Open Access is free, unrestricted, online access to scientific and scholarly research. This collection includes Open Access journal articles authored by researchers, faculty, staff, and students of the University of Massachusetts Medical School.

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Publications from 2019

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Assessment of Physician Well-being, Part Two: Beyond Burnout, Michelle D. Lall, Theodore J. Gaeta, Arlene S. Chung, Sneha A. Chinai, Manish Garg, Abbas Hussain, Cara Kanter, Sorabh Khandelwal, Caitlin S. Rublee, Ramin R. Tabatabai, James Kimo Takayesu, Mohammad Zaher, and Nadine T. Himelfarb

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Improving Electronic Health Record Note Comprehension With NoteAid: Randomized Trial of Electronic Health Record Note Comprehension Interventions With Crowdsourced Workers, John P. Lalor, Beverly Woolf, and Hong Yu

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Chitosan Biosynthesis and Virulence in the Human Fungal Pathogen Cryptococcus gattii, Woei C. Lam, Rajendra Upadhya, Charles A. Specht, Abigail E. Ragsdale, Camaron R. Hole, Stuart M. Levitz, and Jennifer K. Lodge

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Evolution of the exclusively human pathogen Neisseria gonorrhoeae: Human-specific engagement of immunoregulatory Siglecs, Corinna S. Landig, Ashley Hazel, Benjamin P. Kellman, Jerry J. Fong, Flavio Schwarz, Sarika Agarwal, Nissi Varki, Paola Massari, Nathan E. Lewis, Sanjay Ram, and Ajit Varki

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Important Role of the GLP-1 Axis for Glucose Homeostasis after Bariatric Surgery, Pierre Larraufie, Geoffrey P. Roberts, Anne K. McGavigan, Richard G. Kay, Joyce H. Li, Andrew B. Leiter, Audrey Melvin, Emma K. Biggs, Peter Ravn, Kathleen Davy, David C. Hornigold, Giles S. Yeo H, Richard H. Hardwick, Frank Reimann, and Fiona M. Gribble

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Human GLB1 knockout cerebral organoids: A model system for testing AAV9-mediated GLB1 gene therapy for reducing GM1 ganglioside storage in GM1 gangliosidosis, Yvonne L. Latour, Robin Yoon, Sarah E. Thomas, Christina Grant, Cuiling Li, Miguel Sena-Esteves, Maria L. Allende, Richard L. Proia, and Cynthia J. Tifft

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Which Should Be Used First for ALK-Positive Non-Small-Cell Lung Cancer: Chemotherapy or Targeted Therapy? A Meta-Analysis of Five Randomized Trials, Yen-Chien Lee, Chung-Cheng Hsieh, Yen-Ling Lee, and Chung-Yi Li

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Entosis Controls a Developmental Cell Clearance in C. elegans, Yongchan Lee, Jens C. Hamann, Mark Pellegrino, Joanne Durgan, Marie-Charlotte Domart, Lucy M. Collinson, Cole M. Haynes, Oliver Florey, and Michael Overholtzer

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Electrical impedance myography for reducing sample size in Duchenne muscular dystrophy trials, Melanie L. Leitner, Kush Kapur, Basil T. Darras, Michele Yang, Brenda Wong, Laura Dalle Pazze, Julaine Florence, Martin Buck, Laura Freedman, Jose Bohorquez, Seward Rutkove, and Craig Zaidman

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A unified encyclopedia of human functional DNA elements through fully automated annotation of 164 human cell types, Maxwell W. Libbrecht, Oscar L. Rodriguez, Zhiping Weng, Jeffrey A. Bilmes, Michael M. Hoffman, and William Stafford Noble

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The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact Formation, Dongfang Li, Yan G. Zhao, Di Li, Hongyu Zhao, Jie Huang, Guangyan Miao, Du Feng, Pingsheng Liu, Dong Li, and Hong Zhang

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Establishing the European Norm for the health-related quality of life domains of the computer-adaptive test EORTC CAT Core, G. Liegl, M. A. Petersen, M. Groenvold, N. K. Aaronson, A. Costantini, P. M. Fayers, B. Holzner, C. D. Johnson, G. Kemmler, K. A. Tomaszewski, A. Waldmann, T. E. Young, Matthias S. F. Rose, and S. Nolte

