Open Access is free, unrestricted, online access to scientific and scholarly research. This collection includes Open Access journal articles authored by researchers, faculty, staff, and students of the University of Massachusetts Medical School.

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Publications from 2020

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Long Non-coding RNA LincRNA-EPS Inhibits Host Defense Against Listeria monocytogenes Infection, Federica Agliano, Katherine A. Fitzgerald, Anthony T. Vella, Vijay A. Rathinam, and Andrei E. Medvedev

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Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD, Nadja S. Andrade, Abbas Abdallah, Christian Mueller, and Zane Zeier

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Declines in Lung Function After Antiretroviral Therapy Initiation in Adults With Human Immunodeficiency Virus and Tuberculosis: A Potential Manifestation of Respiratory Immune Reconstitution Inflammatory Syndrome, Sara C. Auld, Pholo Maenetje, Shruthi Ravimohan, Drew Weissman, Itai Ncube, Mandla Mlotshwa, Nelly Ratsela, William Chase, Mboyo-Di-Tamba Vangu, Robert Wallis, Gavin Churchyard, Hardy Kornfeld, and Gregory P. Bisson

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Skp, Cullin, F-box (SCF)-Met30 and SCF-Cdc4-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A for Chromosomal Stability in Budding Yeast, Wei-Chun Au, Richard E. Baker, and Munira A. Basrai

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A Unique Presentation of Cutaneous Diffuse Large B-Cell Lymphoma, Mary Awad, Erik Holzwanger, and Sandeep Jubbal

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Tumor cell-organized fibronectin maintenance of a dormant breast cancer population, Lauren E. Barney, Christopher L. Hall, Alyssa D. Schwartz, Akia N. Parks, Christopher Sparages, Sualyneth Galarza, Manu O. Platt, Arthur M. Mercurio, and Shelly R. Peyton

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Translating research into practice: Protocol for a community-engaged, stepped wedge randomized trial to reduce disparities in breast cancer treatment through a regional patient navigation collaborative, Tracy A. Battaglia, Karen M. Freund, Jennifer S. Haas, Nicole Casanova, Sharon Bak, Howard Cabral, Rachel A. Freedman, Karen Burns. White, and Stephenie C. Lemon

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Investigating Socioeconomic Disparities in the Potential Healthy Eating and Physical Activity Environments of Churches, John A. Bernhart, Elizabeth A. La Valley, Andrew T. Kaczynski, Sara Wilcox, Danielle E. Jake-Schoffman, Nathan Peters, Caroline G. Dunn, and Brent Hutto

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An Interactive Web-Based Lethal Means Safety Decision Aid for Suicidal Adults (Lock to Live): Pilot Randomized Controlled Trial, Marian E. Betz, Christopher E. Knoepke, Scott Simpson, Bonnie J. Siry, Ashley Clement, Tamara Saunders, Rachel Johnson, Deborah Azrael, Edwin D. Boudreaux, Faris Omeragic, Leah M. Adams, Sydney Almond, Elizabeth Juarez-Colunga, and Daniel D. Matlock

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Benefits and harms of high-dose haemodiafiltration versus high-flux haemodialysis: the comparison of high-dose haemodiafiltration with high-flux haemodialysis (CONVINCE) trial protocol, Peter J. Blankestijn, Kathrin I. Fischer, Claudia Barth, Krister Cromm, Bernard Canaud, Andrew Davenport, Diederick E. Grobbee, Jorgen Hegbrant, Kit C. Roes, Matthias S. F. Rose, Giovanni Fm. Strippoli, Robin Wm. Vernooij, Mark Woodward, G. Ardine de Wit de, and Michiel L. Bots

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mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis, Camila Martinez Calejman, S. Trefely, S. W. Entwisle, Amelia K. Luciano, Su Myung. Jung, Wen-Yu Hsiao, A. Torres, C. M. Hung, H. Li, N. W. Snyder, J. Villen, K. E. Wellen, and David A. Guertin

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Integrated miRNA-/mRNA-Seq of the Habenulo-Interpeduncular Circuit During Acute Nicotine Withdrawal, Alison P. Casserly, Junko Tsuji, Rubing Zhao-Shea, Ciearra B. Smith, Susanna Molas-Casacuberta, Andrew R. Tapper, Zhiping Weng, and Paul D. Gardner

