Open Access is free, unrestricted, online access to scientific and scholarly research. This collection includes Open Access journal articles authored by researchers, faculty, staff, and students of the University of Massachusetts Medical School.

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Publications from 2017

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Defining the 5 and 3 landscape of the Drosophila transcriptome with Exo-seq and RNaseH-seq, Shaked Afik, Osnat Bartok, Maxim N. Artyomov, Alexander A. Shishkin, Sabah Kadri, Mor Hanan, Xiaopeng Zhu, Manuel Garber, and Sebastian Kadener

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Adeno-associated virus serotype rh.10 displays strong muscle tropism following intraperitoneal delivery, Jianzhong Ai, Jia Li, Dominic J. Gessler, Qin Su, Qiang Wei, Hong Li, and Guangping Gao

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Risks of PEG tube placement in patients with cirrhosis-associated ascites, Yasir Al-Abboodi, Ali Ridha, Matthew J. Fasullo, and Tarek H. Naguib

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Dermatologist and Patient Preferences in Choosing Treatments for Moderate to Severe Psoriasis, Matthew Alcusky, Seina Lee, Gordon Lau, Gretchen R. Chiu, Nandini Hadker, Aparna Deshpande, Stephen Fleming, Nicola Vance, and Steve Fakharzadeh

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Evaluation of the impact of a prescribing guideline on the use of intraoperative dexmedetomidine at a tertiary academic medical center, Abdullah M. Alhammad, Nour A. Baghdady, Rachel A. Mullin, and Bonnie C. Greenwood

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A High-throughput Assay for mRNA Silencing in Primary Cortical Neurons in vitro with Oligonucleotide Therapeutics, Julia F. Alterman, Andrew H. Coles, Lauren M. Hall, Neil Aronin, Anastasia Khvorova, and Marie C. Didiot

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Staying afloat in a sea of information: Point-of-care resources, Rebecca Andrews, Neil Mehta, Jack Maypole, and Stephen A. Martin

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Interpreting T-Cell Cross-reactivity through Structure: Implications for TCR-Based Cancer Immunotherapy, Dinler A. Antunes, Mauricio M. Rigo, Martiela V. Freitas, Marcus F. A. Mendes, Marialva Sinigaglia, Gregory Lizee, Lydia E. Kavraki, Liisa K. Selin, Markus Cornberg, and Gustavo F. Vieira

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FLT1 and transcriptome-wide polyadenylation site (PAS) analysis in preeclampsia, Ami Ashar-Patel, Yasin Kaymaz, Augustine Rajakumar, Jeffrey A. Bailey, S. Ananth Karumanchi, and Melissa J. Moore

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Lacunar-canalicular network in femoral cortical bone is reduced in aged women and is predominantly due to a loss of canalicular porosity, A. M. Ashique, L. S. Hart, C. D. L. Thomas, J. G. Clement, P. Pivonka, Yasmin Carter, D. D. Mousseau, and D. M. L. Cooper

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Severity of Acute Infectious Mononucleosis Correlates with Cross-Reactive Influenza CD8 T-Cell Receptor Repertoires, Nuray Aslan, Levi B. Watkin, Anna Gil, Rabinarayan Mishra, Fransenio G. Clark, Raymond M. Welsh, Dario Ghersi, Katherine Luzuriaga, and Liisa K. Selin

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Nucleosomes influence multiple steps during replication initiation, Ishara F. Azmi, Shinya Watanabe, Michael F. Maloney, Sukhyun Kang, Jason A. Belsky, David M. MacAlpine, Craig L. Peterson, and Stephen P. Bell

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A National CERA Study of the Use of Laborists in Family Medicine Residency Training, Robert A. Baldor, Christine Chang Pecci, Gerardo Moreno, Virginia Van Duyne, and Stacy E. Potts

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Local neuropeptide signaling modulates serotonergic transmission to shape the temporal organization of C. elegans egg-laying behavior, Navonil Banerjee, Raja Bhattacharya, Michael Gorczyca, Kevin M. Collins, and Michael M. Francis