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Fine-Tuning Bidirectional Encoder Representations From Transformers (BERT)-Based Models on Large-Scale Electronic Health Record Notes: An Empirical Study, Fei Li, Yonghao Jin, Weisong Liu, Bhanu Pratap Rawat Singh, Pengshan Cai, and Hong Yu

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Inhibiting PAD2 enhances the anti-tumor effect of docetaxel in tamoxifen-resistant breast cancer cells, Fujun Li, Lixia Miao, Teng Xue, Hao Qin, Santanu Mondal, Paul R. Thompson, Scott A. Coonrod, Xiaoqiu Liu, and Xuesen Zhang

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YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression, Huapeng Li, Qi Li, Kyvan Dang, Shan Ma, Jennifer L. Cotton, Sun Yang, Lihua Julie Zhu, April C. Deng, Y. Tony Ip, Randy L. Johnson, Xu Wu, Claudio Punzo, and Junhao Mao

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Intestinal Neurod1 expression impairs paneth cell differentiation and promotes enteroendocrine lineage specification, Joyce H. Li, Subir Ray, Ning Pan, Jody Haigh, Bernd Fritzsch, and Andrew B. Leiter

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Structural but Not Functional Alterations in Cones in the Absence of the Retinal Disease Protein Retinitis Pigmentosa 2 (RP2) in a Cone-Only Retina, Linjing Li, Kollu N. Rao, and Hemant Khanna

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Immunosuppressive treatment and the risk of diabetes in rheumatoid arthritis, Siri Lillegraven, Jeffrey D. Greenberg, George W. Reed, Katherine Saunders, Jeffrey R. Curtis, Leslie R. Harrold, Marc C. Hochberg, Dimitrios A. Pappas, Joel M. Kremer, and Daniel H. Solomon

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Closing the Research-To-Practice Gap in Digital Psychiatry: The Need to Integrate Implementation Science, Jessica Lipschitz, Timothy P. Hogan, Mark S. Bauer, and David C. Mohr

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Adoption of Mobile Apps for Depression and Anxiety: Cross-Sectional Survey Study on Patient Interest and Barriers to Engagement, Jessica Lipschitz, Christopher J. Miller, Timothy P. Hogan, Katherine E. Burdick, Rachel Lippin-Foster, Steven R. Simon, and James Burgess

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Detection of Bleeding Events in Electronic Health Record Notes Using Convolutional Neural Network Models Enhanced With Recurrent Neural Network Autoencoders: Deep Learning Approach, Rumeng Li, Baotian Hu, Feifan Liu, Weisong Liu, Francesca Cunningham, David D. McManus, and Hong Yu

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Optimization of ribosome profiling using low-input brain tissue from fragile X syndrome model mice, Botao Liu, Gemma Molinaro, Huan Shu, Emily E. Stackpole, Kimberly M. Huber, and Joel D. Richter

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JNK(1/2) represses Lkb(1)-deficiency-induced lung squamous cell carcinoma progression, Jian Liu, Tianyuan Wang, Chad J. Creighton, San-Pin Wu, Madhumita Ray, Kyathanahalli S. Janardhan, Cynthia J. Willson, Sung-Nam Cho, Patricia D. Castro, Michael M. Ittmann, Jian-Liang Li, Roger J. Davis, and Francesco J. DeMayo

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Plasma Phospholipid Fatty Acids and Coronary Heart Disease Risk: A Matched Case-Control Study within the Women's Health Initiative Observational Study, Qing Liu, Nirupa R. Matthan, JoAnn E. Manson, Barbara V. Howard, Lesley F. Tinker, Marian L. Neuhouser, Linda V. Van Horn, Jacques E. Rossouw, Matthew A. Allison, Lisa W. Martin, Wenjun Li, Linda G. Snetselaar, Lu Wang, Alice H. Lichtenstein, and Charles B. Eaton

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Dysfunction in Serotonergic and Noradrenergic Systems and Somatic Symptoms in Psychiatric Disorders, Yi Liu, Jingping Zhao, Xiaoduo Fan, and Wenbin Guo

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Potential use of leukocytosis and anion gap elevation in differentiating psychogenic nonepileptic seizures from epileptic seizures, Yi Li, Liesl Matzka, Julie Flahive, and Daniel Weber

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Estimated stroke risk, yield, and number needed to screen for atrial fibrillation detected through single time screening: a multicountry patient-level meta-analysis of 141,220 screened individuals, Nicole Lowres, David D. McManus, and Apurv Soni