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Combining Citizen Science and Genomics to Investigate Tick, Pathogen, and Commensal Microbiome at Single-Tick Resolution, Gaurav Chauhan, Jesse McClure, Jessica Hekman, Patrick W. Marsh, Jeffrey A. Bailey, Rachel F. Daniels, Diane P. Genereux, and Elinor K. Karlsson

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The Snakeskin-Mesh Complex of Smooth Septate Junction Restricts Yorkie to Regulate Intestinal Homeostasis in Drosophila, Hsi-Ju Chen, Qi Li, Niraj K. Nirala, and Y. Tony Ip

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Comparisons of Antibody Populations in Different Pre-Fusion F VLP-Immunized Cotton Rat Dams and Their Offspring, Lori McGinnes Cullen, Marina S. Boukhvalova, Jorge C. G. Blanco, and Trudy G. Morrison

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Mechanisms of insulin resistance related to white, beige, and brown adipocytes, Michael P. Czech

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Tacrolimus- and sirolimus-induced human beta cell dysfunction is reversible and preventable, Chunhua Dai, John T. Walker, Alena Shostak, Ana Padgett, Erick Spears, Scott Wisniewski, Greg Poffenberger, Radhika Aramandla, E Danielle. Dean, Nripesh Prasad, Shawn E. Levy, Dale L. Greiner, Leonard D. Shultz, Rita Bottino, and Alvin C. Powers

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Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca2+, and receptor binding, Dibyendu Kumar Das, Uriel Bulow, William E. Diehl, Natasha D. Durham, Fernando Senjobe, Kartik Chandran, Jeremy Luban, and James B. Munro

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Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors, Paul Dembny, Douglas T. Golenbock, and Seija Lehnardt

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Real-Time Analysis of Individual Ebola Virus Glycoproteins Reveals Pre-Fusion, Entry-Relevant Conformational Dynamics, Natasha D. Durham, Angela R. Howard, Ramesh Govindan, Fernando Senjobe, J. Maximilian Fels, William E. Diehl, Jeremy Luban, Kartik Chandran, and James B. Munro

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Dbf4-Dependent Kinase (DDK)-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A in Saccharomyces cerevisiae, Jessica R. Eisenstatt, Lars Boeckmann, Wei-Chun Au, Valerie Garcia, Levi Bursch, Josefina Ocampo, Michael Costanzo, Michael Weinreich, Robert A. Sclafani, Anastasia Baryshnikova, Chad L. Myers, Charles Boone, David J. Clark, Richard E. Baker, and Munira A. Basrai

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Diagnostic Category Prevalence in 3 Classification Systems Across the Transition to the International Classification of Diseases, Tenth Revision, Clinical Modification, Randall P. Ellis, Heather E. Hsu, Chenlu Song, Tzu-Chun Kuo, Bruno Martins, Jeffrey J. Siracuse, Ying Liu, and Arlene S. Ash

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A chromosomal connectome for psychiatric and metabolic risk variants in adult dopaminergic neurons, Sergio Espeso-Gil, Tyler M. Borrman, Zhiping Weng, and Schahram Akbarian

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Dopamine transporter trafficking and Rit2 GTPase: Mechanism of action and in vivo impact, Rita R. Fagan, Patrick Kearney, Carolyn G. Sweeney, Dino Luethi, Florianne E. Schoot Uiterkamp, Klaus Schicker, Brian S. Alejandro, Lauren C. O'Connor, Harald H. Sitte, and Haley Melikian

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Transcriptomics of Gabra4 knockout mice reveals common NMDAR pathways underlying autism, memory, and epilepsy, Cuixia Fan, Yue Gao, Guanmei Liang, Lang Huang, Jing Wang, Xiaoxue Yang, Yiwu Shi, Ursula C. Drager, Mei Zhong, Tian-Ming Gao, and Xinping Yang

