Open Access is free, unrestricted, online access to scientific and scholarly research. This collection includes Open Access journal articles authored by researchers, faculty, staff, and students of the University of Massachusetts Medical School.

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Publications from 2018

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Under one roof: identification, evaluation, and treatment of chronic hepatitis C in addiction care, Stephen A. Martin, Jordon Bosse, Amanda Wilson, Phyllis Losikoff, and Lisa Chiodo

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A parental requirement for dual-specificity phosphatase 6 in zebrafish, Jennifer M. Maurer and Charles G. Sagerstrom

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Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance, David Mavor, Daniel N. Bolon, Martin Kampmann, and James S. Fraser

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RNA binding proteins co-localize with small tau inclusions in tauopathy, Brandon F. Maziuk, Daniel J. Apicco, Anna Lourdes Cruz, Lulu Jiang, Peter E. A. Ash, Edroaldo Lummertz. da Rocha, Cheng Zhang, Wai Haung Yu, John D. Leszyk, Jose F. Abisambra, Hu Li, and Benjamin Wolozin

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Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines, Sean M. McCauley, Kyusik Kim, Anetta Nowosielska, Ann Dauphin, Leonid Yurkovetskiy, William E. Diehl, and Jeremy Luban

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Deaf and Hard-of-Hearing Learners in Emergency Medicine, Lisa M. Meeks, Alina Engelman, Alicia Booth, and Michael Argenyi

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Primary Cardiac Lymphoma: Importance of Tissue Diagnosis, Lauren Mendelson, Emily Hsu, Hojune Chung, and Andrew Hsu

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Identification of a Novel Invasion-Promoting Region in Insulin Receptor Substrate 2, Jose Mercado-Matos, Jenny Janusis, Sha Zhu, Samuel S. Chen, and Leslie M. Shaw

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Facilitating HIV/AIDS and HIV testing literacy for emergency department patients: a randomized, controlled, trial, Roland C. Merchant, Tao Liu, Melissa A. Clark, and Michael P. Carey

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Code Help: Can This Unique State Regulatory Intervention Improve Emergency Department Crowding?, Sean S. Michael, John Broach, Kevin A. Kotkowski, David Eric Brush, Gregory A. Volturo, and Martin A. Reznek

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Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing, Aamir Mir, Julia F. Alterman, Matthew R. Hassler, Alexandre J. Debacker, Edward Hudgens, Dimas Echeverria, Michael H. Brodsky, Anastasia Khvorova, Jonathan K. Watts, and Erik J. Sontheimer

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Extracellular vesicles in oral squamous carcinoma carry oncogenic miRNA profile and reprogram monocytes via NF-kappaB pathway, Fatemeh Momen-Heravi and Shashi Bala

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JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial Memory, Caroline Morel, Tessi Sherrin, Norman J. Kennedy, Kelly H. Forest, Seda Barutcu, Michael Robles, Ezekiel Carpenter-Hyland, Naghum Alfulaij, Claire L. Standen, Robert A. Nichols, Morris Benveniste, Roger J. Davis, and Cedomir Todorovic

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The Three-Fold Axis of the HIV-1 Capsid Lattice Is the Species-Specific Binding Interface for TRIM5alpha, Damien Morger, Franziska Zosel, Martin Buhlmann, Sara Zuger, Maximilian Mittelviefhaus, Benjamin Schuler, Jeremy Luban, and Markus G. Grutter

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Donated chemical probes for open science, Susanne Muller, Paul R. Thompson, and Anke Mueller-Fahrnow

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Clinical Relation Extraction Toward Drug Safety Surveillance Using Electronic Health Record Narratives: Classical Learning Versus Deep Learning, Tsendsuren Munkhdalai, Feifan Liu, and Hong Yu

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ORBIT: a New Paradigm for Genetic Engineering of Mycobacterial Chromosomes, Kenan C. Murphy, Samantha J. Nelson, Subhalaxmi Nambi, Kadamba Papavinasasundaram, Christina E. Baer, and Christopher M. Sassetti