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BALB/c mice immunized with a combination of virus-like particles incorporating Kaposi sarcoma-associated herpesvirus (KSHV) envelope glycoproteins gpK8.1, gB, and gH/gL induced comparable serum neutralizing antibody activity to UV-inactivated KSHV, Anne K. Barasa, Peng Ye, Meredith Phelps, Ganapathiram T. Arivudainambi, Timelia Tison, and Javier Gordon Ogembo

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Excitatory neurons sculpt GABAergic neuronal connectivity in the C. elegans motor circuit, Belinda Barbagallo, Alison Philbrook, Denis Touroutine, Navonil Banerjee, Devyn Oliver, Christopher M. Lambert, and Michael M. Francis

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Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality, David Beauparlant, Peter Rusert, Carsten Magnus, Claus Kadelka, Jacqueline Weber, Therese Uhr, Osvaldo Zagordi, Corinna Oberle, Maria J. Duenas-Decamp, Paul R. Clapham, Karin J. Metzner, Huldrych F. Gunthard, and Alexandra Trkola

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A Circulating microRNA Signature Predicts Age-Based Development of Lymphoma, Afshin Beheshti, Charles Vanderburg, J. Tyson McDonald, Charusheila Ramkumar, Tatenda Kadungure, Hong Zhang, Ronald B. Gartenhaus, and Andrew M. Evens

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HMGB1, IL-1alpha, IL-33 and S100 proteins: dual-function alarmins, Damien Bertheloot and Eicke Latz

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Functional Requirements for Heparan Sulfate Biosynthesis in Morphogenesis and Nervous System Development in C. elegans, Cassandra R. Blanchette, Andrea Thackeray, Paola N. Perrat, Siegfried Hekimi, and Claire Y. Benard

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Virtual Patient Technology: Engaging Primary Care in Quality Improvement Innovations, Amanda C. Blok, Christine N. May, Rajani S. Sadasivam, and Thomas K. Houston

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The Availability and Utility of Services to Address Risk Factors for Recidivism among Justice-Involved Veterans, Daniel M. Blonigen, Allison L. Rodriguez, Luisa Manfredi, Jessica Britt, Andrea Nevedal, Andrea K. Finlay, Joel Rosenthal, David A. Smelson, and Christine Timko

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The Trypanosome Exocyst: A Conserved Structure Revealing a New Role in Endocytosis, Cordula M. Boehm, Samson Obado, Catarina Gadelha, Alexandra Kaupisch, Paul T. Manna, Gwyn W. Gould, Mary Munson, Brian T. Chait, Michael P. Rout, and Mark C. Field

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"The Impact of Mycobacterium tuberculosis Immune Evasion on Protective Immunity: Implications for TB Vaccine Design" - Meeting report, Cesar Boggiano, Katrin Eichelberg, Lakshmi Ramachandra, Jaqueline Shea, Lalita Ramakrishnan, Samuel M. Behar, Joel D. Ernst, Steven A. Porcelli, Markus Maeurer, and Hardy Kornfeld

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Enteroaggregative Escherichia coli Adherence Fimbriae Drive Inflammatory Cell Recruitment via Interactions with Epithelial MUC1, Erik J. Boll, Jorge Ayala-Lujan, Rose L. Szabady, Christopher Louissaint, Rachel Z. Smith, Karen A. Krogfelt, James P. Nataro, Fernando Ruiz-Perez, and Beth A. McCormick

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Krill Oil-In-Water Emulsion Protects against Lipopolysaccharide-Induced Proinflammatory Activation of Macrophages In Vitro, Gabriel A. Bonaterra, David F. Driscoll, Hans Schwarzbach, and Ralf Kinscherf

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A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival, Elias Bou Samra, Geraldine Buhagiar-Labarchede, Christelle Machon, Jerome Guitton, Rosine Onclercq-Delic, Michael R. Green, Olivier Alibert, Claude Gazin, Xavier Veaute, and Mounira Amor-Gueret