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Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons, Van B. Lu, Juraj Rievaj, Elisabeth A. O'Flaherty, Christopher A. Smith, Ramona Pais, Luke A. Pattison, Gwen Tolhurst, Andrew B. Leiter, David C. Bulmer, Fiona M. Gribble, and Frank Reimann

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Laryngeal mucous membrane plasmacytosis with 15 year follow-up: Case report and literature review, Vladislav V. Makarenko, Alec E. Vaezi, Doreen B. Brettler, Lloyd Hutchinson, Bruce A. Woda, and Benjamin J. Chen

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Genome analysis identifies the mutant genes for common industrial Silverblue and Hedlund white coat colours in American mink, Andrey D. Manakhov, Tatiana V. Andreeva, Oleg V. Trapezov, Nikolay A. Kolchanov, and Evgeny I. Rogaev

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Postnatal Zika virus infection of nonhuman primate infants born to mothers infected with homologous Brazilian Zika virus, Nicholas J. Maness and Diogo Magnani

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An order-to-disorder structural switch activates the FoxM1 transcription factor, Aimee H. Marceau, Caileen M. Brison, Santrupti Nerli, Heather E. Arsenault, Andrew C. McShan, Eefei Chen, Hsiau-Wei Lee, Jennifer A. Benanti, Nikolaos G. Sgourakis, and Seth M. Rubin

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Gait Speed and Mood, Cognition, and Quality of Life in Older Adults With Atrial Fibrillation, Francesca Marino, Darleen M. Lessard, Jane S. Saczynski, David D. McManus, Luke G. Silverman-Lloyd, Christopher M. Benson, Michael J. Blaha, and Molly E. Waring

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mTORC2/Akt activation in adipocytes is required for adipose tissue inflammation in tuberculosis, Nuria Martinez, Catherine Y. Cheng, Natkunam Ketheesan, Aidan Cullen, Yuefeng Tang, Josephine Lum, Kim West, Michael Poidinger, David A. Guertin, Amit Singhal, and Hardy Kornfeld

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The Aminoalkylindole BML-190 Negatively Regulates Chitosan Synthesis via the Cyclic AMP/Protein Kinase A1 Pathway in Cryptococcus neoformans, Brian T. Maybruck, Woei C. Lam, Charles A. Specht, Xenia G. Ilagan, Maureen J. Donlin, and Jennifer K. Lodge

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Natural Health Product-Drug Interaction Causality Assessment in Pediatric Adverse Event Reports Associated with Attention-Deficit/Hyperactivity Disorder Medication, Hajra Mazhar, Brian C. Foster, Candace Necyk, Paula M. Gardiner, Cory S. Harris, and Philippe Robaey

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Video-Based Communication Assessment: Development of an Innovative System for Assessing Clinician-Patient Communication, Kathleen M. Mazor, Ann M. King, Ruth B. Hoppe, Annie O. Kochersberger, Jie Yan, and Jesse D. Reim

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Circulating microRNAs miR-331 and miR-195 differentiate local luminal a from metastatic breast cancer, Peter McAnena, Kahraman Tanriverdi, Catherine Curran, K. Gilligan, Jane E. Freedman, James A. L. Brown, and Michael J. Kerin

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Viral Infection or IFN-alpha Alters Mitotic Spindle Orientation by Modulating Pericentrin Levels, William M. McDougall, Jill Perreira, Hui-Fang Hung, Anastassiia Vertii, E. Xiaofei, Wendy Zimmerman, Timothy F. Kowalik, Stephen J. Doxsey, and Abraham L. Brass

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Memory CD4 T cell-derived IL-2 synergizes with viral infection to exacerbate lung inflammation, K. Kai McKinstry, Fahmida Alam, Valeria Flores-Malavet, Mate Z. Nagy, Stewart Sell, Andrea M. Cooper, Susan L. Swain, and Tara M. Strutt

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Geriatric Conditions and Prescription of Vitamin K Antagonists vs. Direct Oral Anticoagulants Among Older Patients With Atrial Fibrillation: SAGE-AF, David D. McManus, Catarina I. Kiefe, Darleen M. Lessard, Francesca Marino, Robert J. Goldberg, Jerry H. Gurwitz, Weijia Wang, and Bruce A. Barton

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Design and Preliminary Findings From a New Electronic Cohort Embedded in the Framingham Heart Study, David D. McManus, Ludovic Trinquart, Emelia J. Benjamin, Emily S. Manders, Kelsey Fusco, Lindsey S. Jung, Nicole L. Spartano, Vik Kheterpal, Christopher Nowak, Mayank Sardana, and Joanne M. Murabito