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MYC amplification in subtypes of breast cancers in African American women, Tammey J. Naab, Anita Gautam, Luisel Ricks-Santi, Ashwini K. Esnakula, Yasmine M. Kanaan, Robert L. DeWitty, Girmay Asgedom, Khepher H. Makambi, Massih Abawi, and Jan K. Blancato

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Morphine versus fentanyl patient-controlled analgesia for postoperative pain control in major hepatic resection surgeries including living liver donors: A retrospective study, Eman M. Nada and Abdulmajeed Alabdulkareem

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HLA-DO modulates the diversity of the MHC-II self-peptidome, Padma P. Nanaware, Mollie M. Jurewicz, John D. Leszyk, Scott A. Shaffer, and Lawrence J. Stern

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The NF-kappaB Factor Relish Regulates Atg1 Expression and Controls Autophagy, Anubhab Nandy, Lin Lin, Panagiotis D. Velentzas, Louisa P. Wu, Eric H. Baehrecke, and Neal S. Silverman

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Health Information Discrepancies Between Internet Media and Scientific Papers Reporting on Omega-3 Supplement Research: Comparative Analysis, Daryl Nault, Ariel Beccia, Haruka Ito, Sarah Kashdan, and Angela Senders

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The N-terminal region of photocleavable peptides that bind HLA-DR1 determines the kinetics of fragment release, Maria P. Negroni and Lawrence J. Stern

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Resting state functional connectivity in patients with remitted psychotic depression: A multi-centre STOP-PD study, Nicholas H. Neufeld, Benoit H. Mulsant, Erin W. Dickie, Barnett S. Meyers, George S. Alexopoulos, Anthony J. Rothschild, Ellen M. Whyte, Matthew J. Hoptman, Arash Nazeri, Jonathan Downar, Alastair J. Flint, and Aristotle N. Voineskos

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Culturally adaptive storytelling intervention versus didactic intervention to improve hypertension control in Vietnam- 12 month follow up results: A cluster randomized controlled feasibility trial, Hoa L. Nguyen, Duc A. Ha, Robert J. Goldberg, Catarina I. Kiefe, German Chiriboga, Ha N. Ly, Cuong K. Nguyen, Ngoc T. Phan, Nguyen C. Vu, Quang P. Nguyen, and Jeroan J. Allison

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Transcriptome Analysis of Neisseria gonorrhoeae during Natural Infection Reveals Differential Expression of Antibiotic Resistance Determinants between Men and Women, Kathleen Nudel, Ryan McClure, Matthew Moreau, Emma Briars, A. Jeanine Abrams, Brian Tjaden, Xiao-Hong Su, David Trees, Peter A. Rice, Paola Massari, and Caroline A. Genco

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Tobacco smoke exposure is an independent predictor of vitamin D deficiency in US children, Benjamin U. Nwosu and Philip Kum-Nji

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Children with type 1 diabetes who experienced a honeymoon phase had significantly lower LDL cholesterol 5 years after diagnosis, Benjamin U. Nwosu, Bo Zhang, Sanaa S. Ayyoub, Stephanie Choi, Tony R. Villalobos-Ortiz, Laura C. Alonso, and Bruce A. Barton

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N-terminal Sumoylation of Centromeric Histone H3 Variant Cse4 Regulates Its Proteolysis To Prevent Mislocalization to Non-centromeric Chromatin, Kentaro Ohkuni, Reuben Levy-Myers, Jack Warren, Wei-Chun Au, Yoshimitsu Takahashi, Richard E. Baker, and Munira A. Basrai

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SUMO-Targeted Ubiquitin Ligases (STUbLs) Reduce the Toxicity and Abnormal Transcriptional Activity Associated With a Mutant, Aggregation-Prone Fragment of Huntingtin, Kentaro Ohkuni, Nagesh Pasupala, Jennifer Peek, Grace Lauren Holloway, Gloria D. Sclar, Reuben Levy-Myers, Richard E. Baker, Munira A. Basrai, and Oliver Kerscher