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A systems level approach to temporal expression dynamics in Drosophila reveals clusters of long term memory genes, Julianna Bozler, Balint Z. Kacsoh, Hao Chen, William E. Theurkauf, Zhiping Weng, and Giovanni Bosco

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Soluble Uric Acid Activates the NLRP3 Inflammasome, Tarcio Teodoro Braga, Maria Fernanda Forni, Matheus Correa-Costa, Rodrigo Nalio Ramos, Jose Alexandre Barbuto, Paola Branco, Angela Castoldi, Meire Ioshie Hiyane, Mariana Rodrigues Davanso, Eicke Latz, Bernardo S. Franklin, Alicia J. Kowaltowski, and Niels Olsen Saraiva Camara

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A Pilot Study of the Effects of Mindfulness-Based Stress Reduction on Post-traumatic Stress Disorder Symptoms and Brain Response to Traumatic Reminders of Combat in Operation Enduring Freedom/Operation Iraqi Freedom Combat Veterans with Post-traumatic Stress Disorder, James Douglas Bremner, Sanskriti Mishra, Carolina Campanella, Majid Shah, Nicole Kasher, Sarah Evans, Negar Fani, Amit Jasvant Shah, Collin Reiff, Lori L. Davis, Viola Vaccarino, and James F. Carmody

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Characterization of a new oda3 allele, oda3-6, defective in assembly of the outer dynein arm-docking complex in Chlamydomonas reinhardtii, Jason M. Brown, Matthew Mosley, Daniela Montes-Berrueta, Yuqing Hou, Fan Yang, Chasity Scarbrough, George B. Witman, and Maureen Wirschell

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IFT trains in different stages of assembly queue at the ciliary base for consecutive release into the cilium, Jason M. Brown, Tyler Picariello, Deborah A. Cochran, George B. Witman, and Karl Lechtreck

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Fifteen years of research on oral-facial-digital syndromes: from 1 to 16 causal genes, Ange-Line Bruel, Thibaut Eguether, Gregory J. Pazour, and Christel Thauvin-Robinet

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Donor Diabetes and Prolonged Cold Ischemia Time Synergistically Increase the Risk of Graft Failure After Liver Transplantation, Isabel M. A. Bruggenwirth, Natasha H. Dolgin, Robert J. Porte, Adel Bozorgzadeh, and Paulo N.A. Martins

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Tocilizumab combination therapy or monotherapy or methotrexate monotherapy in methotrexate-naive patients with early rheumatoid arthritis: 2-year clinical and radiographic results from the randomised, placebo-controlled FUNCTION trial, Gerd R. Burmester, William F. Rigby, Ronald F. van Vollenhoven, Jonathan Kay, Andrea Rubbert-Roth, Ricardo Blanco, Alysha Kadva, and Sophie Dimonaco

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Behavioral activation for smoking cessation and mood management following a cardiac event: results of a pilot randomized controlled trial, Andrew Busch, Erin M. Tooley, Shira Dunsiger, Elizabeth A. Chattillion, John Fani Srour, Sherry L. Pagoto, Christopher W. Kahler, and Belinda Borrelli

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Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis, Carmelo Carmona-Rivera, Paul R. Thompson, and Mariana J. Kaplan

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Vaccine-elicited memory CD4+ T cell expansion is impaired in the lungs during tuberculosis, Stephen M. Carpenter, Jason D. Yang, Jinhee Lee, Palmira Barreira-Silva, and Samuel M. Behar

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Randomized Controlled Study of a Remote Flipped Classroom Neuro-otology Curriculum, Frederick Robert Carrick, Mahera Abdulrahman, Ahmed Hankir, Maksim Zayaruzny, Kinda Najem, Palita Lungchukiet, and Roger A. Edwards

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Race, Ethnicity, Income Concentration and 10-Year Change in Urban Greenness in the United States, Joan A. Casey, Peter James, Lara Cushing, William M. Jesdale, and Rachel Morello-Frosch

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Lowering relative humidity level increases epidermal protein deimination and drives human filaggrin breakdown, Laura Cau, Valerie Pendaries, Emeline Lhuillier, Paul R. Thompson, Guy Serre, Hidenari Takahara, Marie-Claire Mechin, and Michel Simon

