. Link to article on publisher's site

Journal/Book/Conference Title

The Journal of clinical endocrinology and metabolism

Related Resources

Link to Article in PubMed

PubMed ID

20566621

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