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Red wine and green tea flavonoids are cis-allosteric activators and competitive inhibitors of GLUT1-mediated sugar uptake, Ogooluwa A. Ojelabi, Kenneth P. Lloyd, Julie K. De Zutter, and Anthony Carruthers

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Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming, David Olagnier, Mona Motwani, Katherine A. Fitzgerald, and Christian K. Holm

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Signaling Pathways Induced by Leptin during Epithelial(-)Mesenchymal Transition in Breast Cancer, Monserrat Olea-Flores, Juan Carlos Juarez-Cruz, Miguel A. Mendoza-Catalan, Teresita Padilla-Benavides, and Napoleon Navarro-Tito

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Tolerating the Unwelcome Guest; How the Host Withstands Persistent Mycobacterium tuberculosis, Andrew J. Olive and Christopher M. Sassetti

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Molecular Mechanisms Directing Spine Outgrowth and Synaptic Partner Selection in Caenorhabditis elegans, Devyn Oliver, Kellianne Alexander, and Michael M. Francis

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Pilot Study of Delayed ICOS/ICOS-L Blockade With alphaCD40 to Modulate Pathogenic Alloimmunity in a Primate Cardiac Allograft Model, Natalie A. O'Neill, Tianshu Zhang, Gheorghe Braileanu, Xiangfei Cheng, Alena Hershfeld, Wenji Sun, Keith A. Reimann, Sia Dahi, Natalia Kubicki, Wessam Hassanein, Christopher Laird, Arielle Cimeno, Agnes M. Azimzadeh, and Richard N. Pierson

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ATACseqQC: a Bioconductor package for post-alignment quality assessment of ATAC-seq data, Jianhong Ou, Haibo Liu, Jun Yu, Michelle A. Kelliher, Lucio H. Castilla, Nathan D. Lawson, and Lihua Julie Zhu

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Inefficient Metabolism of the Human Milk Oligosaccharides Lacto-N-tetraose and Lacto-N-neotetraose Shifts Bifidobacterium longum subsp. infantis Physiology, Ezgi Ozcan and David Sela

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Using the Habit App for Weight Loss Problem Solving: Development and Feasibility Study, Sherry Pagoto, Bengisu Tulu, Emmanuel Agu, Molly E. Waring, Jessica L. Oleski, and Danielle E. Jake-Schoffman

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Numerous recursive sites contribute to accuracy of splicing in long introns in flies, Athma A. Pai, Joseph M. Paggi, Paul Yan, Karen Adelman, and Christopher B. Burge

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A comparative analysis of preservation techniques for the optimal molecular detection of hookworm DNA in a human fecal specimen, Marina Papaiakovou, Nils Pilotte, Ben Baumer, Jessica Grant, Kristjana Asbjornsdottir, Fabian Schaer, Yan Hu, Raffi V. Aroian, Judd Walson, and Steven A. Williams

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Delayed Treatment Acceleration in Patients with Rheumatoid Arthritis Who Have Inadequate Response to Initial Tumor Necrosis Factor Inhibitors: Data from the Corrona Registry, Dimitrios A. Pappas, Robert A. Gerber, Heather J. Litman, David Gruben, Jamie Geier, Winnie D. Hua, Connie Chen, YouFu Li, Joel M. Kremer, John S. Andrews, and Jeffrey A. Bourret

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Effects of reproductive period duration and number of pregnancies on midlife ECG indices: a secondary analysis from the Women's Health Initiative Clinical Trial, Nisha I. Parikh, Kristopher Kapphahn, Haley Hedlin, Jeffrey E. Olgin, Matthew A. Allison, Jared W. Magnani, Kelli R. Ryckman, Molly E. Waring, Marco Valentin Perez, and Barbara V. Howard

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Use of structural equation models to predict dengue illness phenotype, Sangshin Park, Anon Srikiatkhachorn, Siripen Kalayanarooj, Louis Macareo, Sharone Green, Jennifer F. Friedman, and Alan L. Rothman