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Comparison of a Collective Intelligence Tailored Messaging System on Smoking Cessation Between African American and White People Who Smoke: Quasi-Experimental Design, Jamie Faro, Catherine S. Nagawa, Jeroan J. Allison, Stephenie C. Lemon, Kathleen M. Mazor, Thomas K. Houston, and Rajani S. Sadasivam

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Diabetes mellitus type 2 is associated with increased tumor expression of programmed death-ligand 1 (PD-L1) in surgically resected non-small cell lung cancer - A matched case-control study, Christopher A. Febres-Aldana, Robert Poppiti, John M. Varlotto, Rick Voland, Michael Zaleski, Setareh Sharzehi, and Negar Rassaei

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Chronic recurrent priapism: A high flow state secondary to an arteriovenous fistula of the corpus cavernosum, Catherine M. Fiore, Melissa L. Pellegrino, and Meghna C. Trivedi

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Patient-reported outcomes feedback report for knee arthroplasty patients should present selective information in a simple design - findings of a qualitative study, Kathrin I. Fischer, Diarmuid De Faoite, and Matthias S. F. Rose

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Trajectories of Health-Related Quality of Life and HbA1c Values of Children and Adolescents With Diabetes Mellitus Type 1 Over 6 Months: A Longitudinal Observational Study, Kathrin I. Fischer, Felix H. Fischer, Dana Barthel, Christiane Otto, Ute Thyen, Marcus Klein, Otto Walter, Ulrike Ravens-Sieberer, Matthias S. F. Rose, and Sandra Nolte

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Comprehensive fitness maps of Hsp90 show widespread environmental dependence, Julia M. Flynn, Ammeret Rossouw, Pamela A. Cote-Hammarlof, Ines Fragata, David Mavor, Carl Hollins III, Claudia Bank, and Daniel N. Bolon

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Innate Immunity in the C. elegans Intestine Is Programmed by a Neuronal Regulator of AWC Olfactory Neuron Development, Kyle J. Foster, Hilary K. Cheesman, Pengpeng Liu, Nicholas D. Peterson, Sarah M. Anderson, and Read Pukkila-Worley

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Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency, Jonathan Frew, Fen-Biao Gao, and Haakon B. Nygaard

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beta-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia, Lea L. Friker, Hannah Scheiblich, Inga V. Hochheiser, Rebecca Brinkschulte, Dietmar Riedel, Eicke Latz, Matthias Geyer, and Michael T. Heneka

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Liver-Directed but Not Muscle-Directed AAV-Antibody Gene Transfer Limits Humoral Immune Responses in Rhesus Monkeys, Sebastian P. Fuchs, Jose M. Martinez-Navio, Eva G. Rakasz, Guangping Gao, and Ronald C. Desrosiers

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An Innovative Electronic Health Toolkit (Our Whole Lives for Chronic Pain) to Reduce Chronic Pain in Patients With Health Disparities: Open Clinical Trial, Paula Gardiner, Salvatore D'Amico, Man Luo, and Niina Haas

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Muscle-Directed Delivery of an AAV1 Vector Leads to Capsid-Specific T Cell Exhaustion in Nonhuman Primates and Humans, Gwladys Gernoux, Alisha M. Gruntman, Meghan Blackwood, Marina Zieger, Terence R. Flotte, and Christian Mueller

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A case report of recurrent spontaneous coronary artery dissection and Takotsubo cardiomyopathy: a treatment dilemma, Hafiz U. Ghafoor, Abhishek Bose, Amr El-Meligy, and Joseph Hannan

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Epstein-Barr Virus Epitope-Major Histocompatibility Complex Interaction Combined with Convergent Recombination Drives Selection of Diverse T Cell Receptor alpha and beta Repertoires, Anna Gil, Larisa Kamga, Ramakanth Chirravuri-Venkata, Nuray Aslan, Fransenio G. Clark, Dario Ghersi, Katherine Luzuriaga, and Liisa K. Selin

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LncRNA RP11-19E11 is an E2F1 target required for proliferation and survival of basal breast cancer, A. Giro-Perafita, L. Luo, A. Khodadadi-Jamayran, M. Thompson, Betul Akgol-Oksuz, A. Tsirigos, B. D. Dynlacht, I. Sanchez, and F. J. Esteva

