Verrucous carcinoma of the endometrium: case history, pathologic findings, brief review of literature and discussion
Department of Obstetrics and Gynecology
Aged; Carcinoma, Verrucous; Endometrial Neoplasms; Female; Humans
Obstetrics and Gynecology
BACKGROUND: Verrucous carcinoma is a rare condition. A defined disease of the oral cavity, larynx, esophagus, skin, vulva, vagina and cervix. But a verrucous carcinoma arising from the endometrium without evidence of cervical malignancy or endometrial adenocarcinoma is extremely rare.
CASE: A 67-year-old G2P2 menopausal patient that was referred for consultation 1 year after presenting with vaginal bleeding to her gynecologist who subsequently underwent several endometrial biopsies where the pathological findings were repetitively similar: papillary squamous proliferation, cytologically bland with low mitotic activity but extensive proliferation. A hysterectomy with bilateral salpingo-oophorectomy was performed. The final histologic examination revealed a squamous cell carcinoma of endometrium, verrucous and well differentiated, and there was no cervical invasion identified.
CONCLUSION: This is a rare form of endometrial cancer with apparent favorable prognosis that must be considered when squamous cells are identified on endometrial samplings.
DOI of Published Version
Gynecol Oncol. 2006 Aug;102(2):375-7. Epub 2006 Mar 10. Link to article on publisher's site
Illanes DS, Broman J, Meyer BA, Kredentser D, McElrath T, Timmins P. (2006). Verrucous carcinoma of the endometrium: case history, pathologic findings, brief review of literature and discussion. Obstetrics and Gynecology Publications. https://doi.org/10.1016/j.ygyno.2006.01.046. Retrieved from https://escholarship.umassmed.edu/obgyn_pp/23