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Differential expression of zinc transporters accompanies the differentiation of C2C12 myoblasts, Amanda L. Paskavitz, Julia Quintana, Daniella Cangussu, Cristina Tavera-Montanez, Yao Xiao, Sonia Ortiz-Mirnada, Juan G. Navea, and Teresita Padilla-Benavides

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Opposing Roles of FANCJ and HLTF Protect Forks and Restrain Replication during Stress, Min Peng, Ke Cong, Nicholas J. Panzarino, Sumeet Nayak, Jennifer Calvo, Bin Deng, Lihua Julie Zhu, Monika Morocz, Lili Hegedus, Lajos Haracska, and Sharon B. Cantor

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The LRRK2 Variant E193K Prevents Mitochondrial Fission Upon MPP+ Treatment by Altering LRRK2 Binding to DRP1, Maria Perez Carrion, John E. Landers, Stefano Goldwurm, and Giovanni Piccoli

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Aerobic Glycolysis Is Essential for Normal Rod Function and Controls Secondary Cone Death in Retinitis Pigmentosa, Lolita Petit, Shan Ma, Joris Cipi, Shun-Yun Cheng, Marina Zieger, Nissim Hay, and Claudio Punzo

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Widespread presentation and spontaneous regression of porokeratotic eccrine ostial and dermal duct nevus, Stephanie Petkiewicz, Julia Baltz, Kristine M. Cornejo, April C. Deng, and Karen Wiss

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Neurexin directs partner-specific synaptic connectivity in C. elegans, Alison Philbrook, Shankar Ramachandran, Christopher M. Lambert, Devyn Oliver, Jeremy Florman, Mark J. Alkema, Michele Lemons, and Michael M. Francis

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Dynamics of human protein kinase Aurora A linked to drug selectivity, Warintra Pitsawong, Vanessa Buosi, Renee Otten, Roman V. Agafonov, Adelajda Zorba, Nadja Kern, Steffen Kutter, Gunther Kern, Ricardo Ap Padua, Xavier Meniche, and Dorothee Kern

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Application of area scaling analysis to identify natural killer cell and monocyte involvement in the GranToxiLux antibody dependent cell-mediated cytotoxicity assay, Justin Pollara, Chiara Orlandi, Charles Beck, R Whitney Edwards, Yi Hu, Shuying Liu, Shixia Wang, Richard A. Koup, Thomas N. Denny, Shan Lu, Georgia D. Tomaras, Anthony DeVico, George K. Lewis, and Guido Ferrari

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Effects of Age, Race, and Ethnicity on the Optic Nerve and Peripapillary Region Using Spectral-Domain OCT 3D Volume Scans, Linda Yi-Chieh Poon, Hussein Antar, Edem Tsikata, Rong Guo, Georgia Papadogeorgou, Madeline Freeman, Ziad Khoueir, Ramon Lee, Eric Shieh, Huseyin Simavli, Christian John Que, Johannes F. de Boer, and Teresa C. Chen

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Ras hyperactivation versus overexpression: Lessons from Ras dynamics in Candida albicans, Vavilala A. Pratyusha, Guiliana Soraya Victoria, Mohammad Firoz Khan, Dominic T. Haokip, Bhawna Yadav, Nibedita Pal, Subhash Chandra Sethi, Priyanka Jain, Sneh Lata Singh, Sobhan Sen, and Sneha Sudha Komath

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Development and validation of a new MRI simulation technique that can reliably estimate optimal in vivo scanning parameters in a glioblastoma murine model, Andrea Protti, Kristen L. Jones, Dennis M. Bonal, Lei Qin, Letterio S. Politi, Sasha Kravets, Quang-De Nguyen, and Annick D. Van den Abbeele

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Preleukemia and Leukemia-Initiating Cell Activity in inv(16) Acute Myeloid Leukemia, John A. Pulikkan and Lucio H. Castilla

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Implementing universal Lynch syndrome screening (IMPULSS): protocol for a multi-site study to identify strategies to implement, adapt, and sustain genomic medicine programs in different organizational contexts, Alanna Kulchak Rahm and Mara M. Epstein