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The Smoking Gun: Can We Do for Gun Control What We Are Doing to Control the Vaping and E-Cigarettes Epidemic?, Robert J. Goldberg, Kate L. Lapane, Stephenie C. Lemon, and Michael P. Hirsh

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Respiratory Rate Monitoring in Clinical Environments with a Contactless Ultra-Wideband Impulse Radar-based Sensor System, Charlotte E. Goldfine, Farhan Tasnim Oshim, Stephanie P. Carreiro, Brittany P. Chapman, Deepak Ganesan, and Tauhidur Rahman

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Regulation of adipose tissue inflammation by interleukin 6, Myoung Souk Han, Alexis White, Rachel J. Perry, Joao-Paulo Camporez, Juan Hidalgo, Gerald I. Shulman, and Roger J. Davis

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Co-Administration of Injected and Oral Vaccine Candidates Elicits Improved Immune Responses over Either Route Alone, Celine A. Hayden, Danilo Landrock, Chiung Yu Hung, Gary R. Ostroff, Gina M. Fake, John H. Walker, Ann Kier, and John A. Howard

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A thermophilic phage uses a small terminase protein with a fixed helix-turn-helix geometry, Janelle A. Hayes, Brendan J. Hilbert, Christl Gaubitz, Nicholas P. Stone, and Brian A. Kelch

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Cuffless Single-Site Photoplethysmography for Blood Pressure Monitoring, Manish Hosanee, Richard Fletcher, and Mohamed Elgendi

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Generating Medical Assessments Using a Neural Network Model: Algorithm Development and Validation, Baotian Hu, Adarsha Bajracharya, and Hong Yu

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NCAPG Dynamically Coordinates the Myogenesis of Fetal Bovine Tissue by Adjusting Chromatin Accessibility, Xin Hu, Yishen Xing, Xing Fu, Qiyuan Yang, Ling Ren, Yahui Wang, Qian Li, Junya Li, and Lupei Zhang

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Structure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein Cofactor, Simon Jenni, Louis-Marie Bloyet, Ruben Diaz-Avalos, Bo Liang, Sean P.J. Whelan, Nikolaus Grigorieff, and Stephen C. Harrison

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Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope, Tingting Jiang, Xiao-Ou Zhang, Yueying Cao, Zhiping Weng, and Wen Xue

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Expanding Point-of-Care Ultrasound Training in a Low- and Middle-Income Country: Experiences From a Collaborative Short-Training Workshop in Kenya, Leanne Jones, Catherine Gathu, Daria Szkwarko, Sam Mucheru, Naushad Amin, James A. Amisi, Kevin Bergman, Mena Ramos, and Neil Jayasekera

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Objective Measurement of Physician Stress in the Emergency Department Using a Wearable Sensor, Eric E. Kaczor, Stephanie P. Carreiro, Joshua Stapp, Brittany P. Chapman, and Premananda Indic

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Reducing Hospitalizations and Emergency Department Visits in Patients With Venous Thromboembolism Using a Multicomponent Care Transition Intervention, Alok Kapoor, Sarah Bloomstone, Saud Javed, Abiramy Maheswaran, Ahmed Nagy, Rasha Elhag, Diana Houng, Chad E. Darling, David D. McManus, Bruce A. Barton, and Kathleen M. Mazor

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Challenges and Lessons Learned From a Mobile Health, Web-Based Human Papillomavirus Intervention for Female Korean American College Students: Feasibility Experimental Study, Minjin Kim, Haeok Lee, and Jeroan J. Allison

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Psychiatric illness and regression in individuals with Phelan-McDermid syndrome, Teresa M. Kohlenberg, M. Pilar Trelles, Brittany McLarney, Catalina Betancur, Audrey Thurm, and Alexander Kolevzon

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STRIDE-a fluorescence method for direct, specific in situ detection of individual single- or double-strand DNA breaks in fixed cells, Magdalena M. Kordon, Miroslaw Zarebski, Kamil Solarczyk, Hanhui Ma, Thoru Pederson, and Jurek W. Dobrucki