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Utilization of the validated Psoriasis Epidemiology Screening Tool to identify signs and symptoms of psoriatic arthritis among those with psoriasis: a cross-sectional analysis from the US-based Corrona Psoriasis Registry, P. J. Mease, J. B. Palmer, P. Hur, B. E. Strober, M. Lebwohl, C. Karki, G. W. Reed, C. J. Etzel, J. D. Greenberg, and P. S. Helliwell

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VEGF/Neuropilin Signaling in Cancer Stem Cells, Arthur M. Mercurio

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Genome editing of HBG1 and HBG2 to induce fetal hemoglobin, Jean-Yves Metais, Kevin Luk, Scot A. Wolfe, Shengdar Q. Tsai, and Mitchell J. Weiss

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Diverse repertoire of human adipocyte subtypes develops from transcriptionally distinct mesenchymal progenitor cells, So Yun Min, Anand Desai, Zinger Yang, Agastya Sharma, Tiffany DeSouza, Ryan Genga, Alper Kucukural, Lawrence M. Lifshitz, Soren Nielsen, Camilla Scheele, Rene Maehr, Manuel Garber, and Silvia Corvera

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Exercise Rescues Gene Pathways Involved in Vascular Expansion and Promotes Functional Angiogenesis in Subcutaneous White Adipose Tissue, So Yun Min, Heather Learnard, Shashi Kant, Olga Gaelikman, Raziel Rojas-Rodriguez, Tiffany DeSouza, Anand Desai, John F. Keaney Jr., Silvia Corvera, and Siobhan M. Craige

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Management of recurrent prostate cancer after radiotherapy: long-term results from CALGB 9687 (Alliance), a prospective multi-institutional salvage prostatectomy series, James L. Mohler, Susan Halabi, Stephen T. Ryan, Ali Al-Daghmin, Mitchell H. Sokoloff, Gary D. Steinberg, Ben L. Sanford, James A. Eastham, Philip J. Walther, Michael J. Morris, and Eric J. Small

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The PRogram In Support of Moms (PRISM): study protocol for a cluster randomized controlled trial of two active interventions addressing perinatal depression in obstetric settings, Tiffany A. Moore Simas, Linda Brenckle, Padma Sankaran, Grace A. Masters, Sharina D. Person, Linda Weinreb, Jean Y. Ko, Cheryl L. Robbins, Jeroan J. Allison, and Nancy Byatt

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A critical role of VMP1 in lipoprotein secretion, Hideaki Morishita, Yan G. Zhao, Norito Tamura, Taki Nishimura, Yuki Kanda, Yuriko Sakamaki, Mitsuyo Okazaki, Dongfang Li, and Noboru Mizushima

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Drug Screening for Discovery of Broad-spectrum Agents for Soil-transmitted Nematodes, Elfawal A. Mostafa, Sergey N. Savinov, and Raffi V. Aroian

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Use of Antidiabetic drugs during pregnancy among U.S. women with Livebirth deliveries in the Mini-Sentinel system, Katrina Mott, Marsha E. Reichman, Sengwee Toh, Caren Kieswetter, Katherine Haffenreffer, and Susan E. Andrade

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Pre-clinical medical student reflections on implicit bias: Implications for learning and teaching, Christine Motzkus, Racquel J. Wells, Xingyue Wang, Sonia N. Chimienti, Deborah L. Plummer, Janice Sabin, Jeroan J. Allison, and Suzanne B. Cashman

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Sensitive detection of EBV microRNAs across cancer spectrum reveals association with decreased survival in adult acute myelocytic leukemia, Mercedeh J. Movassagh, Cliff Oduor, Catherine Forconi, Ann M. Moormann, and Jeffrey A. Bailey

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Heart rate, mortality, and the relation with clinical and subclinical cardiovascular diseases: results from the Gutenberg Health Study, Thomas Munzel, Omar Hahad, Tommaso Gori, Sebastian Hollmann, Natalie Arnold, Jurgen H. Prochaska, Andreas Schulz, Manfred Beutel, Norbert Pfeiffer, Irene Schmidtmann, Karl J. Lackner, John F. Keaney Jr., and Philipp S. Wild