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Tuberculosis and lung damage: from epidemiology to pathophysiology, Shruthi Ravimohan, Hardy Kornfeld, Drew Weissman, and Gregory P. Bisson

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Using support vector machines on photoplethysmographic signals to discriminate between hypovolemia and euvolemia, Natasa Reljin, Gary Zimmer, Yelena Malyuta, Kirk Shelley, Yitzhak Mendelson, David J. Blehar, Chad E. Darling, and Ki H. Chon

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Resistant gonorrhoea: east meets west, Peter A. Rice and Xiao-Hong Su

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Drosophila Ror is a nervous system-specific co-receptor for Wnt ligands, Caroline Ripp, Julia Loth, Iveta Petrova, Karen Linnemannstons, Monique Ulepic, Lee G. Fradkin, Jasprien Noordermeer, and Andreas Wodarz

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Modulation of CaV1.3b L-type calcium channels by M1 muscarinic receptors varies with CaVbeta subunit expression, Mandy L. Roberts-Crowley and Ann R. Rittenhouse

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Comparison of prescribing practices for older adults treated by female versus male physicians: A retrospective cohort study, Paula A. Rochon and Jerry H. Gurwitz

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Epidemiological findings of major chemical attacks in the Syrian war are consistent with civilian targeting: a short report, Jose M. Rodriguez-Llanes, Debarati Guha-Sapir, Benjamin-Samuel Schluter, and Madelyn J. Hsiao-Rei Hicks

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PD-L1 is expressed on human platelets and is affected by immune checkpoint therapy, Verena Rolfes, Christian Idel, Ralph Pries, Kirstin Plotze-Martin, Jens Habermann, Timo Gemoll, Sabine Bohnet, Eicke Latz, Julika Ribbat-Idel, Bernardo S. Franklin, and Barbara Wollenberg

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Multi-ethnic genome-wide association study for atrial fibrillation, Carolina Roselli, Nada Esa, David D. McManus, Kahraman Tanriverdi, and Patrick T. Ellinor

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The Canady Helios Cold Plasma Scalpel Significantly Decreases Viability in Malignant Solid Tumor Cells in a Dose-Dependent Manner, Warren Rowe, Xiaoqian Cheng, Lawan Ly, Taisen Zhuang, Giacomo Basadonna, Barry Trink, Michael Keidar, and Jerome Canady

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Improving efficiency in neuroimaging research through application of Lean principles, Alexandra Roy, Julia Colpitts, Kara Becker, Judson A. Brewer, and Remko van Lutterveld

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A hybrid Neural Network Model for Joint Prediction of Presence and Period Assertions of Medical Events in Clinical Notes, Li Rumeng, Jagannatha Abhyuday, and Hong Yu

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On the Demographic and Selective Forces Shaping Patterns of Human Cytomegalovirus Variation within Hosts, Andrew M. Sackman, Susanne P. Pfeifer, Timothy F. Kowalik, and Jeffrey D. Jensen

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Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks, Olga V. Saik, Pavel S. Demenkov, Timofey V. Ivanisenko, Elena Yu. Bragina, Maxim B. Freidin, Irina A. Goncharova, Victor E. Dosenko, Olga I. Zolotareva, Ralf Hofestaedt, Inna N. Lavrik, Evgeny I. Rogaev, and Vladimir A. Ivanisenko

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Posttranslational modification of a histone-like protein regulates phenotypic resistance to isoniazid in mycobacteria, Alexandra Sakatos, Gregory H. Babunovic, Michael R. Chase, Alexander Dills, John D. Leszyk, Tracy Rosebrock, Bryan Bryson, and Sarah M. Fortune

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Immunohistochemical expression and prognostic value of PD-L1 in Extrapulmonary small cell carcinoma: a single institution experience, Mohammed Salhab, Yazan Migdady, Melanie Donahue, Yiqin Xiong, Karen A. Dresser, William Walsh, Benjamin J. Chen, and James Liebmann