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A Pilot Study of a Telemedicine-based Substance Use Disorder Evaluation to Enhance Access to Treatment Following Near-Fatal Opioid Overdose, Jeffrey T. Lai, Brittany P. Chapman, Stephanie P. Carreiro, Amy D. Costigan, Karla M. Rodriguez-Perez, Gerardo Gonzalez, and Kavita M. Babu

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The coordinate actions of calcineurin and Hog1 mediate the stress response through multiple nodes of the cell cycle network, Cassandra M. Leech, Mackenzie J. Flynn, Heather E. Arsenault, Jianhong Ou, Haibo Liu, Lihua Julie Zhu, and Jennifer A. Benanti

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Cultural Influences on Dietary Self-Management of Type 2 Diabetes in East Asian Americans: A Mixed-Methods Systematic Review, Tony Li-Geng, Jessica Kilham, and Katherine M. McLeod

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Identification and Characterization of the Lactating Mouse Mammary Gland Citrullinome, Guangyuan Li, Coleman H. Young, Bryce Snow, Amanda O. Christensen, M. Kristen Demoruelle, Venkatesh V. Nemmara, Paul R. Thompson, Heather M. Rothfuss, and Brian D. Cherrington

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Reporter Assays for Ebola Virus Nucleoprotein Oligomerization, Virion-Like Particle Budding, and Minigenome Activity Reveal the Importance of Nucleoprotein Amino Acid Position 111, Aaron E. Lin, William E. Diehl, Yingyun Cai, Courtney L. Finch, Chidiebere Akusobi, Robert N. Kirchdoerfer, Laura Bollinger, Stephen F. Schaffner, Elizabeth A. Brown, Erica Ollmann Saphire, Kristian G. Andersen, Jens H. Kuhn, Jeremy Luban, and Pardis C. Sabeti

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Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder, Hua Liu, Andrew W. Zimmerman, Kanwaljit Singh, Susan Connors, Eileen Diggins, Katherine K. Stephenson, Albena T. Dinkova-Kostova, and Jed W. Fahey

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Transcriptomic profiling reveals extraordinary diversity of venom peptides in unexplored predatory gastropods of the genus Clavus, Aiping Lu, Maren Watkins, Qing Li, Samuel D. Robinson, Gisela P. Concepcion, Mark Yandell, Zhiping Weng, Baldomero M. Olivera, Helena Safavi-Hemami, and Alexander E. Fedosov

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From aggressive to assertive, Mary E. Maloney and Patricia Moore

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Targeting Epigenetic Mechanisms to Alleviate Alcoholic Steatosis, Pranoti Mandrekar

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Real-world outcomes of long-term prednisone and deflazacort use in patients with Duchenne muscular dystrophy: experience at a single, large care center, Jessica R. Marden, Jonathan Freimark, Zhiwen Yao, James Signorovitch, Cuixia Tian, and Brenda L. Wong

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Hypertension and diabetes treatment affordability and government expenditures following changes in patient cost sharing in the "Farmacia popular" program in Brazil: an interrupted time series study, Isabel Cristina Martins Emmerick, Monica Rodrigues Campos, Rondineli Mendes. da Silva, Luisa Arueira Chaves, Andrea Damaso Bertoldi, Dennis Ross-Degnan, and Vera Lucia Luiza

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Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors, Ashley N. Matthew, Jacqueto Zephyr, Nageswara Rao Desaboini, Mina Henes, Wasih Kamran, Klajdi Kosovrasti, Adam Hedger, Gordon J. Lockbaum, Jennifer Timm, Akbar Ali, Nese Kurt Yilmaz, and Celia A. Schiffer

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A systematic re-examination of processing of MHCI-bound antigenic peptide precursors by ER aminopeptidase 1, George Mavridis, Richa Arya, Alexander Domnick, Jerome Zoidakis, Manousos Makridakis, Antonia Vlahou, Anastasia Mpakali, Angelos Lelis, Dimitris Georgiadis, Robert Tampe, Athanasios Papakyriakou, Lawrence J. Stern, and Efstratios Stratikos

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Loss of huntingtin function slows synaptic vesicle endocytosis in striatal neurons from the htt(Q140/Q140) mouse model of Huntington's disease, Robyn L. McAdam, Andrew Morton, Sarah L. Gordon, Julia F. Alterman, Anastasia Khvorova, Michael A. Cousin, and Karen J. Smillie