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Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue, Carly T. Cederquist, Claudia Lentucci, Camila Martinez Calejman, Vanessa Hayashi, Joseph Orofino, David A. Guertin, Susan K. Fried, Mi-Jeong Lee, M. Dafne Cardamone, and Valentina Perissi

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High-resolution profiling of NMD targets in yeast reveals translational fidelity as a basis for substrate selection, Alper Celik, Richard E. Baker, Feng He, and Allan Jacobson

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NMD monitors translational fidelity 24/7, Alper Celik, Feng He, and Allan Jacobson

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A common class of transcripts with 5'-intron depletion, distinct early coding sequence features, and N1-methyladenosine modification, Can Cenik, Hon Nian Chua, Guramrit Singh, Abdalla Akef, Michael P. Snyder, Alexander F. Palazzo, Melissa J. Moore, and Frederick P. Roth

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Augmenting the anisotropic network model with torsional potentials improves PATH performance, enabling detailed comparison with experimental rate data, Srinivas Niranj Chandrasekaran and Charles W. Carter Jr

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An SMC-like protein binds and regulates Caenorhabditis elegans condensins, Lucy Fang-I Chao, Meha Singh, James Thompson, John R. Yates 3rd, and Kirsten A. Hagstrom

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Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis, Catherine Y. Cheng, Nuria M. Martinez, Kim West, Hardy Kornfeld, and Amit Singhal

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Cdc6 contributes to abrogating the G1 checkpoint under hypoxic conditions in HPV E7 expressing cells, Hanxiang Chen, Qishu Zhang, Lijun Qiao, Xueli Fan, Weifang Zhang, Weiming Zhao, and Jason J. Chen

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HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans, Huan-Da Chen, Raffi V. Aroian, and Chang-Shi Chen

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Ranking Medical Terms to Support Expansion of Lay Language Resources for Patient Comprehension of Electronic Health Record Notes: Adapted Distant Supervision Approach, Jinying Chen, Abhyuday N. Jagannatha, Samah J. Fodeh, and Hong Yu

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The prevalence and risk factors of preterm small-for-gestational-age infants: a population-based retrospective cohort study in rural Chinese population, Shi Chen, Rong Zhu, Huijuan Zhu, Hongbo Yang, Fengying Gong, Linjie Wang, Yu Jiang, Bill Q. Lian, Chengsheng Yan, Jianqiang Li, Qing Wang, Shi-Kun Zhang, and Hui Pan

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Access to Guideline-Recommended Pharmacogenomic Tests for Cancer Treatments: Experience of Providers and Patients, Ann Chen Wu, Kathleen M. Mazor, Rachel Ceccarelli, Stephanie Loomer, and Christine Y. Lu

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Glycolytic reliance promotes anabolism in photoreceptors, Yashodhan Chinchore, Tedi Begaj, David Wu, Eugene Drokhlyansky, and Constance L. Cepko

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Establishing a Research Agenda for Understanding the Role and Impact of Mental Health Peer Specialists, Matthew Chinman, D. Keith. McInnes, Susan Eisen, Marsha Langer Ellison, Marianne Farkas, Moe Armstrong, and Sandra G. Resnick

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Reducing therapeutic misconception: A randomized intervention trial in hypothetical clinical trials, Paul P. Christopher, Paul S. Appelbaum, Debbie Truong, Karen Albert, Louise S. Maranda, and Charles W. Lidz

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JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21, B. Colleoni, S. Paternot, J. M. Pita, X. Bisteau, K. Coulonval, Roger J. Davis, E. Raspe, and P. P. Roger

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The 2016 Model of the Clinical Practice of Emergency Medicine, Francis L. Counselman, Kavita Babu, Mary Ann. Edens, Diane L. Gorgas, Cherri Hobgood, Catherine A. Marco, Eric Katz, Kevin Rodgers, Leonard A. Stallings, Michael C. Wadman, Michael S. Beeson, Julia N. Keehbauch, and American Board of Emergency Medicine