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Improving the Health Benefits of Snap Bean: Genome-Wide Association Studies of Total Phenolic Content, James R. Myers, Lyle T. Wallace, Samira Mafi Moghaddam, Adrienne E. Kleintop, Dimas Echeverria, Henry J. Thompson, Mark A. Brick, Rian Lee, and Phillip E. McClean

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Choosing Clinical Variables for Risk Stratification Post-Acute Coronary Syndrome, Paul D. Myers, Wei Huang, Frederick A. Anderson Jr., and Collin M. Stultz

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Thioredoxin Modulates Protein Arginine Deiminase 4 (PAD4)-Catalyzed Citrullination, Mitesh Nagar, Ronak Tilvawala, and Paul R. Thompson

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Necroptosis in anti-viral inflammation, Himani Nailwal and Francis Ka-Ming Chan

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MicroRNA-138 is a Prognostic Biomarker for Triple-Negative Breast Cancer and Promotes Tumorigenesis via TUSC2 repression, Srikanth Nama, Manish Muhuri, Federica Di Pascale, Shan Quah, Luay Aswad, Melissa Fullwood, and Prabha Sampath

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Age-Based Dynamics of a Stable Circulating Cd8 T Cell Repertoire Component, Elena N. Naumova, Maryam B. Yassai, Wendy Demos, Erica Reed, Melissa Unruh, Dipica Haribhai, Calvin B. Williams, Yuri N. Naumov, and Jack Gorski

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Trans-splicing of the C. elegans let-7 primary transcript developmentally regulates let-7 microRNA biogenesis and let-7 family microRNA activity, Charles Nelson and Victor R. Ambros

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An Observational Study With the Janssen Autism Knowledge Engine (JAKE((R))) in Individuals With Autism Spectrum Disorder, Seth L. Ness and Jean A. Frazier

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Use of fenestrated-branched endovascular aneurysm repair to treat Carrel patch aneurysmal degeneration after open thoracoabdominal aortic aneurysm repair, Tammy T. Nguyen, Jessica P. Simons, and Andres Schanzer

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Improvement in mental health following total hip arthroplasty: the role of pain and function, Uyen-Sa D. T. Nguyen, Thomas Perneger, Patricia D. Franklin, Christophe Barea, Pierre Hoffmeyer, and Anne Lubbeke

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Smoke-free environment policy in Vietnam: what did people see and how did they react when they visited various public places, Vinh H. Nguyen, D. A. DO, T. T.H. DO, T. M.A. Dao, B. G. Kim, T H. Phan, T. H. Doan, N. K. Luong, T. L. Nguyen, V. M. Hoang, T. Q. N. Pham, and T. Q. Nguyen

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Redirection of SKN-1 abates the negative metabolic outcomes of a perceived pathogen infection, James D. Nhan, Christian D. Turner, Sarah M. Anderson, Chia-An Yen, Hans M. Dalton, Hilary K. Cheesman, Dana L. Ruter, Nandhitha Uma Naresh, Cole M. Haynes, Alexander A. Soukas, Read Pukkila-Worley, and Sean P. Curran

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Oncogenic Pathways and Loss of the Rab11 GTPase Synergize To Alter Metabolism in Drosophila, Yingchao Nie, Shiyan Yu, Qi Li, Niraj K. Nirala, Alla Amcheslavsky, Yvonne J. K. Edwards, Patrick W. Shum, Zhong Jiang, Wei Wang, Biliang Zhang, Nan Gao, and Y. Tony Ip

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The NuA4 acetyltransferase and histone H4 acetylation promote replication recovery after topoisomerase I-poisoning, Chiaki Noguchi, Tanu Singh, Melissa A. Ziegler, Jasmine D. Peake, Lyne Khair, Ana Aza, Toru M. Nakamura, and Eishi Noguchi

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General population normative data for the EORTC QLQ-C30 health-related quality of life questionnaire based on 15,386 persons across 13 European countries, Canada and the Unites States, S. Nolte, G. Liegl, M. A. Petersen, N. K. Aaronson, A. Costantini, P. M. Fayers, M. Groenvold, B. Holzner, C. D. Johnson, G Kemmler, K. A. Tomaszewski, A. Waldmann, T. E. Young, and Matthias S. F. Rose

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A highly expressed intestinal cysteine protease of Ancylostoma ceylanicum protects vaccinated hamsters from hookworm infection, Jason B. Noon, Erich M. Schwarz, Gary R. Ostroff, and Raffi V. Aroian