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Stakeholder Engagement in Developing an Electronic Clinical Support Tool for Tobacco Prevention in Adolescent Primary Care, Ramzi G. Salloum, Ryan P. Theis, Lori Pbert, Matthew J. Gurka, Maribeth Porter, Diana Lee, Elizabeth A. Shenkman, and Lindsay A. Thompson

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Integrating mindfulness training in school health education to promote healthy behaviors in adolescents: Feasibility and preliminary effects on exercise and dietary habits, Elena Salmoirago-Blotcher, Susan Druker, Christine F. Frisard, Shira I. Dunsiger, Sybil L. Crawford, Florence Meleo-Meyer, Beth Bock, and Lori Pbert

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IMP3 Stabilization of WNT5B mRNA Facilitates TAZ Activation in Breast Cancer, Sanjoy Samanta, Santosh Guru, Ameer L. Elaimy, John J. Amante, Jianhong Ou, Jun Yu, Lihua Julie Zhu, and Arthur M. Mercurio

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Automated Diagnosis and Grading of Diabetic Retinopathy Using Optical Coherence Tomography, Harpal Singh. Sandhu, Ahmed Eltanboly, Ahmed Shalaby, Robert S. Keynton, Schlomit Schaal, and Ayman El-Baz

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Indexed Left Atrial Adipose Tissue Area Is Associated With Severity of Atrial Fibrillation and Atrial Fibrillation Recurrence Among Patients Undergoing Catheter Ablation, Saket R. Sanghai, Mayank Sardana, Barinder Hansra, Darleen M. Lessard, Seth T. Dahlberg, Gerard P. Aurigemma, Timothy P. Fitzgibbons, and David D. McManus

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Impact of Concurrent Genomic Alterations Detected by Comprehensive Genomic Sequencing on Clinical Outcomes in East-Asian Patients with EGFR-Mutated Lung Adenocarcinoma, Seijiro Sato, Stephen Lyle, Toshifumi Wakai, and Masanori Tsuchida

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A Qualitative Analysis of Patients' Perceptions of Shared Decision Making in the Emergency Department: "Let Me Know I Have a Choice", Elizabeth M. Schoenfeld, Sarah L. Goff, Gwendolyn Downs, Robert J. Wenger, Peter K. Lindenauer, and Kathleen M. Mazor

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Periostin antisense oligonucleotide suppresses bleomycin-induced formation of a lung premetastatic niche for melanoma, Takashi Semba, Eiji Sugihara, Nagisa Kamoshita, Sayaka Ueno, Keitaro Fukuda, Masafumi Yoshino, Kazumasa Takao, Kazunori Yoshikawa, Kenji Izuhara, Yoshimi Arima, Makoto Suzuki, and Hideyuki Saya

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Common and Dissociable Neural Activity After Mindfulness-Based Stress Reduction and Relaxation Response Programs, Gunes Sevinc, Britta K. Holzel, Javeria Hashmi, Jonathan Greenberg, Adrienne McCallister, Michael Treadway, Marissa L. Schneider, Jeffery A. Dusek, James F. Carmody, and Sara W. Lazar

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CRISPR-delivery particles targeting nuclear receptor-interacting protein 1 (Nrip1) in adipose cells to enhance energy expenditure, Yuefei Shen, Jessica L. Cohen, Sarah M. Nicoloro, Mark Kelly, Batuhan Yenilmez, Felipe Henriques, Emmanouela Tsagkaraki, Yvonne J. K. Edwards, Xiaodi Hu, Randall H. Friedline, Jason K. Kim, and Michael P. Czech

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A recombinant herpesviral vector containing a near-full-length SIVmac239 genome produces SIV particles and elicits immune responses to all nine SIV gene products, Young C. Shin, Georg F. Bischof, William A. Lauer, Lucas Gonzalez-Nieto, Eva G. Rakasz, Gregory M. Hendricks, David I. Watkins, Mauricio A. Martins, and Ronald C. Desrosiers

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Functional features defining the efficacy of cholesterol-conjugated, self-deliverable, chemically modified siRNAs, Taisia Shmushkovich, Kathryn R. Monopoli, Diana Homsy, Dmitriy Leyfer, Monica Betancur-Boissel, Anastasia Khvorova, and Alexey D. Wolfson