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XIST RNA: a window into the broader role of RNA in nuclear chromosome architecture, Kevin Creamer and Jeanne B. Lawrence

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The importance of RSV F protein conformation in VLPs in stimulation of neutralizing antibody titers in mice previously infected with RSV, Lori M. Cullen, Madelyn R. Schmidt, and Trudy G. Morrison

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A Cross-Sectional Study of Dietary and Genetic Predictors of Blood Folate Levels in Healthy Young Adults, Daniel Cummings, Kevin F. Dowling, Noah J. Silverstein, Alexandra S. Tanner, Hamdi Eryilmaz, Jordan W. Smoller, and Joshua L. Roffman

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Age-dependent human beta cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling, Chunhua Dai, Yan Hang, Alena Shostak, Greg Poffenberger, Nathaniel Hart, Nripesh Prasad, Neil Phillips, Shawn E. Levy, Dale L. Greiner, Leonard D. Shultz, Rita Bottino, Seung K. Kim, and Alvin C. Powers

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Long-Term Effects of G-CSF Therapy in Cyclic Neutropenia, David C. Dale, AudreyAnna Bolyard, Tracy Marrero, Vahagn Makaryan, MaryAnn Bonilla, Daniel C. Link, Peter E. Newburger, Akiko Shimamura, Laurence A. Boxer, and Charles Spiekerman

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Multiple fixed drug eruption to minocycline at sites of healed burn and zoster: An interesting case of locus minoris resistentiae, Renata Dalla Costa, Connie Yihan Yang, Molly Stout, Daniela Kroshinsky, and Arianne Shadi Kourosh

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Effect of transcription factor resource sharing on gene expression noise, Dipjyoti Das, Supravat Dey, Robert C. Brewster, and Sandeep Choubey (PLoS computational biology, 2017-04-17)

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Melanoma mystery, Roger J. Davis

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Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis, Michael A. DeJesus, Elias R. Gerrick, Weizhen Xu, Sae Woong. Park, Jarukit E. Long, Cara C. Boutte, Eric J. Rubin, Dirk Schnappinger, Sabine Ehrt, Sarah M. Fortune, Christopher M. Sassetti, and Thomas R. Ioerger

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Statistical analysis of genetic interactions in Tn-Seq data, Michael A. DeJesus, Subhalaxmi Nambi, Clare M. Smith, Richard E. Baker, Christopher M. Sassetti, and Thomas R. Ioerger

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Structure of RNA polymerase bound to ribosomal 30S subunit, Gabriel Demo, Aviram Rasouly, Nikita Vasilyev, Vladimir Svetlov, Anna B. Loveland, Ruben Diaz-Avalos, Nikolaus Grigorieff, Evgeny Nudler, and Andrei A. Korostelev

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Mechanism of ribosome rescue by ArfA and RF2, Gabriel Demo, Egor Svidritskiy, Rohini Madireddy, Ruben Diaz-Avalos, Timothy Grant, Nikolaus Grigorieff, Duncan Sousa, and Andrei A. Korostelev

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Diagnostic performance and optimal cut-off scores of the Massachusetts youth screening instrument-second version in a sample of Swiss youths in welfare and juvenile justice institutions, Claudia Dolitzsch, Laura E. W. Leenarts, Klaus Schmeck, Jorg M. Fegert, Thomas Grisso, and Marc Schmid

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Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates, Joshua C. Doloff, Dale L. Greiner, and Daniel G. Anderson

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Evidence of potential bias in a comparison of beta blockers and calcium channel blockers in patients with chronic obstructive pulmonary disease and acute coronary syndrome: results of a multinational study, Yaa-Hui Dong, Matthew Alcusky, Vittorio Maio, Jun Liu, Mengdan Liu, Li-Chiu Wu, Chia-Hsuin Chang, Mei-Shu Lai, and Joshua J. Gagne

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Methicillin-resistant Staphylococcus aureus in acute otitis externa, Maria J. Duarte, Elliott D. Kozin, Paulo J. M. Bispo, Andreas H. Mitchell, Michael S. Gilmore, and Aaron K. Remenschneider

