Verrucous carcinoma of the endometrium: case history, pathologic findings, brief review of literature and discussion

UMMS Affiliation

Department of Obstetrics and Gynecology



Document Type


Medical Subject Headings

Aged; Carcinoma, Verrucous; Endometrial Neoplasms; Female; Humans


Obstetrics and Gynecology


BACKGROUND: Verrucous carcinoma is a rare condition. A defined disease of the oral cavity, larynx, esophagus, skin, vulva, vagina and cervix. But a verrucous carcinoma arising from the endometrium without evidence of cervical malignancy or endometrial adenocarcinoma is extremely rare.

CASE: A 67-year-old G2P2 menopausal patient that was referred for consultation 1 year after presenting with vaginal bleeding to her gynecologist who subsequently underwent several endometrial biopsies where the pathological findings were repetitively similar: papillary squamous proliferation, cytologically bland with low mitotic activity but extensive proliferation. A hysterectomy with bilateral salpingo-oophorectomy was performed. The final histologic examination revealed a squamous cell carcinoma of endometrium, verrucous and well differentiated, and there was no cervical invasion identified.

CONCLUSION: This is a rare form of endometrial cancer with apparent favorable prognosis that must be considered when squamous cells are identified on endometrial samplings.

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Citation: Gynecol Oncol. 2006 Aug;102(2):375-7. Epub 2006 Mar 10. Link to article on publisher's site

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