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Fever of Unknown Origin: Could It Be a Pheochromocytoma? A Case Report and Review of the Literature, Uzma Mohammad Siddiqui, Stephany Matta, Mireya Wessolossky, and Richard Haas

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Adapting a Behavioral Weight Loss Intervention for Delivery via Facebook: A Pilot Series Among Low-Income Postpartum Women, Valerie J. Silfee, Andrea Lopez-Cepero, Stephenie C. Lemon, Barbara Estabrook, Oanh Nguyen, Monica L. Wang, and Milagros C. Rosal

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An Update of Oral Health Curricula in US Family Medicine Residency Programs, Hugh Silk, Judith A. Savageau, Kate Sullivan, Gail Sawosik, and Min Wang

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Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions, Tania V. Silvas, Shurong Hou, Wazo Myint, Ellen A. Nalivaika, Mohan Somasundaran, Brian A. Kelch, Hiroshi Matsuo, Nese Kurt Yilmaz, and Celia A. Schiffer

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Membrane protein nanoparticles: the shape of things to come, Kailene S. Simon, Naomi L. Pollock, and Sarah C. Lee

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Prevalence and characteristics of sleep-disordered breathing in familial dysautonomia, Kanwaljit Singh, Jose-Alberto Palma, Horacio Kaufmann, Nataliya Tkachenko, Lucy Norcliffe-Kaufmann, Christy Spalink, Mikhail Kazachkov, and Sanjeev V. Kothare

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An evidence-based co-occurring disorder intervention in VA homeless programs: outcomes from a hybrid III trial, David A. Smelson, Matthew Chinman, Gordon Hannah, Thomas Byrne, and Sharon McCarthy

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Understanding and repurposing CRISPR-mediated alternative splicing, Jordan L. Smith, Haiwei Mou, and Wen Xue

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IL-16/miR-125a axis controls neutrophil recruitment in pristane-induced lung inflammation, Siobhan Smith, Hardy Kornfeld, and Caroline A. Jefferies

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Generation and characterization of monoclonal antibodies that recognize human and murine supervillin protein isoforms, Tara C. Smith, Richard G. Saul, Elisabeth R. Barton, and Elizabeth J. Luna

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Case Definitions for Conditions Identified by Newborn Screening Public Health Surveillance, Marci K. Sontag, Deboshree Sarkar, Anne Marie Comeau, Kathryn Hassell, Lorenzo D. Botto, Richard Parad, Susan R. Rose, Kupper A. Wintergerst, Kim Smith-Whitley, Sikha Singh, Careema Yusuf, Jelili Ojodu, Sara Copeland, and Cynthia F. Hinton

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What are the physical and psychological health effects of suicide bereavement on family members? An observational and interview mixed-methods study in Ireland, Ailbhe Spillane, Karen Matvienko-Sikar, Celine Larkin, Paul Corcoran, and Ella Arensman

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Systematic pan-cancer analysis of somatic allele frequency, Liam Spurr, Muzi Li, Nawaf Alomran, Qianqian Zhang, Paula Restrepo, Mercedeh Movassagh, Chris Trenkov, Nerissa Tunnessen, Tatiyana Apanasovich, Keith A. Crandall, Nathan Edwards, and Anelia Horvath

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Lifetime risk of atrial fibrillation according to optimal, borderline, or elevated levels of risk factors: cohort study based on longitudinal data from the Framingham Heart Study, Laila Staerk, Biqi Wang, Sarah R. Preis, Martin G. Larson, Steven A. Lubitz, Patrick T. Ellinor, David D. McManus, Darae Ko, Lu-Chen Weng, Kathryn L. Lunetta, Lars Frost, Emelia J. Benjamin, and Ludovic Trinquart

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Editorial: Nucleic Acids Research and Nucleic Acid Therapeutics, Barry L. Stoddard, Anastasia Khvorova, David R. Corey, William S. Dynan, and Keith R. Fox