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Individual vs. Group Delivery of Acupuncture Therapy for Chronic Musculoskeletal Pain in Urban Primary Care-a Randomized Trial, M. Diane McKee, Arya Nielsen, Belinda Anderson, Elizabeth Chuang, Mariel Connolly, Qi Gao, Eric N. Gil, Claudia Lechuga, Mimi Kim, Huma Naqvi, and Benjamin Kligler

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Synthesis and applications of theranostic oligonucleotides carrying multiple fluorine atoms, Valeriy G. Metelev and Alexei A. Bogdanov

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Histone deacetylases 1 and 2 silence cryptic transcription to promote mitochondrial function during cardiogenesis, Zachary J. Milstone, Sherin Saheera, Lauren Bourke, Tomer Shpilka, Cole M. Haynes, and Chinmay M. Trivedi

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First Pass Effect in Patients Treated With the Trevo Stent-Retriever: A TRACK Registry Study Analysis, Maxim Mokin and Ajit S. Puri

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A curated benchmark of enhancer-gene interactions for evaluating enhancer-target gene prediction methods, Jill E. Moore, Henry E. Pratt, Michael J. Purcaro, and Zhiping Weng

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Association of smoking and right ventricular function in middle age: CARDIA study, Henrique T. Moreira, Anderson C. Armstrong, Chike C. Nwabuo, Henrique D. Vasconcellos, Andre Schmidt, Ravi K. Sharma, Bharath Ambale-Venkatesh, Mohammad R. Ostovaneh, Catarina I. Kiefe, Cora E. Lewis, Pamela J. Schreiner, Stephen Sidney, Kofo O. Ogunyankin, Samuel S. Gidding, and Joao A. C. Lima

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Global FKRP Registry: observations in more than 300 patients with Limb Girdle Muscular Dystrophy R9, Lindsay B. Murphy, John Herbert Stevenson, and Volker Straub

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Identifying unreliable predictions in clinical risk models, Paul D. Myers, Kenney Ng, Kristen Severson, Uri Kartoun, Wangzhi Dai, Wei Huang, Frederick A. Anderson Jr., and Collin M. Stultz

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The validation of organisational culture assessment instrument in healthcare setting: results from a cross-sectional study in Vietnam, Huy Nguyen, Nguyen Thi Hoai Thu, Nguyen Le Tuan Anh, Nguyen Thanh Hai Au, Nguyen The Phuong, Nguyen Thi Cham, and Pham Duc Minh

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Interpretation of the Epigenetic Signature of Facioscapulohumeral Muscular Dystrophy in Light of Genotype-Phenotype Studies, Ana Nikolic, Louise Maranda, and Rossella Ginevra Tupler

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Proteomic and Transcriptional Profiles of Human Stem Cell-Derived beta Cells Following Enteroviral Challenge, Julius O. Nyalwidhe, Agata Jurczyk, Basanthi Satish, Sambra D. Redick, Natasha Qaisar, Melanie I. Trombly, Pranitha Vangala, Riccardo Racicot, Rita Bortell, David M. Harlan, Dale L. Greiner, Michael A. Brehm, Jerry L. Nadler, and Jennifer P. Wang

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TRIM34 restricts HIV-1 and SIV capsids in a TRIM5alpha-dependent manner, Molly Ohainle, Kyusik Kim, Sevnur Komurlu Keceli, Abby Felton, Ed Campbell, Jeremy Luban, and Michael Emerman

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JC Virus infected choroid plexus epithelial cells produce extracellular vesicles that infect glial cells independently of the virus attachment receptor, Bethany A. O'Hara, Jenna Morris-Love, Gretchen V. Gee, Sheila A. Haley, and Walter J. Atwood

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CK2-Dependent Phosphorylation of the Brg1 Chromatin Remodeling Enzyme Occurs during Mitosis, Teresita Padilla-Benavides, Dominic T. Haokip, Yeonsoo Yoon, Pablo Reyes-Gutierrez, Jaime A. Rivera, and Anthony N. Imbalzano