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U.S. prevalence of endocrine therapy-naive locally advanced or metastatic breast cancer, Anthony P. Nunes, C. Liang, W. J. Gradishar, T. Dalvi, J. Lewis, N. Jones, E. Green, M. Doherty, and J. D. Seeger

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Differential skewing of donor-unrestricted and gammadelta T cell repertoires in tuberculosis-infected human lungs, Paul Ogongo, Adrie Jc. Steyn, Farina Karim, Kaylesh J. Dullabh, Ismael Awala, Rajhmun Madansein, Alasdair Leslie, and Samuel M. Behar

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Orthopaedic Faculty and Resident Sex Diversity Are Associated with the Orthopaedic Residency Application Rate of Female Medical Students, Kanu Okike, Donna P. Phillips, Eric F. Swart, and Mary I. O'Connor

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Shortened cataract surgery by standardisation of the perioperative protocol according to the Joint Commission International accreditation: a retrospective observational study, Yuichi Okumura, Takenori Inomata, Masao Iwagami, Atsuko Eguchi, Ju Mizuno, Tina Shiang, Shiori Kawasaki, Akie Shimada, Eiichi Inada, Atsushi Amano, and Akira Murakami

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Extracellular-Signal Regulated Kinase: A Central Molecule Driving Epithelial-Mesenchymal Transition in Cancer, Monserrat Olea-Flores, Miriam Daniela Zuniga-Eulogio, Miguel Angel Mendoza-Catalan, Hugo Alberto Rodriguez-Ruiz, Eduardo Castaneda-Saucedo, Carlos Ortuno-Pineda, Teresita Padilla-Benavides, and Napoleon Navarro-Tito

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Leptin Promotes Expression of EMT-Related Transcription Factors and Invasion in a Src and FAK-Dependent Pathway in MCF10A Mammary Epithelial Cells, Monserrat Olea-Flores, Miriam Zuniga-Eulogio, Arvey Tacuba-Saavedra, Magdalena Bueno-Salgado, Andrea Sanchez-Carvajal, Yovani Vargas-Santiago, Miguel A. Mendoza-Catalan, Eduardo Perez Salazar, Alejandra Garcia-Hernandez, Teresita Padilla-Benavides, and Napoleon Navarro-Tito

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Integrins Have Cell-Type-Specific Roles in the Development of Motor Neuron Connectivity, Devyn Oliver, Emily Norman, Heather Bates, Rachel Avard, Monika Rettler, Claire Y. Benard, Michael M. Francis, and Michele L. Lemons

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Chronic Pain Practices: An Evaluation of Positive and Negative Online Patient Reviews, Mariam Salisu Orhurhu, Bisola Salisu, Emily Sottosanti, Niyi Abimbola, Ivan Urits, Mark Jones, Omar Viswanath, Alan D. Kaye, Thomas Simopoulos, and Vwaire Orhurhu

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Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways, Maire F. Osborn, Andrew H. Coles, Annabelle Biscans, Reka A. Haraszti, Loic Roux, Sarah M. Davis, Socheata Ly, Dimas Echeverria, Matthew R. Hassler, Bruno M. D. C. Godinho, Mehran Nikan, and Anastasia Khvorova

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Inclusion Body Myositis, Sreelakshmi Panginikkod and Rina Musa

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Uhthoff Phenomenon, Sreelakshmi Panginikkod and Lokesh A.. Rukmangadachar

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Cognitive and Microbiome Impacts of Experimental Ancylostoma ceylanicum Hookworm Infections in Hamsters, Samuel C. Pan, Doyle V. Ward, Yunqiang Yin, Yan Hu, Elfawal A. Mostafa, Robert E. Clark, and Raffi V. Aroian

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Therapy with Biologic Agents After Diagnosis of Solid Malignancies: Results from the Corrona Registry, Dimitrios A. Pappas, Sabrina Rebello, Mei Liu, Jennifer Schenfeld, Youfu Li, David H. Collier, and Neil A. Accortt

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Sptlc1 is essential for myeloid differentiation and hematopoietic homeostasis, Velayoudame Parthibane, Usha Acharya, and Jairaj K. Acharya

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"Found Down" Compartment Syndrome: Experience from the Front Lines of the Opioid Epidemic, Lydia Parzych, Jacob Jo, Amna Diwan, and Eric F. Swart