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NOTCH3 regulates stem-to-mural cell differentiation in infantile hemangioma, Andrew K. Edwards, Kyle Glithero, Peter Grzesik, Alison A. Kitajewski, Naikhoba C.O. Munabi, Krista Hardy, Qian Kun Tan, Michael Schonning, Thaned Kangsamaksin, Jan K. Kitajewski, Carrie J. Shawber, and June K. Wu

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An Embryonic Stem Cell-Specific NuRD Complex Functions through Interaction with WDR5, Ly-Sha Ee, Kurtis N. McCannell, Yang Tang, Nancy Fernandes, W. Rod Hardy, Michael R. Green, Feixia Chu, and Thomas G. Fazzio

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Clinical application of a cancer genomic profiling assay to guide precision medicine decisions, Cheryl Eifert, Angeliki Pantazi, Ruobai Sun, Jia Xu, Pablo Cingolani, Joerg Heyer, Meaghan Russell, Maria Lvova, Jennifer Ring, Julie Y. Tse, Stephen Lyle, and Alexei Protopopov

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A systematic review and meta-analysis on herpes zoster and the risk of cardiac and cerebrovascular events, Nathaniel Erskine, Hoang Tran, Len L. Levin, Christine M. Ulbricht, Joyce D. Fingeroth, Catarina I. Kiefe, Robert J. Goldberg, and Sonal Singh

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A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD, Rustam Esanov, Gabriela Toro Cabrera, Nadja S. Andrade, Tania F. Gendron, Robert H. Brown Jr., Michael Benatar, Claes Wahlestedt, Christian Mueller, and Zane Zeier

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Teens, Tweets, and Tanning Beds: Rethinking the Use of Social Media for Skin Cancer Prevention, Ashley E. Falzone, Claire D. Brindis, Mary-Margaret Chren, Alexandra Junn, Sherry L. Pagoto, Mackenzie Wehner, and Eleni Linos

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The dynamics of immunoglobulin V-gene usage and clonotype expansion in mice after prime and boost immunizations as analyzed by NGS, Diego José Farfán Arribas, Shuying Liu, Shixia Wang, and Shan Lu

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Microscopic Colitis After Fecal Microbiota Transplant, Matthew J. Fasullo, Yasir Al-Azzawi, and Jeffrey Abergel

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LFA-1 Mediates Cytotoxicity and Tissue Migration of Specific CD8(+) T Cells after Heterologous Prime-Boost Vaccination against Trypanosoma cruzi Infection, Camila Pontes Ferreira, Leonardo Moro. Cariste, Fernando Dos. Santos Virgilio, Barbara Ferri Moraschi, Caroline Brandao. Monteiro, Alexandre M. Vieira Machado, Ricardo T. Gazzinelli, Oscar Bruna-Romero, Pedro Luiz. Menin Ruiz, Daniel Araki Ribeiro, Joseli Lannes-Vieira, Marcela de Freitas Lopes, Mauricio Martins Rodrigues, and Jose Ronnie. de Vasconcelos Carvalho

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Activation of Inflammatory and Pro-Thrombotic Pathways in Acute Stress Cardiomyopathy, Timothy P. Fitzgibbons, Yvonne J. K. Edwards, Peter Shaw, Aline Iskandar, Mohamed Ahmed, Josiah T. Bote, Tejen Shah, Sumita Sinha, Robert E. Gerszten, John F. Keaney Jr., Michael R. Zile, and Gerard P. Aurigemma

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Killers creating new life: caspases drive apoptosis-induced proliferation in tissue repair and disease, Caitlin E. Fogarty and Andreas Bergmann

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Systemic administration of an HIV-1 broadly neutralizing dimeric IgA yields mucosal secretory IgA and virus neutralization, G. G. Fouda, J. Eudailey, E. L. Kunz, J. D. Amos, B. E. Liebl, J. Himes, F. Boakye-Agyeman, K. Beck, Anthony J. Michaels, M. Cohen-Wolkowiez, B. F. Haynes, Keith A. Reimann, and S. R. Permar