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Adaptive Evolution Targets a piRNA Precursor Transcription Network, Swapnil Parhad, Tianxiong Yu, Gen Zhang, Nicholas P. Rice, Zhiping Weng, and William E. Theurkauf

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Association of Childhood Psychosocial Environment With 30-Year Cardiovascular Disease Incidence and Mortality in Middle Age, Jacob B. Pierce, Kiarri N. Kershaw, Catarina I. Kiefe, David R. Jacobs Jr., Stephen Sidney, Sharon Stein. Merkin, and Joe Feinglass

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Medialized Total Ossicular Replacement Prosthesis, Marc D. Polanik and Aaron K. Remenschneider

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Utilization of ACP CPT codes among high-need Medicare beneficiaries in 2017: A brief report, Amanda J. Reich, Ginger Jin, Avni Gupta, Dae Kim, Stuart Lipstiz, Holly G. Prigerson, Jennifer Tjia, Keren Ladin, Scott D. Halpern, Zara Cooper, and Joel S. Weissman

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HIF-1 Has a Central Role in Caenorhabditis elegans Organismal Response to Selenium, Laura Romanelli-Credrez, Maria Doitsidou, Mark J. Alkema, and Gustavo Salinas

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Learning Latent Space Representations to Predict Patient Outcomes: Model Development and Validation, Subendhu Rongali, Adam J. Rose, David D. McManus, Adarsha Bajracharya, Alok Kapoor, Edgard A. Granillo, and Hong Yu

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Physician Anxiety and Burnout: Symptom Correlates and a Prospective Pilot Study of App-Delivered Mindfulness Training, Alexandra Roy, Susan Druker, Elizabeth A. Hoge, and Judson A. Brewer

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Evaluation of pre-processing on the meta-analysis of DNA methylation data from the Illumina HumanMethylation450 BeadChip platform, Claudia Sala, Pietro Di Lena, Danielle Fernandes Durso, Andrea Prodi, Gastone Castellani, and Christine Nardini

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Evaluation of pre-processing on the meta-analysis of DNA methylation data from the Illumina HumanMethylation450 BeadChip platform, Claudia Sala, Pietro Di Lena, Danielle Fernandes Durso, Andrea Prodi, Gastone Castellani, and Christine Nardini

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Does DNA Methylation Matter in FSHD, Valentina Salsi, Frederique Magdinier, and Rossella Ginevra Tupler

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Rates of Potentially Inappropriate Dosing of Direct-Acting Oral Anticoagulants and Associations With Geriatric Conditions Among Older Patients With Atrial Fibrillation: The SAGE-AF Study, Saket Sanghai, Cecillia Wong, Ziyue Wang, Pia Clive, Wenisa Tran, Molly Waring, Robert J. Goldberg, Robert Hayward, Jane S. Saczynski, and David D. McManus

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Data on enrichment of chitosan nanoparticles for intranasal delivery of oligonucleotides to the brain, Vasyl Sava, Oksana Fihurka, Anastasia Khvorova, and Juan Sanchez-Ramos

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A re-evaluation of silk measurement by the cecropia caterpillar (Hyalophora cecropia) during cocoon construction reveals use of a silk odometer that is temporally regulated, Hana Sehadova, Patrick A. Guerra, Ivo Sauman, and Steven M. Reppert

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Are dietary fish oil supplements appropriate for dyslipidemia management? A review of the evidence, Samuel C. R. Sherratt, Michael Lero, and R. Preston Mason

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Developmental regression and mitochondrial function in children with autism, Kanwaljit Singh, Indrapal N. Singh, Eileen Diggins, Susan Connors, Mohammad A. Karim, David Lee, Andrew W. Zimmerman, and Richard E. Frye

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Adenine base editing in an adult mouse model of tyrosinaemia, Chun-Qing Song, Tingting Jiang, Michelle Richter, Luke H. Rhym, Luke W. Koblan, Maria Paz Zafra, Emma M. Schatoff, Jordan L. Doman, Yueying Cao, Lukas E. Dow, Lihua Julie Zhu, Daniel G. Anderson, David R. Liu, Hao Yin, and Wen Xue