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F-box protein FBXO16 functions as a tumor suppressor by attenuating nuclear beta-catenin function, Debasish Paul, Sehbanul Islam, Rajesh Kumar. Manne, U. S. Dinesh, Sunil K. Malonia, Biswanath Maity, Ramanamurthy Boppana, Srikanth Rapole, Praveen Kumar Shetty, and Manas Kumar Santra

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Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex, Lovely Jael Paul Solomon Devakumar, Christl Gaubitz, Victoria Lundblad, Brian A. Kelch, and Takashi Kubota

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Plasma Eicosanoid Levels in Tuberculosis and Tuberculosis-Diabetes Co-morbidity Are Associated With Lung Pathology and Bacterial Burden, Nathella Pavan Kumar, Kadar Moideen, Arul Nancy, Vijay Viswanathan, Basavaradhya S. Shruthi, Sivakumar Shanmugam, Syed Hissar, Hardy Kornfeld, and Subash Babu

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Enhanced Cas12a editing in mammalian cells and zebrafish, Pengpeng Liu, Kevin Luk, Masahiro Shin, Feston Idrizi, Samantha F. Kwok, Benjamin P. Roscoe, Esther Mintzer, Sneha Suresh, Kyle Morrison, Josias B. Frazao, Mehmet Fatih Bolukbasi, Karthikeyan Ponnienselvan, Jeremy Luban, Lihua Julie Zhu, Nathan D. Lawson, and Scot A. Wolfe

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Unfolded states under folding conditions accommodate sequence-specific conformational preferences with random coil-like dimensions, Ivan Peran, Alex S. Holehouse, Isaac S. Carrico, Rohit V. Pappu, Osman Bilsel, and Daniel P. Raleigh

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The nuclear hormone receptor NHR-86 controls anti-pathogen responses in C. elegans, Nicholas D. Peterson, Hilary K. Cheesman, Pengpeng Liu, Sarah M. Anderson, Kyle J. Foster, Richa Chhaya, Paola N. Perrat, Jose Thekkiniath, Qiyuan Yang, Cole M. Haynes, and Read Pukkila-Worley

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Pax9 is required for cardiovascular development and interacts with Tbx1 in the pharyngeal endoderm to control 4(th) pharyngeal arch artery morphogenesis, Helen M. Phillips, Rene Maehr, and Simon D. Bamforth

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A global analysis of IFT-A function reveals specialization for transport of membrane-associated proteins into cilia, Tyler Picariello, Jason M. Brown, Yuqing Hou, Gregory Swank, Deborah A. Cochran, Oliver D. King, Karl Lechtreck, Gregory J. Pazour, and George B. Witman

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Insulin Receptor Substrate-1 (IRS-1) and IRS-2 expression levels are associated with prognosis in non-small cell lung cancer (NSCLC), Andrew J. Piper, Jennifer L. Clark, Jose R. Mercado-Matos, Asia N. Matthew-Onabanjo, Chung-Cheng Hsieh, Ali Akalin, and Leslie M. Shaw

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Introduction to the special issue on reproducibility in neuroimaging, Russell A. Poldrack, Kirstie Whitaker, and David N. Kennedy

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CXCR3 chemokine receptor guides Trypanosoma cruzi-specific T-cells triggered by DNA/adenovirus ASP2 vaccine to heart tissue after challenge, Camila Pontes Ferreira, Leonardo Moro Cariste, Barbara Ferri Moraschi, Bianca Ferrarini Zanetti, Sang Won Han, Daniel Araki Ribeiro, Alexandre Vieira Machado, Joseli Lannes-Vieira, Ricardo T. Gazzinelli, and Jose Ronnie Vasconcelos Carvalho

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Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia, Gayle P. Pouliot, Justine E. Roderick, and Alejandro Gutierrez

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The structure of the endogenous ESX-3 secretion system, Nicole Poweleit, Nadine Czudnochowski, Rachel Nakagawa, Donovan Trinidad, Kenan C. Murphy, Christopher M. Sassetti, and Oren S. Rosenberg

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Long-Term Therapeutic Efficacy of Intravenous AAV-Mediated Hamartin Replacement in Mouse Model of Tuberous Sclerosis Type 1, Shilpa Prabhakar, Pike See Cheah, Xuan Zhang, Max Zinter, Maria Gianatasio, Eloise Hudry, Roderick T. Bronson, David J. Kwiatkowski, Anat Stemmer-Rachamimov, Casey A. Maguire, Miguel Sena-Esteves, Bakhos A. Tannous, and Xandra O. Breakefield