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Important patient characteristics differ prior to total knee arthroplasty and total hip arthroplasty between Switzerland and the United States, Patricia D. Franklin, Hermes Miozzari, Panayiotis Christofilopoulos, Pierre Hoffmeyer, David C. Ayers, and Anne Lubbeke

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alpha-Gal Nanoparticles in Wound and Burn Healing Acceleration, Uri Galili

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A paradigm shift for socioeconomic justice and health: from focusing on inequalities to aiming at sustainable equity, Juan E. Garay and David E. Chiriboga

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Attaching-and-Effacing Pathogens Exploit Junction Regulatory Activities of N-WASP and SNX9 to Disrupt the Intestinal Barrier, John J. Garber, Emily M. Mallick, Karen M. Scanlon, Jerrold R. Turner, Michael S. Donnenberg, John M. Leong, and Scott B. Snapper

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Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis, Jiefei Geng, Yasushi Ito, Linyu Shi, Palak Amin, Jiachen Chu, Amanda Tomie Ouchida, Adnan Kasim Mookhtiar, Heng Zhao, Daichao Xu, Bing Shan, Ayaz Najafov, Guangping Gao, Shizuo Akira, and Junying Yuan

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Autoreactive helper T cells alleviate the need for intrinsic TLR signaling in autoreactive B cell activation, Josephine R. Giles, Adriana Turqueti Neves, Ann Marshak-Rothstein, and Mark J. Shlomchik

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Clostridium difficile in Inflammatory Bowel Disease: A Retrospective Study, William Gillespie, Neil Marya, Julien Fahed, Gregory Leslie, Krunal Patel, and David R. Cave

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Systemic gene delivery transduces the enteric nervous system of guinea pigs and cynomolgus macaques, S. E. Gombash, C. J. Cowley, J. A. Fitzgerald, C. A. Lepak, M. G. Neides, K. Hook, L. J. Todd, G-D Wang, Christian Mueller, B. K. Kaspar, E. C. Bielefeld, A. J. Fischer, J. D. Wood, and K. D. Foust

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Protocol for analyzing protein ensemble structures from chemical cross-links using DynaXL, Zhou Gong, Zhu Liu, Xu Dong, Yue-He Ding, Meng-Qiu Dong, and Chun Tang

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Lipidomic Evaluation of Feline Neurologic Disease after AAV Gene Therapy, Heather L. Gray-Edwards, Xuntian Jiang, Ashley N. Randle, Amanda R. Taylor, Taylor L. Voss, Aime K. Johnson, Victoria J. McCurdy, Miguel Sena-Esteves, Daniel S. Ory, and Douglas R. Martin

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Mutational re-modeling of di-aspartyl intramembrane proteases: uncoupling physiologically-relevant activities from those associated with Alzheimer's disease, Anastasia P. Grigorenko, Youri K. Moliaka, Olga V. Plotnikova, Alexander Smirnov, Vera A. Nikishina, Andrey Y. Goltsov, Fedor Gusev, Tatiana V. Andreeva, Omar Nelson, Ilya Bezprozvanny, and Evgeny I. Rogaev

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Central Role of IL-23 and IL-17 Producing Eosinophils as Immunomodulatory Effector Cells in Acute Pulmonary Aspergillosis and Allergic Asthma, Evelyn V. Santos Guerra, Chrono K. Lee, Charles A. Specht, Bhawna Yadav, Haibin Huang, Ali Akalin, Jun R. Huh, Christian Mueller, and Stuart M. Levitz

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Dimorphic cocoons of the cecropia moth (Hyalophora cecropia): Morphological, behavioral, and biophysical differences, Patrick A. Guerra and Steven M. Reppert

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Intracranial AAV-IFN-beta gene therapy eliminates invasive xenograft glioblastoma and improves survival in orthotopic syngeneic murine model, Dwijit Guhasarkar, James Neiswender, Qin Su, Guangping Gao, and Miguel Sena-Esteves